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Erschienen in:
01.07.2014 | Original Article
Immunohistochemical characteristics of regenerated bone after surgical therapy of advanced ligature-induced peri-implantitis defects
Erschienen in: Clinical Oral Investigations | Ausgabe 6/2014
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Objectives
This study seeks to assess and compare immunohistochemical characteristics of regenerated and pristine bone areas following surgical therapy of advanced peri-implantitis.
Methods
At ligature-induced peri-implantitis defects, the intrabony component was filled with a natural bone mineral (NBM), and the supracrestal component was treated by either an equine bone block (EB) or implantoplasty. NBM and EB were soak-loaded with rhBMP-2 or sterile saline. Membrane (i.e., native collagen) protected sites were submerged for 12 weeks. Osteocalcin (OC) and transglutaminase 2 (TG2; angiogenesis) antigen reactivity was assessed within the augmented- (AA) and pristine bone (PB) areas at non-exposed sites (n = 39 defects).
Results
In all groups investigated, mean OC (AA, 0.5 ± 0.4 to 1.9 ± 2.9 %/PB, 1.7 ± 2.6 to 3.5 ± 6.5 %) and TG2 (AA, 0.6 ± 0.5 to 1.3 ± 1.5 %/PB, 0.5 ± 0.5 to 1.6 ± 1.9 %) values within AA did not significantly differ from those values assessed within PB (P > 0.05, respectively).
Conclusions
AA formed in different treatment groups may not be considered as qualitatively (i.e., OC and TG2) compromised bone.