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16.08.2016 | Original Article

In vivo evaluation of cp Ti implants with modified surfaces by laser beam with and without hydroxyapatite chemical deposition and without and with thermal treatment: topographic characterization and histomorphometric analysis in rabbits

verfasst von: Thallita Pereira Queiroz, Rafael Scaf de Molon, Francisley Ávila Souza, Rogério Margonar, Anahi Herrera Aparecida Thomazini, Antônio Carlos Guastaldi, Eduardo Hochuli-Vieira

Erschienen in: Clinical Oral Investigations | Ausgabe 2/2017

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Abstract

Objective

We aimed to assess the surfaces of commercially pure titanium implants (cp Ti) with modified surfaces by laser beam (LS) with and without hydroxyapatite (HA) deposition, without (HAB) and with (HABT) thermal treatment. Furthermore, we have compared them with implants with surfaces modified by acid treatment (AS) and with machined surfaces (MS) utilizing histomorphometric and descriptive histologic analyses.

Material and methods

Surface topography characterization was analyzed by scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDX), and surface roughness (Ra) before implant installation. Forty-five rabbits received seventy-five implants in their left and right tibias and were randomly divided into five groups (n = 5 implants per group): (1) cp Ti implant modified by LS, (2) cp Ti implant modified by laser beam associated with HA deposition without heat treatment (HAB), (3) cp Ti implant modified by laser beam associated with HA deposition with heat treatment (HABT), (4) cp Ti implant with modified surface by means of acid treatment (Master Porous) commercially available (AS), and (5) cp Ti implant with MS commercially available. After 30, 60, and 90 days, the animals were euthanized and the implants and surrounding bone were removed and prepared by a non-decalcified histological process. The percentage of bone-to-implant contact (BIC) and the bone area fraction occupancy (BAFO) between the first three threads was evaluated to the higher cortical region.

Results

BIC (%) was statistically superior (p < 0.001) on the LS (69.36 ± 7.91, 71.67 ± 8.79, and 79.69 ± 3.3), HAB (73.22 ± 3.75, 69.48 ± 1.89, and 75.7 ± 4.62), and HABT (65.41 ± 5.51, 71.3 ± 2.5, and 79.68 ± 5.01) compared with AS (49.15 ± 5.76, 41.94 ± 2.85, and 57.18 ± 7.81) and MS (36.69 ± 7.24, 52.52 ± 2.75, and 51.31 ± 6.96) in the 30, 60, and 90-day periods, respectively. BAFO (%) of HAB at 30 days (90.17 ± 6.24) was statistically superior (p < 0.01) to all the other groups. At 60 and 90 days, BAFO of LS (87.17 ± 5.9 and 87.99 ± 2.52), HAB (85.95 ± 3.93 and 82.17 ± 3.65), and HABT (83.27 ± 1.44 and 88.67 ± 2.67) was higher than the AS (77.49 ± 5.83 and 76.42 ± 5.98) and MS (74.01 ± 4.68 and 73.81 ± 4.91).

Conclusions

Collectively, our data indicate that the modified surfaces LS, HAB, and HABT favored the interaction between bone and implant and increased bone formation. In addition, HAB showed higher biological behavior favoring the osseointegration.

Clinical relevance

Our study provides evidence that LS, HAB, and HABT-modified surfaces improved bone-to-implant contact and increased bone formation around osseointegrated implants compared to conventional machined implants favoring the osseointegration process.

Albrektsson T, Branemark PI, Hansson HA, Lindstrom J (1981) Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand 52:155–170CrossRefPubMed

Zarb GA, Schmitt A (1991) Osseointegration and the edentulous predicament. The 10-year-old Toronto study. Br Dent J 170:439–444CrossRefPubMed

Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG (2004) Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res 83:529–533CrossRefPubMed

Cho SA, Jung SK (2003) A removal torque of the laser-treated titanium implants in rabbit tibia. Biomaterials 24:4859–4863CrossRefPubMed

de Molon RS, Morais-Camilo JA, Verzola MH, Faeda RS, Pepato MT, Marcantonio E Jr (2013) Impact of diabetes mellitus and metabolic control on bone healing around osseointegrated implants: removal torque and histomorphometric analysis in rats. Clin Oral Implants Res 24:831–837CrossRefPubMed

Ellingsen JE (1998) Surface configurations of dental implants. Periodontol 2000(17):36–46CrossRef

Ellingsen JE, Thomsen P, Lyngstadaas SP (2006) Advances in dental implant materials and tissue regeneration. Periodontol 41:136–156CrossRef

Grossi-Oliveira GA, Antunes AA, Elias CN, Wennerberg A, Sennerby L, Salata LA (2015) Early osseointegration events on Neoss(R) ProActive and bimodal implants: a comparison of different surfaces in an animal model. Clin Implant Dent Relat Res 17:1060–1072CrossRefPubMed

Abagnale G, Steger M, Nguyen VH, Hersch N, Sechi A, Joussen S, Denecke B, Merkel R, Hoffmann B, Dreser A, Schnakenberg U, Gillner A, Wagner W (2015) Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages. Biomaterials 61:316–326CrossRefPubMed

10.

Kulkarni M, Patil-Sen Y, Junkar I, Kulkarni CV, Lorenzetti M, Iglic A (2015) Wettability studies of topologically distinct titanium surfaces. Colloids Surf B Biointerfaces 129:47–53CrossRefPubMed

11.

de Avila ED, Lima BP, Sekiya T, Torii Y, Ogawa T, Shi W, Lux R (2015) Effect of UV-photofunctionalization on oral bacterial attachment and biofilm formation to titanium implant material. Biomaterials 67:84–92CrossRefPubMedPubMedCentral

12.

Souza FA, Queiroz TP, Sonoda CK, Okamoto R, Margonar R, Guastaldi AC, Nishioka RS, Garcia Junior IR (2014) Histometric analysis and topographic characterization of cp Ti implants with surfaces modified by laser with and without silica deposition. J Biomed Mater Res B Appl Biomater 102:1677–1688CrossRefPubMed

13.

Albrektsson T, Wennerberg A (2004) Oral implant surfaces: part 1—review focusing on topographic and chemical properties of different surfaces and in vivo responses to them. Int J Prosthodont 17:536–543PubMed

14.

Buser D, Mericske-Stern R, Bernard JP, Behneke A, Behneke N, Hirt HP, Belser UC, Lang NP (1997) Long-term evaluation of non-submerged ITI implants. Part 1: 8-year life table analysis of a prospective multi-center study with 2359 implants. Clin Oral Implants Res 8:161–172CrossRefPubMed

15.

Li LH, Kong YM, Kim HW, Kim YW, Kim HE, Heo SJ, Koak JY (2004) Improved biological performance of Ti implants due to surface modification by micro-arc oxidation. Biomaterials 25:2867–2875CrossRefPubMed

16.

Faeda RS, Tavares HS, Sartori R, Guastaldi AC, Marcantonio E Jr (2009) Biological performance of chemical hydroxyapatite coating associated with implant surface modification by laser beam: biomechanical study in rabbit tibias. J Oral Maxillofac Surg 67:1706–1715CrossRefPubMed

17.

Lin A, Wang CJ, Kelly J, Gubbi P, Nishimura I (2009) The role of titanium implant surface modification with hydroxyapatite nanoparticles in progressive early bone-implant fixation in vivo. Int J Oral Maxillofac Implants 24:808–816PubMed

18.

Vercaigne S, Wolke JG, Naert I, Jansen JA (1998) Bone healing capacity of titanium plasma-sprayed and hydroxylapatite-coated oral implants. Clin Oral Implants Res 9:261–271CrossRefPubMed

19.

de Avila ED, de Molon RS, Spolidorio DMP, Mollo FD (2013) Implications of surface and bulk properties of abutment implants and their degradation in the health of periodontal tissue. Materials 6:5951–5966CrossRef

20.

de Avila ED, de Molon RS, Vergani CE, Mollo FD, Salih V (2014) The relationship between biofilm and physical-chemical properties of implant abutment materials for successful dental implants. Materials 7:3651–3662CrossRef

21.

Hao L, Lawrence J (2007) Wettability modification and the subsequent manipulation of protein adsorption on a Ti6Al4V alloy by means of CO2 laser surface treatment. J Mater Sci Mater Med 18:807–817CrossRefPubMed

22.

Norde W (1986) Adsorption of proteins from solution at the solid liquid interface. Adv Colloid Interf Sci 25:267–340CrossRef

23.

Gittens RA, Scheideler L, Rupp F, Hyzy SL, Geis-Gerstorfer J, Schwartz Z, Boyan BD (2014) A review on the wettability of dental implant surfaces II: biological and clinical aspects. Acta Biomater 10:2907–2918CrossRefPubMedPubMedCentral

24.

de Avila ED, de Molon RS, Lima BP, Lux R, Shi W, Junior MJ, Spolidorio DM, Vergani CE, de Assis Mollo Junior F (2016) Impact of physical chemical characteristics of abutment implant surfaces on bacteria adhesion. J Oral Implantol 42:153–158CrossRefPubMed

25.

Picraux ST, Pope LE (1984) Tailored surface modification by ion implantation and laser treatment. Science 226:615–622CrossRefPubMed

26.

Gaggl A, Schultes G, Muller WD, Karcher H (2000) Scanning electron microscopical analysis of laser-treated titanium implant surfaces--a comparative study. Biomaterials 21:1067–1073CrossRefPubMed

27.

Park EK, Lee YE, Choi JY, Oh SH, Shin HI, Kim KH, Kim SY, Kim S (2004) Cellular biocompatibility and stimulatory effects of calcium metaphosphate on osteoblastic differentiation of human bone marrow-derived stromal cells. Biomaterials 25:3403–3411CrossRefPubMed

28.

Queiroz TP, Souza FA, Guastaldi AC, Margonar R, Garcia-Junior IR, Hochuli-Vieira E (2013) Commercially pure titanium implants with surfaces modified by laser beam with and without chemical deposition of apatite. Biomechanical and topographical analysis in rabbits. Clin Oral Implants Res 24:896–903CrossRefPubMed

29.

Sisti KE, de Rossi R, Antoniolli AM, Aydos RD, Guastaldi AC, Queiroz TP, Garcia IR Jr, Piattelli A, Tavares HS (2012) Surface and biomechanical study of titanium implants modified by laser with and without hydroxyapatite coating, in rabbits. J Oral Implantol 38:231–237CrossRefPubMed

30.

Sisti KE, Piattelli A, Guastaldi AC, Queiroz TP, de Rossi R (2013) Nondecalcified histologic study of bone response to titanium implants topographically modified by laser with and without hydroxyapatite coating. Int J Periodontics Restorative Dent 33:689–696CrossRefPubMed

31.

Daculsi G, Laboux O, Malard O, Weiss P (2003) Current state of the art of biphasic calcium phosphate bioceramics. J Mater Sci Mater Med 14:195–200CrossRefPubMed

32.

Davies JE (2003) Understanding peri-implant endosseous healing. J Dent Educ 67:932–949PubMed

33.

Barrere F, van der Valk CM, Dalmeijer RA, Meijer G, van Blitterswijk CA, de Groot K, Layrolle P (2003) Osteogenecity of octacalcium phosphate coatings applied on porous metal implants. J Biomed Mater Res A 66:779–788CrossRefPubMed

34.

Barrere F, van der Valk CM, Dalmeijer RA, van Blitterswijk CA, de Groot K, Layrolle P (2003) In vitro and in vivo degradation of biomimetic octacalcium phosphate and carbonate apatite coatings on titanium implants. J Biomed Mater Res A 64:378–387CrossRefPubMed

35.

Barrere F, van der Valk CM, Meijer G, Dalmeijer RA, de Groot K, Layrolle P (2003) Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats. J Biomed Mater Res B Appl Biomater 67:655–665CrossRefPubMed

36.

Bourgeois B, Laboux O, Obadia L, Gauthier O, Betti E, Aguado E, Daculsi G, Bouler JM (2003) Calcium-deficient apatite: a first in vivo study concerning bone ingrowth. J Biomed Mater Res A 65:402–408CrossRefPubMed

37.

Junker R, Dimakis A, Thoneick M, Jansen JA (2009) Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 20(Suppl 4):185–206CrossRefPubMed

38.

Strnad Z, Strnad J, Povysil C, Urban K (2000) Effect of plasma-sprayed hydroxyapatite coating on the osteoconductivity of commercially pure titanium implants. Int J Oral Maxillofac Implants 15:483–490PubMed

39.

Vidigal GM Jr, Aragones LC, Campos A Jr, Groisman M (1999) Histomorphometric analyses of hydroxyapatite-coated and uncoated titanium dental implants in rabbit cortical bone. Implant Dent 8:295–302CrossRefPubMed

40.

Palka V, Postrkova E, Koerten HK (1998) Some characteristics of hydroxylapatite powder particles after plasma spraying. Biomaterials 19:1763–1772CrossRefPubMed

41.

Aparecida AH, Fook MV, Guastaldi AC (2009) Biomimetic apatite formation on ultra-high molecular weight polyethylene (UHMWPE) using modified biomimetic solution. J Mater Sci Mater Med 20:1215–1222CrossRefPubMed

42.

Forsgren J, Svahn F, Jarmar T, Engqvist H (2007) Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates. Acta Biomater 3:980–984CrossRefPubMed

43.

Oyane A, Onuma K, Ito A, Kim HM, Kokubo T, Nakamura T (2003) Formation and growth of clusters in conventional and new kinds of simulated body fluids. J Biomed Mater Res A 64:339–348CrossRefPubMed

44.

Wang X, Li Y, Lin J, Hodgson PD, Wen C (2008) Effect of heat-treatment atmosphere on the bond strength of apatite layer on Ti substrate. Dent Mater 24:1549–1555CrossRefPubMed

45.

Moritz N, Jokinen M, Peltola T, Areva S, Yli-Urpo A (2003) Local induction of calcium phosphate formation on TiO2 coatings on titanium via surface treatment with a CO2 laser. J Biomed Mater Res A 65:9–16CrossRefPubMed

46.

Palmquist A, Emanuelsson L, Branemark R, Thomsen P (2011) Biomechanical, histological and ultrastructural analyses of laser micro- and nano-structured titanium implant after 6 months in rabbit. J Biomed Mater Res B Appl Biomater 97:289–298CrossRefPubMed

47.

Souza FA, Queiroz TP, Guastaldi AC, Garcia-Junior IR, Magro-Filho O, Nishioka RS, Sisti KE, Sonoda CK (2013) Comparative in vivo study of commercially pure Ti implants with surfaces modified by laser with and without silicate deposition: biomechanical and scanning electron microscopy analysis. J Biomed Mater Res B Appl Biomater 101:76–84CrossRefPubMed

48.

Gandolfi MG, Taddei P, Siboni F, Perrotti V, Iezzi G, Piattelli A, Prati C (2015) Micro-topography and reactivity of implant surfaces: an in vitro study in simulated body fluid (SBF). Microsc Microanal 21:190–203CrossRefPubMed

49.

Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2012) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Osteoarthr Cartil 20:256–260CrossRefPubMed

50.

Giro G, Coelho PG, Pereira RM, Jorgetti V, Marcantonio E Jr, Orrico SR (2011) The effect of oestrogen and alendronate therapies on postmenopausal bone loss around osseointegrated titanium implants. Clin Oral Implants Res 22:259–264CrossRefPubMed

51.

Zagury R, Harari ND, Conz MB, Soares Gde A, Vidigal GM Jr (2007) Histomorphometric analyses of bone interface with titanium-aluminum-vanadium and hydroxyapatite-coated implants by biomimetic process. Implant Dent 16:290–296CrossRefPubMed

52.

Albrektsson T (2008) Hard tissue implant interface. Aust Dent J 53(Suppl 1):S34–S38CrossRefPubMed

53.

Albrektsson T, Wennerberg A (2004) Oral implant surfaces: part 2--review focusing on clinical knowledge of different surfaces. Int J Prosthodont 17:544–564PubMed

54.

Amoroso PF, Adams RJ, Waters MG, Williams DW (2006) Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an in vitro study. Clin Oral Implants Res 17:633–637CrossRefPubMed

55.

Berglundh T, Persson L, Klinge B (2002) A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years. J Clin Periodontol 29(Suppl 3):197–212 discussion 232-193CrossRefPubMed

56.

Mombelli A (2002) Microbiology and antimicrobial therapy of peri-implantitis. Periodontol 2000(28):177–189CrossRef

57.

Mombelli A, Muller N, Cionca N (2012) The epidemiology of peri-implantitis. Clin Oral Implants Res 23(Suppl 6):67–76CrossRefPubMed

58.

Norowski PA Jr, Bumgardner JD (2009) Biomaterial and antibiotic strategies for peri-implantitis: a review. J Biomed Mater Res B Appl Biomater 88:530–543CrossRefPubMed

59.

Quirynen M, De Soete M, van Steenberghe D (2002) Infectious risks for oral implants: a review of the literature. Clin Oral Implants Res 13:1–19CrossRefPubMed

60.

Quirynen M, De Soete M, van Steenberghe D (1999) Intra-oral plaque formation on artificial surfaces. In: Lang NP, Karring T, Lindhe J (eds) Book title. Quintessence Books, Berlin

61.

Bollen CM, Lambrechts P, Quirynen M (1997) Comparison of surface roughness of oral hard materials to the threshold surface roughness for bacterial plaque retention: a review of the literature. Dent Mater 13:258–269CrossRefPubMed

62.

Iezzi G, Scarano A, Petrone G, Piattelli A (2007) Two human hydroxyapatite-coated dental implants retrieved after a 14-year loading period: a histologic and histomorphometric case report. J Periodontol 78:940–947CrossRefPubMed

63.

Caulier H, van der Waerden JP, Wolke JG, Kalk W, Naert I, Jansen JA (1997) A histological and histomorphometrical evaluation of the application of screw-designed calciumphosphate (Ca-P)-coated implants in the cancellous maxillary bone of the goat. J Biomed Mater Res 35:19–30CrossRefPubMed

64.

Soballe K (1993) Hydroxyapatite ceramic coating for bone implant fixation. Mechanical and histological studies in dogs. Acta Orthop Scand Suppl 255:1–58CrossRefPubMed

65.

Xuereb M, Camilleri J, Attard NJ (2015) Systematic review of current dental implant coating materials and novel coating techniques. Int J Prosthodont 28:51–59CrossRefPubMed

66.

Guo L, Li H (2004) Fabrication and characterization of thin nano-hydroxyapatite coatings on titanium. Surf Coat Technol 185:268–274CrossRef

67.

Barrere F, Layrolle P, Van Blitterswijk CA, De Groot K (2001) Biomimetic coatings on titanium: a crystal growth study of octacalcium phosphate. J Mater Sci Mater Med 12:529–534CrossRefPubMed

68.

Freire AR, Rossi AC, Queiroz TP, Gulinelli JL, Souza FA, Margonar R, Garcia-Junior IR, Hochuli-Vieira E, Okamoto R (2012) Histometric analysis of bone repair in bone-implant interface using a polylactic/polyglycolic acid copolymer associated with implants in rabbit tibia. J Oral Implantol 38 Spec No:449–457CrossRefPubMed

69.

Kim HW, Koh YH, Li LH, Lee S, Kim HE (2004) Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol-gel method. Biomaterials 25:2533–2538CrossRefPubMed

70.

McGlumphy EA, Peterson LJ, Larsen PE, Jeffcoat MK (2003) Prospective study of 429 hydroxyapatite-coated cylindric omniloc implants placed in 121 patients. Int J Oral Maxillofac Implants 18:82–92PubMed

71.

Wennerberg A, Albrektsson T (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res 20(Suppl 4):172–184CrossRefPubMed

72.

Cooper LF (2000) A role for surface topography in creating and maintaining bone at titanium endosseous implants. J Prosthet Dent 84:522–534CrossRefPubMed

73.

Le Guehennec L, Soueidan A, Layrolle P, Amouriq Y (2007) Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 23:844–854CrossRefPubMed

74.

Meirelles L, Arvidsson A, Andersson M, Kjellin P, Albrektsson T, Wennerberg A (2008) Nano hydroxyapatite structures influence early bone formation. J Biomed Mater Res A 87:299–307CrossRefPubMed

75.

Nayar S, Sinha MK, Basu D, Sinha A (2006) Synthesis and sintering of biomimetic hydroxyapatite nanoparticles for biomedical applications. J Mater Sci Mater Med 17:1063–1068CrossRefPubMed

76.

Zhang Q, Chen J, Feng J, Cao Y, Deng C, Zhang X (2003) Dissolution and mineralization behaviors of HA coatings. Biomaterials 24:4741–4748CrossRefPubMed

77.

de Molon RS, de Avila ED, Boas Nogueira AV, Chaves de Souza JA, Avila-Campos MJ, de Andrade CR, Cirelli JA (2014) Evaluation of the host response in various models of induced periodontal disease in mice. J Periodontol 85:465–477CrossRefPubMed

78.

de Molon RS, de Avila ED, Cirelli JA (2013) Host responses induced by different animal models of periodontal disease: a literature review. J Investig Clin Dent 4:211–218CrossRefPubMed

79.

Mapara M, Thomas BS, Bhat KM (2012) Rabbit as an animal model for experimental research. Dent Res J (Isfahan) 9:111–118CrossRef

80.

de Molon RS, Mascarenhas VI, de Avila ED, Finoti LS, Toffoli GB, Spolidorio DM, Scarel-Caminaga RM, Tetradis S, Cirelli JA (2016) Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice. Clin Oral Investig 20:1203–1216

81.

Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Carlson ME, Gonzalez O, Boechat MI (1988) Effect of sex steroids on peak bone density of growing rabbits. Am J Phys 255:E416–E421

Titel: In vivo evaluation of cp Ti implants with modified surfaces by laser beam with and without hydroxyapatite chemical deposition and without and with thermal treatment: topographic characterization and histomorphometric analysis in rabbits
verfasst von: Thallita Pereira Queiroz
Rafael Scaf de Molon
Francisley Ávila Souza
Rogério Margonar
Anahi Herrera Aparecida Thomazini
Antônio Carlos Guastaldi
Eduardo Hochuli-Vieira
Publikationsdatum: 16.08.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 2/2017
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-016-1936-7

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In vivo evaluation of cp Ti implants with modified surfaces by laser beam with and without hydroxyapatite chemical deposition and without and with thermal treatment: topographic characterization and histomorphometric analysis in rabbits

Abstract

Objective

Material and methods

Results

Conclusions

Clinical relevance

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Abstract

Objective

Material and methods

Results

Conclusions

Clinical relevance

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