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01.12.2016 | Research article | Ausgabe 1/2016 Open Access

BMC Infectious Diseases 1/2016

Initiation and completion rates for latent tuberculosis infection treatment: a systematic review

Zeitschrift:
BMC Infectious Diseases > Ausgabe 1/2016
Autoren:
Andreas Sandgren, Marije Vonk Noordegraaf-Schouten, Femke van Kessel, Anke Stuurman, Anouk Oordt-Speets, Marieke J. van der Werf
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12879-016-1550-y) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

MVN, AS and MvdW designed the review and search strategy. FvK and ALS searched the literature, selected the studies, extracted and analyzed data. MVN and AO controlled the quality of the review process. MVN, AO and MvdW assessed the quality of data analysis. ALS, AO, MVN and AS drafted the manuscript. MVN, AO, FvK, ALS, AS and MvdW edited the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Control of latent tuberculosis infection (LTBI) is an important step towards tuberculosis elimination. Preventive treatment will prevent the development of disease in most cases diagnosed with LTBI. However, low initiation and completion rates affect the effectiveness of preventive treatment. The objective was to systematically review data on initiation rates and completion rates for LTBI treatment regimens in the general population and specific populations with LTBI.

Methods

A systematic review of the literature (PubMed, Embase) published up to February 2014 was performed.

Results

Forty-five studies on initiation rates and 83 studies on completion rates of LTBI treatment were found. These studies provided initiation rates (IR) and completion rates (CR) in people with LTBI among the general population (IR 26–99 %, CR 39–96 %), case contacts (IR 40–95 %, CR 48–82 %), healthcare workers (IR 47–98 %, CR 17–79 %), the homeless (IR 34–90 %, CR 23–71 %), people who inject drugs (IR 52–91 %, CR 38–89 %), HIV-infected individuals (IR 67–92 %, CR 55–95 %), inmates (IR 7–90 %, CR 4–100 %), immigrants (IR 23–97 %, CR 7–86 %), and patients with comorbidities (IR 82–93 %, CR 75–92 %). Generally, completion rates were higher for short than for long LTBI treatment regimens.

Conclusion

Initiation and completion rates for LTBI treatment regimens were frequently suboptimal and varied greatly within and across different populations.
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