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Cancer Immunology, Immunotherapy

Erschienen in:

09.07.2021 | Review

Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity

verfasst von: Kirsten M. Baecher, Mandy L. Ford

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 12/2021

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Abstract

Fc receptors (FcRs) and the microbiome are both known to have an effect on the development and progression of cancers. Checkpoint inhibitors are a novel class of therapeutics which are used to combat cancer and are integrally linked to both FcRs and the microbiome. The use of checkpoint inhibitors has grown exponentially over the past decade, although many host factors affect both the efficacy and the safety of these therapeutics. Some of these host factors, including the microbiome and the expression of FcRs, are currently being investigated. Here we discuss the current understanding of FcRs (particularly the inhibitory FcγRIIB) and the microbiome in context of T cell immunity, inflammation, cancer, and checkpoint inhibition.

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Titel: Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity
verfasst von: Kirsten M. Baecher
Mandy L. Ford
Publikationsdatum: 09.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 12/2021
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-021-03004-4

Springer Medizin

Intersection of FcγRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity

Abstract

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Springer Medizin

Abstract

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