Erschienen in:
01.02.2004 | Meeting abstract
IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
verfasst von:
MI Koenders, E Lubberts, LAB Joosten, JK Kolls, WB van den Berg
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2004
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Excerpt
In the murine macrophage-mediated SCW-induced arthritis, IL-1 plays a dominant role in cartilage destruction, as was shown in previous studies using cytokine gene knockout mice or antibodies against IL-1. T cell IL-17 is a proinflammatory cytokine that has many IL-1-like activities. IL-17 is expressed in the synovium of RA patients and may play a role in rheumatoid arthritis (RA) pathology. …