Background
Methods
Clinical isolates
Results and discussion
NTM species | No. of isolates (% of total isolates) | No. of isolates (% of species isolates) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient age range | Site of isolation | |||||||||||||
1–10 | 11–20 | 21–30 | 31–40 | 41–50 | 51–60 | 61–70 | 71–80 | >80 | Respiratory tract | Blood | Lymph node | Othera
| ||
M. avium
| 61 (41.5) | 8 (13.1) | 2 (3.3) | 1 (1.6) | – | 8 (13.1) | 7 (11.5) | 9 (14.8) | 20 (32.8) | 6 (9.8) | 40 (65.6) | 4 (6.6) | 11 (18.0) | 6 (9.8) |
M. intracellulare
| 21 (14.3) | 3 (14.3) | – | – | 2 (9.5) | – | 2 (9.5) | 5 (23.8) | 6 (28.6) | 3 (14.3) | 17 (81.0) | – | 4 (19.0) | – |
M. gordonae
| 17 (11.6) | – | – | – | 3 (17.6) | 4 (23.5) | 2 (11.8) | 3 (17.6) | 4 (23.5) | 1 (5.9) | 14 (82.4) | – | – | 3 (17.6) |
M. xenopi
| 14 (9.5) | – | – | – | 5 (35.7) | 2 (14.3) | 2 (14.3) | 4 (28.6) | – | 1 (7.1) | 14 (100.0) | – | – | – |
M. fortuitum
| 10 (6.8) | – | – | – | – | 1 (10.0) | 2 (20.0) | 3 (30.0) | 4 (40.0) | – | 7 (70.0) | – | – | 3 (30.0) |
M. kansasii
| 7 (4.8) | – | – | 1 (14.3) | – | – | 1 (14.3) | 4 (57.1) | 1 (14.3) | – | 7 (100.0) | – | – | – |
M. celatum
| 3 (2.0) | 1 (33.3) | – | – | – | – | – | 1 (33.3) | 1 (33.3) | – | 2 (66.6) | – | 1 (33.3) | – |
M. abscessus
| 2 (1.4) | – | – | – | – | – | – | – | 1 (50.0) | 1 (50.0) | 1 (50.0) | – | – | 1 (50.0) |
M. chelonae
| 2 (1.4) | – | – | – | 1 (50.0) | 1 (50.0) | – | – | – | – | 2 (100.0) | – | – | – |
M. marinum
| 2 (1.4) | – | – | – | – | 2 (100.0) | – | – | – | – | – | – | – | 2 (100.0) |
M. lentiflavum
| 2 (1.4) | – | – | – | – | – | – | 2 (100.0) | – | – | 2 (100.0) | – | – | – |
M. simiae
| 2 (1.4) | – | – | – | – | – | 1 (50.0) | – | 1 (50.0) | – | 2 (100.0) | – | – | – |
M. scrofulaceum
| 1 (0.7) | – | – | – | – | – | –– | – | 1 (100.0) | – | 1 (100.0) | – | – | – |
M. triplex
| 1 (0.7) | – | – | – | – | – | – | – | – | 1 (100.0) | 1 (100.0) | – | – | – |
M. phocaicum
| 1 (0.7) | – | – | – | – | – | – | – | – | 1 (100.0) | 1 (100.0) | – | – | – |
M. bolletii
| 1 (0.7) | – | – | – | – | – | – | – | 1 (100.0) | – | 1 (100.0) | – | – | – |
Total | 147 (100.0) | 12 (8.2) | 2 (1.4) | 2 (1.4) | 11 (7.5) | 18 (12.2) | 17 (11.6) | 31 (21.1) | 40 (27.2) | 14 (9.5) | 112 (76.2) | 4 (2.7) | 16 (10.9) | 15 (10.2) |
Setting | Years | Prevalent NTM species | % of total isolates | Trend | Reference |
---|---|---|---|---|---|
Tuscany (Italy) | 2004–2014 |
M. avium
| 41.5 | Increase | This study |
M. intracellulare
| 14.3 | ||||
M. gordonae
| 11.6 | ||||
England, Wales and Northern Ireland | 1995–2006 |
M. avium-intracellulare
| 42.9 | Increase | 9 |
M. malmoense
| 13.7 | ||||
M. kansasii
| 12.5 | ||||
Scotland | 2000–2010 |
M. avium complex | 48.1 | No clear trend | 13 |
M. malmoense
| 17.7 | ||||
M. abscessus
| 9.8 | ||||
The Netherlands | 2000–2006 |
M. avium complex | 39.0 | Increase | 14 |
M. gordonae
| 14.1 | ||||
M. kansasii
| 7.4 | ||||
Croatia | 2006–2010 |
M. gordonae
| 42.9 | Increase | 11 |
M. xenopi
| 15.5 | ||||
M. fortuitum
| 11.5 | ||||
Athens (Greece) | 2007–2013 |
M. gordonae
| 13.9 | No trend | 20 |
M. avium
| 13.1 | ||||
M. fortuitum
| 12.2 | ||||
Virginia (USA) | 2001–2009 |
M. avium complex | 40.9 | Increase | 22 |
M. gordonae
| 28.7 | ||||
M. abscessus
| 4.5 | ||||
Oregon (USA) | 2007–2012 |
M. avium-intracellulare
| 86 | Increase | 21 |
M. chelonae/abscessus
| 6 | ||||
Shangai (China) | 2008–2012 |
M. kansasii
| 45.0 | Increase | 23 |
M. intracellulare
| 20.8 | ||||
M. chelonae/abscessus
| 14.9 | ||||
Cheonan (Korea) | 2005–2011 |
M. intracellulare
| 51.3 | Increase | 24 |
M. avium
| 14.7 | ||||
M. kansasii
| 7.8 | ||||
South Korea | 2001–2011 |
M. avium complex | 53 | Increase | 25 |
M. abscessus-massiliense
| 25 | ||||
M. fortuitum
| 6 |