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Clinical Oral Investigations

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01.03.2014 | Original Article

Immunohistochemical analysis of staged guided bone regeneration and osseointegration of titanium implants using a polyethylene glycol membrane

verfasst von: Ilja Mihatovic, Vladimir Golubovic, Jürgen Becker, Frank Schwarz

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2014

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Abstract

Objectives

This study aimed to immunohistochemically evaluate staged guided bone regeneration and osseointegration of titanium implants using two bone graft substitutes in combination with a polyethylene glycol (PEG) membrane in a dog model.

Materials and methods

Saddle-type alveolar ridge defects were prepared in the lower jaws of 12 foxhounds and randomly filled with a natural bone mineral (NBM) or a biphasic calcium phosphate (SBC) and covered with an in situ gelling PEG membrane. After a healing period of 8 and 12 weeks (six animals each), modSLA titanium implants were inserted to heal in a submerged position. At 8 + 2 and 12 + 2 weeks, respectively, dissected blocks were processed for immunohistochemical analysis [osteocalcin (OC)].

Results

After 8 + 2 weeks, mean OC values (%) tended to be higher in the NBM group (NBM, 32.7 ± 8.9 %), but failed to reach statistical significance over the SBC group (SBC, 24.4 ± 6.6 %). After 12 + 2 weeks, mean OC values decreased in both groups and was almost identical in both groups (NBM 1.6 ± 1.2 %/SBC 2.1 ± 1.4 %).

Conclusion

It was concluded that all augmentation procedures investigated were characterised by a comparable OC activity during the process of bone regeneration and osseointegration of modSLA titanium implants.

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Titel: Immunohistochemical analysis of staged guided bone regeneration and osseointegration of titanium implants using a polyethylene glycol membrane
verfasst von: Ilja Mihatovic
Vladimir Golubovic
Jürgen Becker
Frank Schwarz
Publikationsdatum: 01.03.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 2/2014
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-013-0995-2

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Immunohistochemical analysis of staged guided bone regeneration and osseointegration of titanium implants using a polyethylene glycol membrane

Abstract

Objectives

Materials and methods

Results

Conclusion

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Springer Medizin

Abstract

Objectives

Materials and methods

Results

Conclusion

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