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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Implication of human papillomavirus-66 in vulvar carcinoma: a case report

Journal of Medical Case Reports > Ausgabe 1/2011
Ioannis C Kotsopoulos, Georgios P Tampakoudis, Dimitrios G Evaggelinos, Anastasia I Nikolaidou, Panagiota A Fytili, Vasilios C Kartsiounis, Domniki K Gerasimidou
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-5-232) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

IK conceptualized the case report, collected and analyzed all data and wrote the major part of the manuscript. GT corrected the initial manuscript and wrote parts of the manuscript. DE was the major gynecologist (in cooperation with IK and GT) who cared for and conducted patient follow-up. DG and AN performed the histological examinations and corrected the pathological parts of the manuscript. Also, DG wrote parts of the manuscript and gave final approval of the manuscript. PF performed the HPV typing (Hybrid Capture 2 assay and CLINICAL ARRAYS Human Papillomavirus Kit testing) and corrected the cytological parts of the manuscript. VK reviewed the literature and wrote some parts of the Introduction. All authors read and approved the final manuscript.



Vulvar cancer in older women is seldom associated with human papillomavirus infection.

Case presentation

We present the case of an 80-year-old Greek Caucasian woman with an undetermined obstetric and gynecologic history. The patient underwent radical vulvectomy and bilateral inguinal lymphadenectomy for a vulvar carcinoma. A human papillomavirus infection was suggested on the basis of histological and cytological examinations followed by human papillomavirus DNA typing, which revealed the presence of human papillomavirus-66.


Even though human papillomavirus-16 and human papillomavirus-18 are most frequently implicated in the pathogenesis of vulvar carcinoma, human papillomavirus-66 can also be regarded as a causative factor. Suspicious lesions should be biopsied, and in the presence of carcinoma, vulvectomy with bilateral lymphadenectomy, if necessary, must be performed. Furthermore, polymerase chain reaction assay analysis with clinical arrays in cytological samples is an accurate test for the detection of a wide range of human papillomavirus genotypes and can be used to verify the infection and specify the human papillomavirus type implicated.

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