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Current Oncology Reports
Erschienen in: Current Oncology Reports 5/2021

01.05.2021 | Breast Cancer (AS Zimmer, Section Editor)

Integrating Adjuvant Radiation with Post-Neoadjuvant Therapies in Early Breast Cancer

verfasst von: Max S. Mano, Leandro Jonata C. Oliveira, Samir A. Hanna

Erschienen in: Current Oncology Reports | Ausgabe 5/2021

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Abstract

Purpose of review

Because of the strong prognostic value of pathologic complete response (pCR) in early breast cancer (EBC), patients who fail to achieve this outcome have increasingly been eligible to a new treatment modality, namely post-neoadjuvant systemic therapy (PNT). However, adjuvant radiation therapy (RT) retains a crucial role in EBC, and also needs to be timely administered to patients. To address how modern PNT optimally integrates with adjuvant RT is therefore the purpose of this review.

Recent Findings

How PNT administration optimally integrates with adjuvant RT has varied depending on the type of systemic therapy employed. The introduction of novel “targeted” agents has created new challenges, as for many of them limited information is available on the feasibility of concurrent systemic and RT administration or their optimal sequencing.

Summary

PNT and RT are both of utmost importance to the management of EBC and need to be timely and safely administered to patients. The optimal strategy to integrate these modalities may vary according to the type of PNT agent and other factors.
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Metadaten
Titel
Integrating Adjuvant Radiation with Post-Neoadjuvant Therapies in Early Breast Cancer
verfasst von
Max S. Mano
Leandro Jonata C. Oliveira
Samir A. Hanna
Publikationsdatum
01.05.2021
Verlag
Springer US
Erschienen in
Current Oncology Reports / Ausgabe 5/2021
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-021-01050-w

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