nach oben

European Journal of Medical Research

Erschienen in:

01.12.2010 | Research

Impact of gastro-oesophageal reflux disease on work productivity despite therapy with proton pump inhibitors in Germany

verfasst von: M Gross, U Beckenbauer, J Burkowitz, H Walther, B Brueggenjuergen

Erschienen in: European Journal of Medical Research | Ausgabe 3/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

Gastro-oesophageal reflux disease (GERD) is a common disorder with consequences for the patient's health-related quality of life (HRQoL). In Germany, few data are available on the impact of GERD on work-related productivity.

Aim

To study the impact of GERD on work productivity despite proton pump inhibitor (PPI) therapy and the association between productivity and symptom duration, severity, and HRQoL.

Methods

Retrospective data from randomly selected patients with chronic GERD symptoms, treated by office-based general practitioners or general internists with routine clinical care, were analyzed together with information from self-administered instruments assessing work productivity (WPAI-GERD), symptoms (RDQ), and HRQoL (QOLRAD).

Results

Reduced productivity was reported by 152 of 249 patients (61.0%), although 89.5% of them were treated with PPI. The reduction in work productivity was 18.5% in all patients and 30.3% in those with reduced productivity. Patients with impaired productivity showed a significantly lower HRQoL and more-severe symptoms of reflux disease. In all patients, the mean sick leave attributable to reflux symptoms was 0.6 hours in the previous seven days and 1.4 work days in the previous three months.

Conclusion

GERD has a substantial impact on work productivity in Germany, even in patients receiving routine clinical care and PPI therapy.

Dent J, El-Serag HB, Wallander MA, Johansson S: Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005,54(5):710–717. 10.1136/gut.2004.051821PubMedCentralPubMedCrossRef

Willich SN, Nocon M, Kulig M, Jaspersen D, Labenz J, Meyer-Sabellek W, Stolte M, Lind T, Malfertheiner P: Cost-of-disease analysis in patients with gastro-oesophageal reflux disease and Barrett's mucosa. Aliment Pharmacol Ther 2006,23(3):371–376. 10.1111/j.1365-2036.2006.02763.xPubMedCrossRef

Kulig M, Leodolter A, Vieth M, Schulte E, Jaspersen D, Labenz J, Lind T, Meyer-Sabellek W, Malfertheiner P, Stolte M, Willich SN: Quality of life in relation to symptoms in patients with gastro-oesophageal reflux disease--an analysis based on the ProGERD initiative. Aliment Pharmacol Ther 2003,18(8):767–776. 10.1046/j.1365-2036.2003.01770.xPubMedCrossRef

Nocon M, Keil T, Willich SN: Prevalence and sociodemographics of reflux symptoms in Germany--results from a national survey. Aliment Pharmacol Ther 2006,23(11):1601–1605. 10.1111/j.1365-2036.2006.02924.xPubMedCrossRef

Hungin AP, Raghunath AS, Wiklund I: Beyond heartburn: a systematic review of the extra-oesophageal spectrum of reflux-induced disease. Fam Pract 2005,22(6):591–603. 10.1093/fampra/cmi061PubMedCrossRef

Wiklund I: Review of the quality of life and burden of illness in gastroesophageal reflux disease. Dig Dis 2004,22(2):108–114. 10.1159/000080308PubMedCrossRef

Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, Talley NJ, Agreus L: Gastrooesophageal reflux symptoms and health-related quality of life in the adult general population - the Kalixanda study. Aliment Pharmacol Ther 2006,23(12):1725–1733. 10.1111/j.1365-2036.2006.02952.xPubMedCrossRef

Wahlqvist P, Reilly MC, Barkun A: Systematic review: the impact of gastro-oesophageal reflux disease on work productivity. Aliment Pharmacol Ther 2006,24(2):259–272. 10.1111/j.1365-2036.2006.02996.xPubMedCrossRef

Wahlqvist P, Brook RA, Campbell SM, Wallander MA, Alexander AM, Smeeding JE, Kleinman NL: Objective measurement of work absence and on-the-job productivity: a case-control study of US employees with and without gastroesophageal reflux disease. J Occup Environ Med 2008,50(1):25–31. 10.1097/JOM.0b013e31815dba5aPubMedCrossRef

10.

Leodolter A, Nocon M, Kulig M, Willich SN, Malfertheiner P, Labenz J: Gastro esophageal reflux disease is associated with absence from work: Results from a prospective cohort study. World J Gastroenterol 2005,11(45):7148–7151.PubMed

11.

Liker H, Jones R, Ducrotte P: The effect of sleep disturbance due to gastroesophageal reflux diesease on work and leisure productivity: results from a multinational survey. Gastroenterology 2005, 128: A386.

12.

Meining A, Driesnack U, Classen M, Rösch T: Management of gastroesophageal reflux disease in primary care: results of a survey in 2 areas in Germany. Z Gastroenterol 2002,40(1):15–20. 10.1055/s-2002-19638PubMedCrossRef

13.

Wiklund IK, Junghard O, Grace E, Talley NJ, Kamm M, Veldhuyzen van Zanten S, Paré P, Chiba N, Leddin DS, Bigard MA, Colin R, Schoenfeld P: Quality of Life in Reflux and Dyspepsia patients. Psychometric documentation of a new disease-specific questionnaire (QOLRAD). Eur J Surg Suppl 1998, 583: 41–49.PubMed

14.

Crawley J, Frank L, Joshua-Gotlib S, Flynn J, Frank S, Wiklund I: Measuring change in quality of life in response to Helicobacter pylori eradication in peptic ulcer disease: the QOLRAD. Dig Dis Sci 2001,46(3):571–580. 10.1023/A:1005655317121PubMedCrossRef

15.

Kulich KR, Malfertheiner P, Madisch A, Labenz J, Bayerdörffer E, Miehlke S, Carlsson J, Wiklund IK: Psychometric validation of the German translation of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in patients with reflux disease. Health Qual Life Outcomes 2003, 1: 62. 10.1186/1477-7525-1-62PubMedCentralPubMedCrossRef

16.

Shaw MJ, Talley NJ, Beebe TJ, Rockwood T, Carlsson R, Adlis S, Fendrick AM, Jones R, Dent J, Bytzer P: Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 2001,96(1):52–57. 10.1111/j.1572-0241.2001.03451.xPubMedCrossRef

17.

Nocon M, Kulig M, Leodolter A, Malfertheiner P, Willich SN: Validation of the Reflux Disease Questionnaire for a German population. Eur J Gastroenterol Hepatol 2005,17(2):229–233. 10.1097/00042737-200502000-00015PubMedCrossRef

18.

Reilly MC, Zbrozek AS, Dukes EM: The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993,4(5):353–365. 10.2165/00019053-199304050-00006PubMedCrossRef

19.

Wahlqvist P, Carlsson J, Stalhammar NO, Wiklund I: Validity of a Work Productivity and Activity Impairment questionnaire for patients with symptoms of gastroesophageal reflux disease (WPAI-GERD)--results from a cross-sectional study. Value Health 2002,5(2):106–113. 10.1046/j.1524-4733.2002.52101.xPubMedCrossRef

20.

Wahlqvist P: Symptoms of gastroesophageal reflux disease, perceived productivity, and health-related quality of life. Am J Gastroenterol 2001,96(8 Suppl):S57–61.PubMedCrossRef

21.

Calleja JL, Bixquert M, Maldonado J: Impact of nocturnal heartburn on quality of life, sleep, and productivity: the SINERGE study. Dig Dis Sci 2007,52(10):2858–2865. 10.1007/s10620-006-9196-zPubMedCrossRef

22.

Rey E, Elola-Olaso C, Rodríguez Artalejo F, Díaz-Rubio M: Impact of gastroesophageal reflux symptoms on health resource usage and work absenteeism in Spain. Rev Esp Enferm Dig 2006,98(7):518–526.PubMedCrossRef

23.

Stewart WF, Ricci JA, Leotta C: Health-related lost productive time (LPT): recall interval and bias in LPT estimates. J Occup Environ Med 2004,46(6 Suppl):S12–22.PubMedCrossRef

24.

Dean BB, Crawley JA, Schmitt CM, Wong J, Ofman JJ: The burden of illness of gastro-oesophageal reflux disease: impact on work productivity. Aliment Pharmacol Ther 2003,17(10):1309–1317. 10.1046/j.1365-2036.2003.01588.xPubMedCrossRef

25.

Jones R, Armstrog D, Mnalfertheiner P, Ducrotté P: Does the treatment of gastroesophageal reflux disease (GERD) meet patients' needs? A survey-based study. Curr Med Res Opin 2006,22(4):657–662. 10.1185/030079906X100032PubMedCrossRef

26.

Kirby CN, Piterman L, Nelson MR, Dent J: Gastro-oesophageal reflux disease--impact of guidelines on GP management. Aust Fam Physician 2008,37(1–2):73–77.PubMed

27.

Koopmanschap MA, Rutten FF: A practical guide for calculating indirect costs of disease. Pharmacoeconomics 1996,10(5):460–466. 10.2165/00019053-199610050-00003PubMedCrossRef

Titel: Impact of gastro-oesophageal reflux disease on work productivity despite therapy with proton pump inhibitors in Germany
verfasst von: M Gross
U Beckenbauer
J Burkowitz
H Walther
B Brueggenjuergen
Publikationsdatum: 01.12.2010
Verlag: BioMed Central
Erschienen in: European Journal of Medical Research / Ausgabe 3/2010
Elektronische ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-15-3-124

Springer Medizin

Abstract

Background

Aim

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2010

HAART and the liver: friend or foe?

An unsuspected ameloblastoma in the subpontic region of the mandible with consideration of pathogenesis from the radiographic course

The role of CCR5 in HCV infection

Optical coherence tomography for bladder cancer - ready as a surrogate for optical biopsy? - Results of a prospective mono-centre study

Precision of navigated and conventional open-wedge high tibial osteotomy in a cadaver study

Minimizing complications during retropubic radical prostatectomy - is ureteral stenting necessary?