nach oben

Current HIV/AIDS Reports

Erschienen in:

14.06.2019 | Implementation Science (E Geng, Section Editor)

Interventions to Improve Linkage to HIV Care in the Era of “Treat All” in Sub-Saharan Africa: a Systematic Review

verfasst von: Nicole Kelly, Werner Maokola, Omobola Mudasiru, Sandra I. McCoy

Erschienen in: Current HIV/AIDS Reports | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of the Review

In 2015, antiretroviral therapy (ART) was recommended for all people living with HIV (PLHIV) regardless of CD4 count (“Treat All”). To better understand how to improve linkage to care under these new guidelines, we conducted a systematic review of studies evaluating linkage interventions in Sub-Saharan Africa under Treat All.

Recent Findings

We identified 14 eligible articles and qualitatively analyzed the effectiveness of the interventions. Increases in linkage were reported by supply-side and counseling interventions. Mobile testing and economic incentives did not increase linkage.

Summary

Given the lag time between adoption and implementation, only two of the studies were conducted in a Treat All setting. None of the interventions specifically focused on re-linking PLHIV who had disengaged from care. Future studies must design interventions that target not only newly diagnosed or treatment naïve PLHIV, but should explicitly focus on PLHIV who have disengaged from care.

Nur mit Berechtigung zugänglich

Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. WHO: World Health Organization; 2015.

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505. https://doi.org/10.1056/NEJMoa1105243.CrossRefPubMedPubMedCentral

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med. 2016;375(9):830–9. https://doi.org/10.1056/NEJMoa1600693.CrossRefPubMedPubMedCentral

Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, van Lunzen J, et al. Sexual activity without condoms and risk of HIV transmission in Serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA. 2016;316(2):171–81. https://doi.org/10.1001/jama.2016.5148.CrossRefPubMed

• Miles to Go…. In: UNAIDS. Miles to go: closing gaps breaking barriers righting injustices. UNAIDS; 2018. https://doi.org/10.1111/j.1600-6143.2011.03542.x. This report highlights global and regional gaps in linkage to HIV care by providing current estimates of PLHIV who are not accessing ART despite all PLHIV being eligible under Treat All.

Collaborators GH. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the global burden of disease study 2015. Lancet HIV. 2016;3(8):e361–e87. https://doi.org/10.1016/S2352-3018(16)30087-X.CrossRef

Kharsany AB, Karim QA. HIV infection and AIDS in sub-Saharan Africa: current status, challenges and opportunities. Open AIDS J. 2016;10:34–48. https://doi.org/10.2174/1874613601610010034.CrossRefPubMedPubMedCentral

Fox MP, Rosen S. A new cascade of HIV care for the era of "treat all". PLoS Med. 2017;14(4):e1002268. https://doi.org/10.1371/journal.pmed.1002268.CrossRefPubMedPubMedCentral

Babalola S, Van Lith LM, Mallalieu EC, Packman ZR, Myers E, Ahanda KS, et al. A framework for health communication across the HIV treatment continuum. J Acquir Immune Defic Syndr. 2017;74(Suppl 1):S5–S14. https://doi.org/10.1097/QAI.0000000000001206.CrossRefPubMed

10.

McNairy ML, Lamb MR, Gachuhi AB, Nuwagaba-Biribonwoha H, Burke S, Mazibuko S, et al. Effectiveness of a combination strategy for linkage and retention in adult HIV care in Swaziland: the Link4Health cluster randomized trial. PLoS Med. 2017;14(11):e1002420. https://doi.org/10.1371/journal.pmed.1002420.CrossRefPubMedPubMedCentral

11.

Maughan-Brown B, Smith P, Kuo C, Harrison A, Lurie MN, Bekker LG, et al. A conditional economic incentive fails to improve linkage to care and antiretroviral therapy initiation among HIV-positive adults in Cape Town, South Africa. AIDS Patient Care STDs. 2018;32(2):70–8. https://doi.org/10.1089/apc.2017.0238.CrossRefPubMedPubMedCentral

12.

Ayieko J, Petersen ML, van Rie A, Wafula E, Opudo W, Clark TD, et al. Effect of a patient-centered phone call by a clinical officer at time of HIV testing on linkage to care in rural Kenya. Open Forum Infect Dis. 2018;5(6):ofy126. https://doi.org/10.1093/ofid/ofy126.CrossRefPubMedPubMedCentral

13.

Labhardt ND, Ringera I, Lejone TI, Klimkait T, Muhairwe J, Amstutz A, et al. Effect of offering same-day ART vs usual health facility referral during home-based HIV testing on linkage to care and viral suppression among adults with HIV in Lesotho: the CASCADE randomized clinical trial. JAMA. 2018;319(11):1103–12. https://doi.org/10.1001/jama.2018.1818.CrossRefPubMedPubMedCentral

14.

Elul B, Lamb MR, Lahuerta M, Abacassamo F, Ahoua L, Kujawski SA, et al. A combination intervention strategy to improve linkage to and retention in HIV care following diagnosis in Mozambique: a cluster-randomized study. PLoS Med. 2017;14(11):e1002433. https://doi.org/10.1371/journal.pmed.1002433.CrossRefPubMedPubMedCentral

15.

Cherutich P, Golden MR, Wamuti B, Richardson BA, Asbjornsdottir KH, Otieno FA, et al. Assisted partner services for HIV in Kenya: a cluster randomised controlled trial. Lancet HIV. 2017;4(2):e74–82. https://doi.org/10.1016/S2352-3018(16)30214-4.CrossRefPubMed

16.

Ruzagira E, Grosskurth H, Kamali A, Baisley K. Brief counselling after home-based HIV counselling and testing strongly increases linkage to care: a cluster-randomized trial in Uganda. J Int AIDS Soc. 2017;20(2):e25014. https://doi.org/10.1002/jia2.25014.CrossRefPubMedCentral

17.

Asiimwe S, Ross JM, Arinaitwe A, Tumusiime O, Turyamureeba B, Roberts DA, et al. Expanding HIV testing and linkage to care in southwestern Uganda with community health extension workers. J Int AIDS Soc. 2017;20(Suppl 4):21633. https://doi.org/10.7448/IAS.20.5.21633.CrossRefPubMedPubMedCentral

18.

Sanga ES, Lerebo W, Mushi AK, Clowes P, Olomi W, Maboko L, et al. Linkage into care among newly diagnosed HIV-positive individuals tested through outreach and facility-based HIV testing models in Mbeya, Tanzania: a prospective mixed-method cohort study. BMJ Open. 2017;7(4):e013733. https://doi.org/10.1136/bmjopen-2016-013733.CrossRefPubMedPubMedCentral

19.

Hoffmann CJ, Mabuto T, Ginindza S, Fielding KL, Kubeka G, Dowdy DW, et al. Strategies to accelerate HIV care and antiretroviral therapy initiation after HIV diagnosis: a randomized trial. J Acquir Immune Defic Syndr. 2017;75(5):540–7. https://doi.org/10.1097/QAI.0000000000001428.CrossRefPubMed

20.

Hewett PC, Nalubamba M, Bozzani F, Digitale J, Vu L, Yam E, et al. Randomized evaluation and cost-effectiveness of HIV and sexual and reproductive health service referral and linkage models in Zambia. BMC Public Health. 2016;16:785. https://doi.org/10.1186/s12889-016-3450-x.CrossRefPubMedPubMedCentral

21.

Barnabas RV, van Rooyen H, Tumwesigye E, Brantley J, Baeten JM, van Heerden A, et al. Uptake of antiretroviral therapy and male circumcision after community-based HIV testing and strategies for linkage to care versus standard clinic referral: a multisite, open-label, randomised controlled trial in South Africa and Uganda. Lancet HIV. 2016;3(5):e212–20. https://doi.org/10.1016/S2352-3018(16)00020-5.CrossRefPubMedPubMedCentral

22.

Desai MA, Okal DO, Rose CE, Ndivo R, Oyaro B, Otieno FO, et al. Effect of point-of-care CD4 cell count results on linkage to care and antiretroviral initiation during a home-based HIV testing campaign: a non-blinded, cluster-randomised trial. Lancet HIV. 2017;4(9):e393–401. https://doi.org/10.1016/S2352-3018(17)30091-7.CrossRefPubMed

23.

Amanyire G, Semitala FC, Namusobya J, Katuramu R, Kampiire L, Wallenta J, et al. Effects of a multicomponent intervention to streamline initiation of antiretroviral therapy in Africa: a stepped-wedge cluster-randomised trial. Lancet HIV. 2016;3(11):e539–e48. https://doi.org/10.1016/S2352-3018(16)30090-X.CrossRefPubMedPubMedCentral

24.

Rosen S, Fox MP. Retention in HIV care between testing and treatment in sub-Saharan Africa: a systematic review. PLoS Med. 2011;8(7):e1001056. https://doi.org/10.1371/journal.pmed.1001056.CrossRefPubMedPubMedCentral

25.

Govindasamy D, Meghij J, Kebede Negussi E, Clare Baggaley R, Ford N, Kranzer K. Interventions to improve or facilitate linkage to or retention in pre-ART (HIV) care and initiation of ART in low- and middle-income settings--a systematic review. J Int AIDS Soc. 2014;17:19032. https://doi.org/10.7448/IAS.17.1.19032.CrossRefPubMedPubMedCentral

26.

Ruzagira E, Baisley K, Kamali A, Biraro S, Grosskurth H. Working group on linkage to HIVC. Linkage to HIV care after home-based HIV counselling and testing in sub-Saharan Africa: a systematic review. Tropical Med Int Health. 2017;22(7):807–21. https://doi.org/10.1111/tmi.12888.CrossRef

27.

Sharma M, Ying R, Tarr G, Barnabas R. Systematic review and meta-analysis of community and facility-based HIV testing to address linkage to care gaps in sub-Saharan Africa. Nature. 2015;528(7580):S77–85. https://doi.org/10.1038/nature16044.CrossRefPubMedPubMedCentral

28.

Proctor EK, Powell BJ, McMillen JC. Implementation strategies: recommendations for specifying and reporting. Implement Sci. 2013;8:139. https://doi.org/10.1186/1748-5908-8-139.CrossRefPubMedPubMedCentral

29.

Eccles MP, Mittman BS. Welcome to implementation science. ImplementationSci. 2006;1(1). https://doi.org/10.1186/1748-5908-1-1.

30.

Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Admin Pol Ment Health. 2010;38(2):65–76.CrossRef

31.

The World Bank. Sub-Saharan Africa. https://data.worldbank.org/region/ sub-saharanafrica. 2018.

32.

Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org.

33.

Use of antiretroviral drugs for treating pregnant women and preventing HIV infection in infants. WHO: World Health Organization; 2012.

34.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.CrossRefPubMedPubMedCentral

35.

The Republic of Uganda Ministry of Health. Consolidated guidelines for prevention and treatment of HIV in Uganda.; 2016.

36.

The Zambian Ministry of Health. Zambia consolidated guidelines for treatment and prevention of HIV infection.; 2014.

37.

Ministry of Health; National AIDS and STI Control Program (NASCOP). Guidelines on use of antiretroviral drugs for treating and preventing HIV infection: a rapid advice; 2014.

38.

National AIDS/STI Control Program (NASCOP). Guidelines for antiretroviral therapy in Kenya. 4th Edition. Nairobi, Kenya; 2011.

39.

• Yotebieng M, Brazier E, Addison D, Kimmel AD, Cornell M, Keiser O, et al. Research priorities to inform "treat all" policy implementation for people living with HIV in sub-Saharan Africa: a consensus statement from the international epidemiology databases to evaluate AIDS (IeDEA). J Int AIDS Soc. 2019;22(1):e25218. https://doi.org/10.1002/jia2.25218 This paper specifically notes that improving linkage to HIV care is a critical research priority for Sub-Saharan Africa in the era of Treat All. CrossRefPubMedPubMedCentral

40.

World Health Organization. WHO HIV policy adoption and implementation status in countries. WHO; 2018.

41.

Fox MP, Rosen S. Retention of adult patients on antiretroviral therapy in low- and middle-income countries: systematic review and meta-analysis 2008-2013. J Acquir Immune Defic Syndr. 2015;69(1):98–108. https://doi.org/10.1097/QAI.0000000000000553.CrossRefPubMedPubMedCentral

42.

Gentilini U. Revisiting the ‘cash versus food’ debate: new evidence for an old puzzle. World Bank Res Obs. 2016;31:135–67.

43.

Thurow L. Cash versus in-kind transfers. Am Econ Rev. 1974;64(2):190–5.

44.

Knol MJ, Le Cessie S, Algra A, Vandenbroucke JP, Groenwold RH. Overestimation of risk ratios by odds ratios in trials and cohort studies: alternatives to logistic regression. CMAJ. 2012;184(8):895–9. https://doi.org/10.1503/cmaj.101715.CrossRefPubMedPubMedCentral

Titel: Interventions to Improve Linkage to HIV Care in the Era of “Treat All” in Sub-Saharan Africa: a Systematic Review
verfasst von: Nicole Kelly
Werner Maokola
Omobola Mudasiru
Sandra I. McCoy
Publikationsdatum: 14.06.2019
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 4/2019
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-019-00451-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren.

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose of the Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2019

Mobility and its Effects on HIV Acquisition and Treatment Engagement: Recent Theoretical and Empirical Advances

A Review of Differentiated Service Delivery for HIV Treatment: Effectiveness, Mechanisms, Targeting, and Scale

Obstructive Lung Disease in HIV—Phenotypes and Pathogenesis

Implementation Strategies to Increase PrEP Uptake in the South

Design Considerations for Implementing eHealth Behavioral Interventions for HIV Prevention in Evolving Sociotechnical Landscapes