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01.01.2012 | Review Article

Increased glucose metabolism by FDG-PET correlates with reduced tumor angiogenesis in oral squamous cell carcinoma

verfasst von: Mikiko Nakamura, Yoshimasa Kitagawa, Yutaka Yamazaki, Hironobu Hata, Motoko Kotsuji, Yasuhisa Fujibayashi, Hidehiko Okazawa, Yoshiharu Yonekura, Kazuo Sano

Erschienen in: Odontology | Ausgabe 1/2012

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Abstract

Hypoxia is known to have been related with angiogenesis and glycolysis, and may have an influence on tumor treatment effect. Because glucose utilization is higher in malignant cells than that in normal cells, dynamic glucose metabolism of tumor has been evaluated by means of [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET). To investigate the significance of tumor vascularization in oral squamous cell carcinoma, we compared tumor angiogenesis with the FDG-PET findings. Twenty patients underwent FDG-PET. For the quantitative evaluation of FDG uptake in each tumor, the mean standardized uptake value (SUV) was calculated. Microvessel structures labeled with CD34 antigen were investigated in pretreatment biopsy specimens. Using an image analyzer, we calculated the following microvessel parameters: the ratio of the total number of microvessels (TN) to tumor area (TA), the ratio of the total microvessel perimeter (TP) to the TA, and the ratio of the tumor tissue area more than 150 μm distant from each microvessel (hypoxic ratio, %). The SUV was compared with the above parameters. Simple regression analysis revealed a statistical significance between the SUV and the TN:TA ratio (p = 0.046), as well as between the SUV and the TP:TA ratio (p = 0.0206). The SUV was found to be inversely related to the TN:TA and TP:TA ratios. Elevated glucose metabolism assessed by FDG-PET correlated with reduced vascularization. Higher glucose metabolism might therefore reflect a state of hypoxia.

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Titel: Increased glucose metabolism by FDG-PET correlates with reduced tumor angiogenesis in oral squamous cell carcinoma
verfasst von: Mikiko Nakamura
Yoshimasa Kitagawa
Yutaka Yamazaki
Hironobu Hata
Motoko Kotsuji
Yasuhisa Fujibayashi
Hidehiko Okazawa
Yoshiharu Yonekura
Kazuo Sano
Publikationsdatum: 01.01.2012
Verlag: Springer Japan
Erschienen in: Odontology / Ausgabe 1/2012
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-011-0024-3

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Increased glucose metabolism by FDG-PET correlates with reduced tumor angiogenesis in oral squamous cell carcinoma

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