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Experimental Brain Research

Erschienen in:

01.05.2008 | Research Article

Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation

verfasst von: J. Florian M. Müller-Dahlhaus, Yuriy Orekhov, Yali Liu, Ulf Ziemann

Erschienen in: Experimental Brain Research | Ausgabe 3/2008

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Abstract

Paired associative stimulation (PAS) can increase motor cortical excitability, possibly by long-term potentiation (LTP)-like mechanisms. As the capability of the cortex for plasticity decreases with age, we were interested here in testing interindividual variability and age-dependency of the PAS effect. Motor-evoked potentials (MEPs) were recorded from the resting right abductor pollicis brevis muscle before and for 30 min after PAS in 27 healthy subjects (22–71 years of age). PAS consisted of 225 pairs (rate, 0.25 Hz) of right median nerve stimulation followed at an interval equaling the individual N20-latency of the median nerve somatosensory-evoked cortical potential plus 2 ms by transcranial magnetic stimulation of the hand area of left primary motor cortex (PAS_N20+2). The PAS_N20+2-induced changes in MEP amplitude (ratio post PAS/pre PAS) were highly variable (1.00 ± 0.07, range 0.36–1.68). Fourteen subjects showed the expected LTP-like MEP increase (responders) while 13 subjects showed a long-term depression (LTD)-like MEP decrease (non-responders). Responders had a significantly lower resting motor threshold (RMT) and minimum stimulus intensity to elicit MEPs of 1 mV (MEP_1 mV) than non-responders. RMT and MEP_1 mV correlated significantly negatively with the PAS_N20+2 effect. The absolute PAS_N20+2 effect size irrespective of its direction decreased with age (r = −0.57, P = 0.002), i.e., LTP-like and LTD-like plasticity were large in young subjects but substantially smaller in elderly subjects. In conclusion, measures of motor cortical excitability (RMT, MEP_1 mV) and age determine direction and magnitude of PAS effects in individual subjects.

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Titel: Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation
verfasst von: J. Florian M. Müller-Dahlhaus
Yuriy Orekhov
Yali Liu
Ulf Ziemann
Publikationsdatum: 01.05.2008
Verlag: Springer-Verlag
Erschienen in: Experimental Brain Research / Ausgabe 3/2008
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-008-1319-7

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