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Erschienen in: International Journal of Clinical Pharmacy 4/2016

01.08.2016 | Research Article

Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand

verfasst von: June M. Tordoff, Nagham J. Ailabouni, Dorothy P. Browne, Hesham S. Al-Sallami, Andrew R. Gray

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 4/2016

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Abstract

Background Despite warnings of possible serious events, and reports of little benefit, antipsychotic agents are commonly prescribed in residential care for older people with dementia. A residential care provider (RCP) in New Zealand sought to examine and improve prescribing in some of their facilities. Objective To examine changes following a range of interventions implemented by a RCP to improve the prescribing of antipsychotics. Setting Thirteen dementia and psychogeriatric units in New Zealand managed by a RCP. Method An audit (n = 228 residents) was undertaken in thirteen dementia and psychogeriatric units in New Zealand in July–September 2011. A modified Best Practice Advocacy Centre (bpacnz) tool was used to examine antipsychotic prescribing, the administration of “when required” (PRN) antipsychotic doses and antipsychotic-related documentation (e.g. documenting of “target behaviour identified” and “need to monitor for adverse effects”). Prescribing for some central nervous system agents and fractures and fall rates were also examined. Some educational, managerial, environmental, recreational and resident-specific interventions were implemented post-audit. The audit (n = 233) was repeated in July–September 2013. Main outcome measures: (1) Number of residents prescribed and administered antipsychotics (2) Documentation of antipsychotic-related information in residents’ notes. Results The administration of antipsychotics and prescribing of regular doses (±PRN) decreased about a quarter from 2011 to 2013: 50.4–38.2, and 49.1–36.5 % (ORs 0.60, 0.57 respectively, both p < 0.001), and prescribing for any antipsychotic dose (including PRN only) decreased: 60.5–50.6 % (OR 0.67, p = 0.003). Documenting of “target behaviour identified” significantly increased from 54.3 to 71.2 %, (OR 1.99, p = 0.017) and documenting of the “need to monitor for adverse effects” increased non-significantly (30.4–46.6 %, p = 0.098); both falling short of the 90 % goal set by bpacnz. Benzodiazepine prescribing significantly decreased [39.0–25.8 %, (OR 0.59, p < 0.001)]. Conclusions Following a range of interventions, antipsychotic prescribing, administration and some related documentation improved in dementia and psychogeriatric units in New Zealand. Future studies should aim to identify the most effective of these interventions so they can be considered for implementing in similar settings.
Literatur
2.
Zurück zum Zitat Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157(5):708–14.CrossRefPubMed Lyketsos CG, Steinberg M, Tschanz JT, Norton MC, Steffens DC, Breitner JC. Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging. Am J Psychiatry. 2000;157(5):708–14.CrossRefPubMed
3.
Zurück zum Zitat Zimmerman S, Sloane PD, Reed D. Dementia prevalence and care in assisted living. Health Aff (Millwood). 2014;33(4):658–66.CrossRef Zimmerman S, Sloane PD, Reed D. Dementia prevalence and care in assisted living. Health Aff (Millwood). 2014;33(4):658–66.CrossRef
4.
Zurück zum Zitat Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934–43.CrossRefPubMed Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934–43.CrossRefPubMed
5.
Zurück zum Zitat Schneeweiss S, Setoguchi S, Brookhart A, Dormuth C, Wang PS. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176(5):627–32.CrossRefPubMedPubMedCentral Schneeweiss S, Setoguchi S, Brookhart A, Dormuth C, Wang PS. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176(5):627–32.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Ballard C, Waite J, Birks J. Atypical anti-psychotics for aggression and psychosis in Alzheimer’s disease. Cochrane Database Syst Rev. 2006;1:CD003476.PubMed Ballard C, Waite J, Birks J. Atypical anti-psychotics for aggression and psychosis in Alzheimer’s disease. Cochrane Database Syst Rev. 2006;1:CD003476.PubMed
10.
Zurück zum Zitat Maher AR, Maglione M, Bagley S, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA. 2011;306(12):1359–69.CrossRefPubMed Maher AR, Maglione M, Bagley S, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA. 2011;306(12):1359–69.CrossRefPubMed
11.
Zurück zum Zitat Rolland Y, Andrieu S, Crochard A, Goni S, Hein C, Vellas B. Psychotropic drug consumption at admission and discharge of nursing home residents. J Am Med Dir Assoc. 2012;13(4):e7–12.CrossRefPubMed Rolland Y, Andrieu S, Crochard A, Goni S, Hein C, Vellas B. Psychotropic drug consumption at admission and discharge of nursing home residents. J Am Med Dir Assoc. 2012;13(4):e7–12.CrossRefPubMed
12.
Zurück zum Zitat Huber M, Kölzsch M, Rapp MA, et al. Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia. Pharmacopsychiatry. 2012;45(5):182–8.PubMed Huber M, Kölzsch M, Rapp MA, et al. Antipsychotic drugs predominate in pharmacotherapy of nursing home residents with dementia. Pharmacopsychiatry. 2012;45(5):182–8.PubMed
13.
Zurück zum Zitat Rattinger GB, Burcu M, Dutcher SK, et al. Pharmacotherapeutic management of dementia across settings of care. J Am Geriatr Soc. 2013;61(5):723–33.CrossRefPubMedPubMedCentral Rattinger GB, Burcu M, Dutcher SK, et al. Pharmacotherapeutic management of dementia across settings of care. J Am Geriatr Soc. 2013;61(5):723–33.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Tucker M, Hosford I. Use of psychotropic medicines in residential care facilities for older people in Hawke’s Bay, New Zealand. N Z Med J. 2008;121(1274):18–25.PubMed Tucker M, Hosford I. Use of psychotropic medicines in residential care facilities for older people in Hawke’s Bay, New Zealand. N Z Med J. 2008;121(1274):18–25.PubMed
15.
Zurück zum Zitat Jackson G, Gerard C, Minko N, Parsotam N. Variation in benzodiazepine and antipsychotic use in people aged 65 years and over in New Zealand. N Z Med J. 2014;127(1396):67–78.PubMed Jackson G, Gerard C, Minko N, Parsotam N. Variation in benzodiazepine and antipsychotic use in people aged 65 years and over in New Zealand. N Z Med J. 2014;127(1396):67–78.PubMed
21.
Zurück zum Zitat Parsons C, Haydock J, Mathie E, et al. Sedative load of medications prescribed for older people with dementia in care homes. BMC Geriatr. 2011;11(56). doi:10.1186/1471-2318-11-56. Parsons C, Haydock J, Mathie E, et al. Sedative load of medications prescribed for older people with dementia in care homes. BMC Geriatr. 2011;11(56). doi:10.​1186/​1471-2318-11-56.
22.
Zurück zum Zitat Nishtala PS, McLachlan AJ, Bell JS, Chen TF. Determinants of antipsychotic medication use among older people living in aged care homes in Australia. Int J Geriatr Psychiatry. 2010;25(5):449–57.CrossRefPubMed Nishtala PS, McLachlan AJ, Bell JS, Chen TF. Determinants of antipsychotic medication use among older people living in aged care homes in Australia. Int J Geriatr Psychiatry. 2010;25(5):449–57.CrossRefPubMed
23.
Zurück zum Zitat Chen Y, Briesacher BA, Field TS, Tjia J, Lau DT, Gurwitz JH. Unexplained variation across US nursing homes in antipsychotic prescribing rates. Arch Intern Med. 2010;170(1):89–95.CrossRefPubMedPubMedCentral Chen Y, Briesacher BA, Field TS, Tjia J, Lau DT, Gurwitz JH. Unexplained variation across US nursing homes in antipsychotic prescribing rates. Arch Intern Med. 2010;170(1):89–95.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Hughes CM, Donnelly A, Moyes SA, et al. “The way we do things around here”: an international comparison of treatment culture in nursing homes. J Am Med Dir Assoc. 2012;13(4):360–7.CrossRefPubMed Hughes CM, Donnelly A, Moyes SA, et al. “The way we do things around here”: an international comparison of treatment culture in nursing homes. J Am Med Dir Assoc. 2012;13(4):360–7.CrossRefPubMed
25.
Zurück zum Zitat Morrison A. Antipsychotic prescribing in nursing homes: an audit report. Qual Prim Care. 2009;17(5):359–62.PubMed Morrison A. Antipsychotic prescribing in nursing homes: an audit report. Qual Prim Care. 2009;17(5):359–62.PubMed
26.
Zurück zum Zitat Nishtala PS, McLachlan AJ, Bell JS, Chen TF. Psychotropic prescribing in long-term care facilities: impact of medication reviews and educational interventions. Am J Geriatr Psychiatry. 2008;16(8):621–32.CrossRefPubMed Nishtala PS, McLachlan AJ, Bell JS, Chen TF. Psychotropic prescribing in long-term care facilities: impact of medication reviews and educational interventions. Am J Geriatr Psychiatry. 2008;16(8):621–32.CrossRefPubMed
27.
Zurück zum Zitat Westbury J, Jackson S, Gee P, Peterson G. An effective approach to decrease antipsychotic and benzodiazepine use in nursing homes: the RedUSe project. Int Psychogeriatr. 2010;22(1):26–36.CrossRefPubMed Westbury J, Jackson S, Gee P, Peterson G. An effective approach to decrease antipsychotic and benzodiazepine use in nursing homes: the RedUSe project. Int Psychogeriatr. 2010;22(1):26–36.CrossRefPubMed
28.
Zurück zum Zitat Madhusoodanan S, Bogunovic OJ. Safety of benzodiazepines in the geriatric population. Expert Opin Drug Saf. 2004;3(5):485–9.CrossRefPubMed Madhusoodanan S, Bogunovic OJ. Safety of benzodiazepines in the geriatric population. Expert Opin Drug Saf. 2004;3(5):485–9.CrossRefPubMed
29.
Zurück zum Zitat American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.CrossRef American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.CrossRef
30.
Zurück zum Zitat Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer’s disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr. 2009;21(5):813–24.CrossRefPubMed Rodda J, Morgan S, Walker Z. Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer’s disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine. Int Psychogeriatr. 2009;21(5):813–24.CrossRefPubMed
31.
Zurück zum Zitat Nelson JC, Devanand DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc. 2011;59(4):577–85.CrossRefPubMed Nelson JC, Devanand DP. A systematic review and meta-analysis of placebo-controlled antidepressant studies in people with depression and dementia. J Am Geriatr Soc. 2011;59(4):577–85.CrossRefPubMed
32.
Zurück zum Zitat Tan L, Tan L, Wang HF, et al. Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and meta-analysis. Alzheimers Res Ther. 2015;7(1):20.CrossRefPubMedPubMedCentral Tan L, Tan L, Wang HF, et al. Efficacy and safety of atypical antipsychotic drug treatment for dementia: a systematic review and meta-analysis. Alzheimers Res Ther. 2015;7(1):20.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Coon JT, Abbott R, Rogers M, et al. Interventions to reduce inappropriate prescribing of antipsychotic medications in people with dementia resident in care homes: a systematic review. J Am Med Dir Assoc. 2014;15(10):706–18.CrossRef Coon JT, Abbott R, Rogers M, et al. Interventions to reduce inappropriate prescribing of antipsychotic medications in people with dementia resident in care homes: a systematic review. J Am Med Dir Assoc. 2014;15(10):706–18.CrossRef
34.
Zurück zum Zitat Fossey J, Masson S, Stafford J, Lawrence V, Corbett A, Ballard C. The disconnect between evidence and practice: a systematic review of person-centred interventions and training manuals for care home staff working with people with dementia. Int J Geriatr Psychiatry. 2014;29(8):797–807.CrossRefPubMed Fossey J, Masson S, Stafford J, Lawrence V, Corbett A, Ballard C. The disconnect between evidence and practice: a systematic review of person-centred interventions and training manuals for care home staff working with people with dementia. Int J Geriatr Psychiatry. 2014;29(8):797–807.CrossRefPubMed
35.
Zurück zum Zitat Kim DH, Brown RT, Ding EL, Kiel DP, Berry SD. Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials. J Am Geriatr Soc. 2011;59(6):1019–31.CrossRefPubMedPubMedCentral Kim DH, Brown RT, Ding EL, Kiel DP, Berry SD. Dementia medications and risk of falls, syncope, and related adverse events: meta-analysis of randomized controlled trials. J Am Geriatr Soc. 2011;59(6):1019–31.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Buckeridge D, Huang A, Hanley J, et al. Risk of injury associated with opioid use in older adults. J Am Geriatr Soc. 2010;58(9):664–70.CrossRef Buckeridge D, Huang A, Hanley J, et al. Risk of injury associated with opioid use in older adults. J Am Geriatr Soc. 2010;58(9):664–70.CrossRef
37.
Zurück zum Zitat Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952-60. Erratum in: Arch Intern Med. 2010;170(5):477. Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952-60. Erratum in: Arch Intern Med. 2010;170(5):477.
Metadaten
Titel
Improvements in the prescribing of antipsychotics in dementia and psychogeriatric units in New Zealand
verfasst von
June M. Tordoff
Nagham J. Ailabouni
Dorothy P. Browne
Hesham S. Al-Sallami
Andrew R. Gray
Publikationsdatum
01.08.2016
Verlag
Springer International Publishing
Erschienen in
International Journal of Clinical Pharmacy / Ausgabe 4/2016
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-016-0318-1

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