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01.11.2011 | Review

Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma

verfasst von: Adam J. Bograd, Kei Suzuki, Eva Vertes, Christos Colovos, Eduardo A. Morales, Michel Sadelain, Prasad S. Adusumilli

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2011

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Abstract

Malignant pleural mesothelioma (MPM) is an aggressive, primary pleural malignancy with poor prognosis, hypothesized to originate from a chronic inflammatory state within the pleura. Similar to what has been observed in other solid tumors (melanoma, ovarian and colorectal cancer), clinical and pre-clinical MPM investigations have correlated anti-tumor immune responses with improved survival. As such, a better understanding of the complex MPM tumor microenvironment is imperative in strategizing successful immunotherapies. Herein, we review the immune responses vital to the development and progression of MPM, as well as assess the role of immunomodulatory therapies, highlighting recent pre-clinical and clinical immunotherapy investigations.

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Titel: Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma
verfasst von: Adam J. Bograd
Kei Suzuki
Eva Vertes
Christos Colovos
Eduardo A. Morales
Michel Sadelain
Prasad S. Adusumilli
Publikationsdatum: 01.11.2011
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 11/2011
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-011-1103-6

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma

Abstract

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Springer Medizin

Abstract

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