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Archives of Gynecology and Obstetrics
Erschienen in: Archives of Gynecology and Obstetrics 3/2019

04.01.2019 | Review

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

verfasst von: Xiaqin Huo, Liang Yao, Xue Han, Wen Li, Junjuan Liu, Lijun Zhou, Yuanfeng Gou, Kehu Yang, Huiling Liu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2019

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Abstract

Purpose

The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.

Methods

PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).

Results

A total of 18 case–control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83–1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I2 = 0%), and no statistical significance for serous and mucinous.

Conclusions

Hysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.
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Metadaten
Titel
Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis
verfasst von
Xiaqin Huo
Liang Yao
Xue Han
Wen Li
Junjuan Liu
Lijun Zhou
Yuanfeng Gou
Kehu Yang
Huiling Liu
Publikationsdatum
04.01.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 3/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-018-5020-1

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