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25.01.2024 | Original Article

Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?

verfasst von: Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Harjeet Singh, Piyush Aggarwal, Harmandeep Singh, Thakur Deen Yadav, Ritambhra Nada, Vikas Gupta, Rajesh Gupta

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 3/2024

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Abstract

Purpose

Incidental gallbladder carcinoma (IGBC) is diagnosed in post-cholecystectomy specimens for benign indications, where the role of 2-fluro-2-deoxyglucose positron emission tomography/computed tomography(FDG-PET/CT) is not clearly defined. The present study aimed to assess the benefits of staging and prognosticating with FDG-PET/CT in IGBC.

Materials and Methods

A retrospective observational study from a tertiary-care center from January 2010 to July 2020 was performed. The demographic, clinical, histopathological, and treatment-related histories were collected. FDG-PET/CT-image findings were compared with survival outcomes through telephonic follow-up. The chi-square test was used for comparing frequencies. The univariate and multivariate survival estimates were analyzed using the Kaplan–Meier analysis and the Cox-proportional hazard model, respectively. Log-rank test was used to compare the Kaplan–Meier curves.

Results

The study included 280 postcholecystectomy participants (mean age: 52 ± 11 years; women: 227) of whom 52.1% had open surgery(146/280). Residual disease in the gallbladder fossa (54.8% vs. 36.6%, p = 0.002) and liver infiltration (32.9% vs. 22.4%, p = 0.05) were seen more frequently in open surgery compared to laparoscopic surgery, while anterior abdominal wall deposits were more common in laparoscopy(35.1% vs. 24%,p = 0.041). FDG-PET/CT changed the management in 10% (n = 28) of patients compared to contrast-enhanced CT. The median survival was 14 months (95%CI-10.3–17.7). A higher stage of the disease on the FDG-PET/CT (loco-regional disease-HR 4.86, p = 0.006; metastatic disease-HR 7.53, p < 0.001) and the presence of liver infiltration (HR-1.92, p = 0.003) were independent predictors of poor survival outcomes.

Conclusion

FDG-PET/CT detects residual and metastatic disease in patients with IGBC, enabling the institution of appropriate management and acting as a tool for prognostication of survival.

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Titel: Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?
verfasst von: Venkata Subramanian Krishnaraju
Rajender Kumar
Bhagwant Rai Mittal
Harjeet Singh
Piyush Aggarwal
Harmandeep Singh
Thakur Deen Yadav
Ritambhra Nada
Vikas Gupta
Rajesh Gupta
Publikationsdatum: 25.01.2024
Verlag: Springer Nature Singapore
Erschienen in: Nuclear Medicine and Molecular Imaging / Ausgabe 3/2024
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI: https://doi.org/10.1007/s13139-024-00841-w

Springer Medizin

Abstract

Purpose

Materials and Methods

Results

Conclusion

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