Background
Methods
Search strategy
Selection criteria
Data extraction and quality assessment
Statistical analysis
Results
Characteristics of the studies
Author/year of publication | Country | Gender | Mean age (Y) | Intervention | Follow-up (d) | Study design | Outcomes assessed | |
---|---|---|---|---|---|---|---|---|
PRF | Control | |||||||
Gürbüzer/2010 [28] | Turkey | 7 males and 7 females | 24.92 ± 4.69Y | 14 | 14 | 28d | RCT, split-mouth | Osteoblastic activity |
Eshghpour/2014 [29] | Iran | 33 males and 45 females | 25.09 ± 4.25Y | 78 | 78 | 2 and 7d | RCT, split-mouth | Alveolar osteitis |
Baslarli/2015 [30] | Turkey | 7 males and 13 females | 23.9Y | 20 | 20 | 30 and 90d | RCT, split-mouth | Alveolar osteitis, osteoblastic activity |
Kumar/2015 [31] | India | NA | PRF:25.25 ± 4.2Y Control:27 ± 5.27Y | 16 | 15 | 90d | RCT | Trismus |
Ozgul/2015[32] | Turkey | 23 males and 33 females | NA | 56 | 56 | 1,3, and 7d | RCT, split-mouth | Pain, swelling |
Uyanık/2015 [33] | Cyprus | 4 males, 6 females | 22.65Y | 10 | 10 | 1,2,3, and 7d | RCT, split-mouth | Pain, swelling, trismus |
Bilginaylar/2016 [34] | Cyprus | 22 males and 37 females | PRF:21.75Y Control:22.5Y | 40 | 40 | 1,2,3, and 7d | RCT | Pain, swelling, trismus |
Dutta/2016 [19] | India | 27 males and 13 females | 27 ± 5Y | 10 | 10 | 3,7, and 14d | RCT | Pain, swelling, soft tissue healing |
Al-Hamed/2017 [16] | Egypt | 13 males and 34 females | 25.24 ± 7.04Y | 25 | 25 | 2,3,4,5,6, and 7d | RCT | Pain, alveolar osteitis, soft tissue healing |
Gülşen/2017 [21] | Turkey | 21 males and 9 females | 20.03Y | 30 | 30 | 1,2,3, and 7d | RCT, split-mouth | Pain |
Impact of PRF on mandibular third molar surgery recovery | ||||||
---|---|---|---|---|---|---|
Patient or population: patients with mandibular third molar surgery recovery Settings: outpatient Intervention: PRF Comparison: Non-PRF | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
Non-PRF | PRF | |||||
Pain Visual analog scale Follow-up: 1-7 days | The mean pain in the control groups was 7.52 | The mean pain in the intervention groups was 0.53 standard deviations lower (1.02 to 0.05 lower) | 322 (6 studies) | ⊕⊕⊝⊝ low1,2 | ||
Swelling A flexible ruler Follow-up: 1-7 days | The mean swelling in the control groups was 20.79 | The mean swelling in the intervention groups was 0.55 standard deviations lower (1.08 to 0.01 lower) | 212 (4 studies) | ⊕⊕⊕⊝ moderate3 | ||
Trismus Measuring the distance Follow-up: 1-7 days | The mean trismus in the control groups was 24.35 | The mean trismus in the intervention groups was 0.09 standard deviations lower (0.68 lower to 0.5 higher) | 131 (4 studies) | ⊕⊝⊝⊝ very low3,4,5 | ||
Alveolar osteitis Follow-up: 2-90 days | 179 per 1000 | 63 per 1000 (29 to 134) | RR 0.35 (0.16 to 0.75) | 246 (3 studies) | ⊕⊕⊝⊝ low1,5 | |
Osteoblastic activity Follow-up: 28-90 days | The mean osteoblastic activity in the control groups was 4.29 | The mean osteoblastic activity in the intervention groups was 0.05 higher (0.44 lower to 0.55 higher) | 68 (2 studies) | ⊕⊝⊝⊝ very low1,2,5 | ||
Soft tissue healing Follow-up: 2-14 days | The mean soft tissue healing in the intervention groups was 1.03 higher (0.32 lower to 2.38 higher) | 70 (2 studies) | ⊕⊕⊝⊝ low1,4 |
Quantitative synthesis
Outcomes | Subgroup | Number of trials | Effect (95% CI) | Estimate for overall effect | Heterogeneity |
---|---|---|---|---|---|
Pain | Total(1 day) | 4 | −0.38(−1.01,0.24) | P = 0.231 | I2 = 82.1%, P = 0.001 |
VAS(1 day) | 3 | −0.59 (−1.45, 0.27) | P = 0.181 | I2 = 86.1%, P = 0.001 | |
VAS and VRS(1 day) | 1 | 0.16 (− 0.35, 0.66) | P = 0.545 | ||
Total(3 day) | 6 | −0.53(−1.02,0.05) | P = 0.032 | I2 = 75.7%, P = 0.001 | |
VAS(3 day) | 5 | −0.67 (−1.26, − 0.08) | P = 0.026 | I2 = 78.6%, P = 0.001 | |
VAS and VRS (3 day) | 1 | −0.01 (− 0.51, 0.50) | P = 0.975 | ||
Total(7 day) | 4 | −1.05 (−2.14, 0.03) | P = 0.057 | I2 = 90.3%, P < 0.001 | |
VAS(7 day) | 3 | − 1.62 (−3.63, 0.39) | P = 0.113 | I2 = 93.2%, P < 0.001 | |
VAS and VRS (7 day) | 1 | 0.07 (− 0.44, 0.58) | P = 0.786 | ||
Trismus | Total | 4 | −0.19 (− 0.88, 0.50) | P = 0.596 | I2 = 73.1%, P = 0.011 |
Ustun method | 3 | −0.46 (− 0.99, 0.07) | P = 0.088 | I2 = 39.7%, P = 0.190 | |
Other | 1 | 0.77 (0.04, 1.50) | P = 0.039 |