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Erschienen in: Journal of Immigrant and Minority Health 4/2013

01.08.2013 | Original Paper

Implementation of an Interferon-Gamma Release Assay to Screen for Tuberculosis in Refugees and Immigrants

verfasst von: Terri Simpson, Julie Tomaro, Cynthia Jobb

Erschienen in: Journal of Immigrant and Minority Health | Ausgabe 4/2013

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Abstract

Despite increased use and accuracy of interferon-gamma release assays to detect latent tuberculosis infection (LTBI) in foreign-born arrivals in the United States, risk characteristics associated with positive results are not well characterized. We conducted a retrospective record review of 541 refugees and immigrants screened for LTBI with QuantiFERON®-TB Gold In-Tube (QFT-IT) at the Spokane Public Health Clinic from January 2, 2008, through June 5, 2009. Overall, 24 % of the arrivals had a positive QFT-IT, with the greatest frequency of positive results occurring in arrivals from Liberia (100 %) and Bhutan (39 %). More than the expected number of Burmese had indeterminate QFT-IT results. A positive QFT-IT was associated with age, race, ethnicity, and extent of TB burden in the country of origin. QFT-IT is useful to screen for LTBI in foreign-born arrivals, particularly middle-aged adults from high-burden countries. However, the QFT-IT may not yield meaningful results in groups with significant immunocompromise.
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Metadaten
Titel
Implementation of an Interferon-Gamma Release Assay to Screen for Tuberculosis in Refugees and Immigrants
verfasst von
Terri Simpson
Julie Tomaro
Cynthia Jobb
Publikationsdatum
01.08.2013
Verlag
Springer US
Erschienen in
Journal of Immigrant and Minority Health / Ausgabe 4/2013
Print ISSN: 1557-1912
Elektronische ISSN: 1557-1920
DOI
https://doi.org/10.1007/s10903-012-9748-6

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