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Breast Cancer Research

Erschienen in:

01.06.2005 | Poster Presentation

Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray

verfasst von: NAS Rao, R van den Ham, M van Wolferen, JA Mol

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

Tumors of the mammary gland belong to the most common tumors in the female dog. Ovarian hormones and signaling cascades involving them play an important role in mammary tumor formation and progression in the female dog, as early ovariectomy may reduce the incidence of mammary carcinoma from 30% to less than 2%. The phenotypic expression of canine mammary tumors may vary, even within one affected animal. In the past, growth factor-independent canine mammary cell lines have been isolated [1]. Molecular characterization of these cell lines and correlation of their molecular signatures to biological behavior may lead to better understanding of signaling pathways involved in mammary cancer and classification of spontaneous mammary tumors. …

Hellmen E, Moller M, Blankenstein MA, Andersson L, Westermark B: Expression of different phenotypes in cell lines from canine mammary spindle-cell tumors and osteosarcomas indicating a pluripotent mammary stem cell origin. Breast Cancer Res Treat. 2000, 61: 197-210. 10.1023/A:1006410020384.CrossRefPubMed

Roepman P, Wessels LF, Kettelarij N, Kemmeren P, Miles AJ, Lijn-zaad P, Tilanus MG, Koole R, Hordijk GJ, van der Vliet PC, et al: An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet. 2005, 37: 182-186. 10.1038/ng1502.CrossRefPubMed

Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001, 98: 5116-5121. 10.1073/pnas.091062498.CrossRefPubMedPubMedCentral

Titel: Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray
verfasst von: NAS Rao
R van den Ham
M van Wolferen
JA Mol
Publikationsdatum: 01.06.2005
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1165

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25.04.2024 | Nierenkarzinom | Nachrichten

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Identification of differentially expressed genes in canine mammary tumor cell lines using a newly developed canine-specific cDNA microarray

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