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12.12.2017 | Research Letter

Intermittent administration of PTH induces the expression of osteocalcin and BMP-2 on choroid plexus cells associated with suppression of sclerostin, TGF-β1, and Na⁺K⁺ATPase

verfasst von: Allan Fernando Giovanini, Isabella Göhringer, Rosangela Tavella, Manuelly Cristiny Linzmeyer, Thaynara Fernanda Priesnitz, Luana Mordask Bonetto, Rafaela Guimarães Resende, Rafaela Scariot, João Cesar Zielak

Erschienen in: Endocrine | Ausgabe 3/2018

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Excerpt

The parathyroid hormone (PTH) is a key hormone that acts on the regulation of calcium homeostasis and bone turnover. Despite evidence that this hormone has a dual action, for example, anabolic or catabolic effects, researchers have described that when the PTH is administrated in an intermittent form, it acts in favor of bone formation, which is why the Food and Drug Administration supports it for the treatment of osteoporosis [1]. According to this premise, some experiments with model animals have reinforced the hypothesis that this therapeutic approach may be a likely alternative to induce osteoneogenesis in areas that have been lost due to trauma, intra bonny cysts, or neoplasia [2]. …

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Titel: Intermittent administration of PTH induces the expression of osteocalcin and BMP-2 on choroid plexus cells associated with suppression of sclerostin, TGF-β1, and Na+K+ATPase
verfasst von: Allan Fernando Giovanini
Isabella Göhringer
Rosangela Tavella
Manuelly Cristiny Linzmeyer
Thaynara Fernanda Priesnitz
Luana Mordask Bonetto
Rafaela Guimarães Resende
Rafaela Scariot
João Cesar Zielak
Publikationsdatum: 12.12.2017
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2018
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-017-1490-3

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Intermittent administration of PTH induces the expression of osteocalcin and BMP-2 on choroid plexus cells associated with suppression of sclerostin, TGF-β1, and Na⁺K⁺ATPase

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