Introduction
Cytokine gens | SNP analyzed | Associated with periodontitis –/+ | Year | Country | Publication |
---|---|---|---|---|---|
IL-1α
|
– 889
|
–
|
2013
|
Macedonia
| [24] |
– 889, + 4854
|
–
|
2015
|
India
| [25] | |
– 889
|
–
|
2015
|
Algeria
| [31] | |
– 889
|
+
|
2000
|
England
| [169] | |
– 889
|
–
|
2003
|
Thailand
| [39] | |
+ 4845
|
–
|
1999
|
America
| [37] | |
+ 4845
|
–
|
2007
|
Japan
| [38] | |
– 889, + 4845
|
+
|
2012
|
America
| [27] | |
– 889
|
+
|
2013
|
China
| [28] | |
– 889
|
+
|
2016
|
China
| [29] | |
– 889
|
+
|
1997
|
America
| [170] | |
– 889
|
+
|
2007
|
Brazil
| [41] | |
– 889
|
+
|
2001
|
Netherlands
| [42] | |
– 889
|
+
|
2007
|
Germany
| [43] | |
– 889
|
–
|
2005
|
America
| [47] | |
– 889
|
–
|
1998
|
America
| [50] | |
– 889
|
–
|
2002
|
Australia
| [51] | |
– 889
|
+
|
2008
|
Germany
| [52] | |
+ 4854
|
–
|
2008
|
Denmark
| [57] | |
– 889
|
+
|
2005
|
England
| [58] | |
+ 4845
|
–
|
2000
|
China
| [61] | |
+ 4845
|
+
|
2000
|
America
| [62] | |
+ 4845
|
+
|
2005
|
India
| [63] | |
+ 4845
|
+
|
2000
|
America
| [65] | |
– 889
|
–
|
2007
|
Finland
| [75] | |
+ 4845
– 889
|
–
+
|
2008
|
Greece
| [81] | |
+ 4845
|
–
|
2006
|
Greece
| [121] | |
+ 4845
|
–
|
2009
|
Japan
| [130] | |
– 889
|
+
|
2012
|
China
| [148] | |
IL-1β
|
– 511
+ 3962
|
+
–
|
2013
|
Macedonia
| [24] |
– 511
+ 3954
|
-
+
|
2015
|
India
| [25] | |
– 511
|
–
|
2015
|
China
| [30] | |
– 511
+ 3954
|
–
+
|
1997
|
America
| [170] | |
+ 3954
|
+
|
2015
|
Algeria
| [31] | |
+ 3954
|
+
|
2007
|
Japan
| [38] | |
+ 3954
|
–
|
2003
|
Thailand
| [39] | |
+ 3954
|
+
|
1999
|
America
| [37] | |
+ 3954
|
+
|
2012
|
America
| [27] | |
+ 3954
|
+
|
2016
|
China
| [29] | |
+ 3954
|
+
|
2001
|
Netherlands
| [42] | |
+3954
|
+
|
2007
|
Germany
| [43] | |
–511, – 1464, – 3737, + 3877
|
+
|
2015
|
America
| [44] | |
+ 3954
|
+
|
2015
|
China
| [45] | |
+3954
|
+
|
2005
|
America
| [47] | |
+3954
|
+
|
2005
|
Brazil
| [48] | |
+3954
– 511
|
+
–
|
1998
|
America
| [50] | |
+3954
|
+
|
2002
|
Australia
| [51] | |
+3954
|
+
|
2008
|
Germany
| [52] | |
+3954
|
–
|
2016
|
Colombia
| [53] | |
+3954
|
–
|
2015
|
Brazil
| [54] | |
+3954, − 511
− 31
|
+
–
|
2015
|
India
| [55] | |
+ 3954
|
+
|
2012
|
India
| [56] | |
+3954, – 511
|
+
|
2008
|
Denmark
| [57] | |
– 511, + 3954
|
–
|
2005
|
England
| [58] | |
+3954
|
–
|
2000
|
China
| [61] | |
+3954
|
+
|
2000
|
America
| [62] | |
+3954
|
+
|
2005
|
India
| [63] | |
+3954
|
+
|
2000
|
America
| [65] | |
+3954
|
–
|
2007
|
Finland
| [75] | |
+3954
– 511
|
+
–
|
2008
|
Greece
| [81] | |
+3954
|
–
|
2006
|
Greece
| [121] | |
+3954
–31
|
+
–
|
2009
|
Japan
| [130] | |
IL1RN
|
IL1R pstl1970, IL1RN mspa111100
|
–
|
2013
|
Macedonia
| [24] |
IL1RN VNTR
|
–
|
2015
|
India
| [25] | |
IL1RN + 2018
|
–
|
2007
|
Japan
| [38] | |
IL1RN VNTR
|
+
|
2001
|
Netherlands
| [42] | |
IL1RN VNTR
|
–
|
2008
|
Denmark
| [57] | |
IL1RN VNTR
|
+
|
2012
|
China
| [59] | |
IL1RN VNTR
|
+
|
2006
|
Turkey
| [60] | |
+ 2018
|
–
|
2009
|
Japan
| [130] | |
IL-6
|
–174
|
+
|
2005
|
England
| [58] |
–174
|
–
|
2010
|
Turkey
| [68] | |
–174
|
+
|
2007
|
Brazil
| [41] | |
–174
|
+
|
2003
|
Brazil
| [72] | |
–174
|
+
|
2014
|
Brazil
| [73] | |
–174
|
+
|
2006
|
Germany
| [74] | |
–174
|
+
|
2007
|
Finland
| [75] | |
–373
–597, –572, –190, – 174
|
+
–
|
2005
|
Japan
| [76] | |
– 174
|
–
|
2009
|
England
| [78] | |
– 572
– 597, – 174
|
+
–
|
2004
|
Czech
| [79] | |
–1363
– 572
|
+
–
|
2014
|
China
| [80] | |
–174
|
–
|
2008
|
Greece
| [81] | |
–572, – 174
|
–
|
2009
|
Japan
| [130] | |
–174
+ 874
|
+
–
|
2006
|
Germany
| [74] | |
IL-10
|
– 627, – 1082
|
–
|
2005
|
England
| [58] |
– 1082, – 819, – 592
|
–
|
2010
|
Turkey
| [68] | |
– 1082
|
–
|
2006
|
Germany
| [74] | |
– 1082
|
–
|
2007
|
Finland
| [75] | |
– 1082
|
+
|
2003
|
Sweden
| [90] | |
– 819, – 592
– 1087
|
+
–
|
2004
|
Brazil
| [91] | |
– 592
– 819
|
+
–
|
2007
|
Turkey
| [92] | |
– 1082
– 819, – 592
|
+
–
|
2012
|
Macedonia
| [93] | |
– 819, – 592
– 1082
|
+
–
|
2012
|
China
| [94] | |
– 819, – 592
– 1082
|
+
–
|
2012
|
Portugal
| [171] | |
– 1082
|
+
|
2015
|
India
| [96] | |
– 1082, – 592
|
+
|
2012
|
Germany
| [97] | |
– 1082
|
–
|
2015
|
Brazil
| [98] | |
– 1082
|
–
|
2014
|
Brazil
| [99] | |
– 592
|
+
|
2008
|
Brazil
| [102] | |
– 1082, – 819, – 592
|
–
|
2008
|
Germany
| [145] | |
– 1082, – 819, – 592
|
–
|
2001
|
Japan
| [106] | |
– 1082
|
–
|
2006
|
Germany
| [74] | |
– 1082, – 819
|
–
|
2009
|
Japan
| [130] | |
TGF-β
|
– 509, – 788
|
–
|
2013
|
Iran
| [10] |
– 29
|
+
|
2013
|
Iran
| [10] | |
Codons 10 and 25
|
–
|
2010
|
Turkey
| [68] | |
Codon 10
Codon 25
|
–
+
|
2006
|
Germany
| [74] | |
– 988, – 800, – 509, Codons 10 and 25
|
–
|
2002
|
Czech
| [129] | |
– 509, + 869, + 915
|
–
|
2009
|
Japan
| [130] | |
+ 915
Thr263Ile and 713/8delC
|
+
–
|
2006
|
Turkey
| [131] | |
− 509
|
+
|
2009
|
China
| [133] | |
Codons 10 and 25
|
+
|
2009
|
Macedonia
| [134] | |
Codon 25
Codon 10
|
+
–
|
2006
|
Germany
| [74] | |
IFN-γ
|
+ 874
|
+
|
2015
|
Iran
| [8] |
+ 874
|
–
|
2010
|
Turkey
| [68] | |
+874
|
–
|
2006
|
Germany
| [74] | |
+874
|
+
|
2008
|
Germany
| [145] | |
– 5644
|
–
|
2008
|
Iran
| [146] | |
+874
|
–
|
2011
|
Czech
| [147] | |
IFN-γR1
|
– 611, + 189, + 95
|
–
|
2015
|
Iran
| [8] |
TNF-α
|
– 308
|
–
|
1997
|
America
| [170] |
– 1031, – 863, – 857
|
+
|
2003
|
Japan
| [46] | |
– 308
|
+
|
1999
|
America
| [48] | |
– 308
|
–
|
2005
|
England
| [58] | |
– 308
|
+
|
2010
|
Turkey
| [68] | |
– 308
|
–
|
2006
|
Germany
| [74] | |
– 308
|
–
|
2007
|
Finland
| [75] | |
– 308
|
–
|
2008
|
Greece
| [81] | |
– 308
|
–
|
2014
|
Iran
| [108] | |
– 308
|
–
|
2003
|
Czech
| [111] | |
– 1031
– 857, – 308, – 238
|
+
–
|
2013
|
China
| [114] | |
– 308, – 863
– 238
|
+
–
|
2014
|
China
| [115] | |
– 308
|
+
|
2015
|
Turkey
| [116] | |
– 308, – 238
|
+
|
2008
|
Germany
| [117] | |
– 308
|
–
|
2005
|
Sweden
| [118] | |
– 308
|
–
|
2004
|
Germany
| [119] | |
– 238, – 308, + 252
|
–
|
1998
|
America
| [120] | |
– 308
|
–
|
2006
|
Greece
| [121] | |
– 863, – 857
|
–
|
2009
|
Japan
| [130] | |
– 308
|
–
|
2006
|
Germany
| [74] | |
Vitamin D Receptor
|
– 1056
|
+
|
2005
|
England
| [58] |
FokI
ApaI, BsmI
|
+
–
|
2007
|
Japan
| [160] | |
TaqI, ApaI, BsmI
|
–
|
2008
|
Turkey
| [161] | |
TaqI, BsmI
|
+
|
2004
|
Brazil
| [162] | |
TaqI
FokI
|
+
–
|
2003
|
Japan
| [163] | |
TaqI
|
–
|
2002
|
China
| [164] | |
TaqI
|
+
|
2013
|
India
| [165] | |
ApaI, BsmI
TaqI
|
+
–
|
2013
|
Jordan
| [166] | |
ApaI
BsmI, FokI
|
+
–
|
2015
|
Libya
| [167] |