nach oben

Journal of Cardiovascular Translational Research

Erschienen in:

08.05.2020 | Original Article

Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts

verfasst von: Ajay Godwin Potnuri, Lingesh Allakonda, Sherin Saheera

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 1/2021

Einloggen, um Zugang zu erhalten

Abstract

Despite the involvement of ɑ1adrenergic (ɑ1AR) and Histamine 2 receptors (H2R) in cardiac hypertrophy (CH), their relationship is yet to be studied. Our study investigated interrelationship between them using in vitro CH model. H9c2 cardiomyoblasts were exposed to phenylephrine (ɑ1AR agonist-50 μM) in the presence, the absence of famotidine (H2R antagonist-10 μM) and BAY 11-7082 (NF-kB inhibitor-10 μM). The impact of ɑ1AR stimulation on H2R expression and oxidative stress was assessed. Hypertrophic indices were assessed from activities of enzymatic mediators of cardiac hypertrophy, total protein content, BNP levels and cell volume. Additionally, the inverse agonistic property of famotidine and NFkB activity was also studied. ɑ1AR-induced H2R expression, oxidative stress and hypertrophic indices were significantly abolished by famotidine and pharmacological inhibitor of NFkB. Increase in constitutive activity of H2R was noticed correlating with increased receptor population. These results suggest involvement of NFkB-mediated upregulation of H2R in ɑ1AR-mediated CH.

Nur mit Berechtigung zugänglich

Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J. (2009). The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. Journal of the American College of Cardiology, 54(19), 1747–1762. https://doi.org/10.1016/j.jacc.2009.05.015.CrossRefPubMed

Porter, K. E., & Turner, N. A. (2009). Cardiac fibroblasts: At the heart of myocardial remodeling. Pharmacology & Therapeutics, 123(2), 255–278. https://doi.org/10.1016/j.pharmthera.2009.05.002.CrossRef

Lim, H. W., Windt, L. J. D., Steinberg, L., Taigen, T., Witt, S. A., Kimball, T. R., & Molkentin, J. D. (2000). Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation, 101(20), 2431–2437. https://doi.org/10.1161/01.CIR.101.20.2431.CrossRefPubMed

Cooling, M., Hunter, P., & Crampin, E. J. (2007). Modeling hypertrophic IP3 transients in the cardiac Myocyte. Biophysical Journal, 93(10), 3421–3433. https://doi.org/10.1529/biophysj.107.110031.CrossRefPubMedPubMedCentral

Sakata, Y., Hoit, B. D., Liggett, S. B., Walsh, R. A., & Dorn, G. W. (1998). Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. Circulation, 97(15), 1488–1495.CrossRef

Pönicke, K., Vogelsang, M., Heinroth, M., Becker, K., Zolk, O., Böhm, M., et al. (1998). Endothelin receptors in the failing and nonfailing human heart. Circulation, 97(8), 744–751.CrossRef

Clark, W. A., Rudnick, S. J., Andersen, L. C., & LaPres, J. J. (1994). Myosin heavy chain synthesis is independently regulated in hypertrophy and atrophy of isolated adult cardiac myocytes. The Journal of Biological Chemistry, 269(41), 25562–25569.CrossRef

Clark, W. A., Rudnick, S. J., LaPres, J. J., Andersen, L. C., & LaPointe, M. C. (1993). Regulation of hypertrophy and atrophy in cultured adult heart cells. Circulation Research, 73(6), 1163–1176.CrossRef

Ikeda, U., Tsuruya, Y., & Yaginuma, T. (1991). Alpha 1-adrenergic stimulation is coupled to cardiac myocyte hypertrophy. The American Journal of Physiology, 260(3 Pt 2), H953–H956.PubMed

10.

Fuller, S. J., Gaitanaki, C. J., & Sugden, P. H. (1990). Effects of catecholamines on protein synthesis in cardiac myocytes and perfused hearts isolated from adult rats. Stimulation of translation is mediated through the alpha 1-adrenoceptor. The Biochemical Journal, 266(3), 727–736.CrossRef

11.

Knowlton, K. U., Baracchini, E., Ross, R. S., Harris, A. N., Henderson, S. A., Evans, S. M., et al. (1991). Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. The Journal of Biological Chemistry, 266(12), 7759–7768.CrossRef

12.

Bishopric, N. H., Simpson, P. C., & Ordahl, C. P. (1987). Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes. The Journal of Clinical Investigation, 80(4), 1194–1199. https://doi.org/10.1172/JCI113179.CrossRefPubMedPubMedCentral

13.

Kariya, K., Farrance, I. K., & Simpson, P. C. (1993). Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. The Journal of Biological Chemistry, 268(35), 26658–26662.CrossRef

14.

Long, C. S., Ordahl, C. P., & Simpson, P. C. (1989). Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. The Journal of Clinical Investigation, 83(3), 1078–1082. https://doi.org/10.1172/JCI113951.CrossRefPubMedPubMedCentral

15.

Seddon, M., Looi, Y. H., & Shah, A. M. (2007). Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart, 93(8), 903–907. https://doi.org/10.1136/hrt.2005.068270.CrossRefPubMed

16.

Gaitanaki, C., Konstantina, S., Chrysa, S., & Beis, I. (2003). Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart. The Journal of Experimental Biology, 206(Pt 16), 2759–2769.CrossRef

17.

Heineke, J., & Molkentin, J. D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature reviews. Molecular and Cellular Biology, 7(8), 589–600. https://doi.org/10.1038/nrm1983.CrossRef

18.

He, H., Liu, X., Lv, L., Liang, H., Leng, B., Zhao, D., et al. (2014). Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress. Cell Death & Disease, 5, e997. https://doi.org/10.1038/cddis.2013.533.CrossRef

19.

Takimoto, E., & Kass, D. A. (2007). Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension, 49(2), 241–248. https://doi.org/10.1161/01.HYP.0000254415.31362.a7.CrossRefPubMed

20.

Xu, Q., Dalic, A., Fang, L., Kiriazis, H., Ritchie, R., Sim, K., et al. (2011). Myocardial oxidative stress contributes to transgenic β2-adrenoceptor activation-induced cardiomyopathy and heart failure. British Journal of Pharmacology, 162(5), 1012–1028. https://doi.org/10.1111/j.1476-5381.2010.01043.x.CrossRefPubMedPubMedCentral

21.

Di Lisa, F., Kaludercic, N., & Paolocci, N. (2011). β₂–Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another “radical” road to heart failure? British Journal of Pharmacology, 162(5), 1009–1011. https://doi.org/10.1111/j.1476-5381.2010.01130.x.CrossRefPubMedPubMedCentral

22.

Haenen, G. R., Veerman, M., & Bast, A. (1990). Reduction of beta-adrenoceptor function by oxidative stress in the heart. Free Radical Biology & Medicine, 9(4), 279–288.CrossRef

23.

Hara, M., Ono, K., Hwang, M.-W., Iwasaki, A., Okada, M., Nakatani, K., et al. (2002). Evidence for a role of mast cells in the evolution to congestive heart failure. The Journal of Experimental Medicine, 195(3), 375–381.CrossRef

24.

Dvorak, A. M. (1986). Mast-cell degranulation in human hearts. The New England Journal of Medicine, 315(15), 969–970.PubMed

25.

Luo, T., Chen, B., Zhao, Z., He, N., Zeng, Z., Wu, B., et al. (2013). Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function. Basic Research in Cardiology, 108(3), 342. https://doi.org/10.1007/s00395-013-0342-4.CrossRefPubMed

26.

Zeng, Z., Shen, L., Li, X., Luo, T., Wei, X., Zhang, J., et al. (2014). Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis. Clinical Science (London, England : 1979), 127(7), 435–448. https://doi.org/10.1042/CS20130716.CrossRef

27.

Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2016). Targeting histamine-2 receptor for prevention of cardiac remodelling in chronic pressure overload. International Journal of Cardiology, 202, 831–833. https://doi.org/10.1016/j.ijcard.2015.10.040.CrossRefPubMed

28.

Takahama, H., Asanuma, H., Sanada, S., Fujita, M., Sasaki, H., Wakeno, M., et al. (2010). A histamine H2 receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. Basic Research in Cardiology, 105(6), 787–794. https://doi.org/10.1007/s00395-010-0119-y.CrossRefPubMed

29.

Ahmadi, A., Ebrahimzadeh, M. A., Ahmad-Ashrafi, S., Karami, M., Mahdavi, M. R., & Saravi, S. S. S. (2011). Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. Fundamental & Clinical Pharmacology, 25(1), 72–79. https://doi.org/10.1111/j.1472-8206.2009.00810.x.CrossRef

30.

Kesiova, M., Alexandrova, A., Yordanova, N., Kirkova, M., & Todorov, S. (2006). Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacological reports: PR, 58(2), 221–228.PubMed

31.

Herman, F. F., Goldberg, B. J., Lad, P. M., Neidzin, H., Kaplan, M., & Easton, J. G. (1990). Effects of histamine on alpha adrenergic receptor expression on the lymphocytes of normal and asthmatic subjects. Annals of Allergy, 65(1), 32–36.PubMed

32.

Rius, R. A., Mollner, S., Pfeuffer, T., & Peng Loh, Y. (1994). Developmental changes in Gs and golf proteins and adenylyl cyclases in mouse brain membranes. Brain Research, 643(1–2), 50–58. https://doi.org/10.1016/0006-8993(94)90007-8.CrossRefPubMed

33.

Fraga, C. G., Leibovitz, B. E., & Tappel, A. L. (1988). Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radical Biology and Medicine, 4(3), 155–161. https://doi.org/10.1016/0891-5849(88)90023-8.CrossRefPubMed

34.

Weydert, C. J., & Cullen, J. J. (2010). Measurement of superoxide dismutase, catalase, and glutathione peroxidase in cultured cells and tissue. Nature Protocols, 5(1), 51–66. https://doi.org/10.1038/nprot.2009.197.CrossRefPubMed

35.

Li, R., Jen, N., Yu, F., & Hsiai, T. K. (2011). Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Current protocols in cytometry/editorial board, J. Paul Robinson, managing editor ... [et al.], CHAPTER, Unit9.37. doi:https://doi.org/10.1002/0471142956.cy0937s58.

36.

Eruslanov, E., & Kusmartsev, S. (2010). Identification of ROS using oxidized DCFDA and flow-cytometry. Methods in Molecular Biology (Clifton, N.J.), 594, 57–72. https://doi.org/10.1007/978-1-60761-411-1_4.CrossRef

37.

Knowles, J. W., Esposito, G., Mao, L., Hagaman, J. R., Fox, J. E., Smithies, O., et al. (2001). Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A–deficient mice. Journal of Clinical Investigation, 107(8), 975–984.CrossRef

38.

Nadruz, W. (2015). Myocardial remodeling in hypertension. Journal of Human Hypertension, 29(1), 1–6. https://doi.org/10.1038/jhh.2014.36.CrossRefPubMed

39.

Aceros, H., Farah, G., Cobos-Puc, L., Stabile, A., Noiseux, N., & Mukaddam-Daher, S. (2011). Moxonidine improves cardiac structure and performance in SHR through inhibition of cytokines, p38 MAPK and Akt. British Journal of Pharmacology, 164(3), 946–957. https://doi.org/10.1111/j.1476-5381.2011.01355.x.CrossRefPubMedPubMedCentral

40.

Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2018). Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 41(12), 1023–1035. https://doi.org/10.1038/s41440-018-0109-2.CrossRef

41.

Kim, J., Ogai, A., Nakatani, S., Hashimura, K., Kanzaki, H., Komamura, K., et al. (2006). Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies. Journal of the American College of Cardiology, 48(7), 1378–1384. https://doi.org/10.1016/j.jacc.2006.05.069.CrossRefPubMed

42.

Khilnani, G., & Khilnani, A. K. (2011). Inverse agonism and its therapeutic significance. Indian Journal of Pharmacology, 43(5), 492–501. https://doi.org/10.4103/0253-7613.84947.CrossRefPubMedPubMedCentral

43.

Monczor, F. (2006). Mechanisms of inverse agonism at histamine H(2) receptors - potential benefits and concerns. Inflammopharmacology, 14(1–2), 89–96. https://doi.org/10.1007/s10787-006-1516-6.CrossRefPubMed

44.

Baker, J. G., Hall, I. P., & Hill, S. J. (2003). Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling. Molecular Pharmacology, 64(6), 1357–1369. https://doi.org/10.1124/mol.64.6.1357.CrossRefPubMed

45.

Lai, L., Yan, L., Gao, S., Hu, C.-L., Ge, H., Davidow, A., et al. (2013). Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1/FoxO3a pathway. Circulation, CIRCULATIONAHA, 113, 001212. https://doi.org/10.1161/CIRCULATIONAHA.112.001212.CrossRef

46.

Matsushima, S., Ide, T., Yamato, M., Matsusaka, H., Hattori, F., Ikeuchi, M., et al. (2006). Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice. Circulation, 113(14), 1779–1786. https://doi.org/10.1161/CIRCULATIONAHA.105.582239.CrossRefPubMed

Titel: Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts
verfasst von: Ajay Godwin Potnuri
Lingesh Allakonda
Sherin Saheera
Publikationsdatum: 08.05.2020
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 1/2021
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-020-09967-6

Neu im Fachgebiet Kardiologie

25.04.2024 | Hypotonie | Nachrichten

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts

Abstract

Neu im Fachgebiet Kardiologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adipositas-Medikament auch gegen Schlafapnoe wirksam

Komplette Revaskularisation bei Infarkt: Neue Studie setzt ein Fragezeichen

Update Kardiologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2021

Facilitation Through Aggrastat or Cangrelor Bolus and Infusion Over PrasugreL: a MUlticenter Randomized Open-label Trial in PatientS with ST-elevation Myocardial InFarction Referred for PrimAry PercutaneouS InTERvention (FABOLUS FASTER) Trial: Design and Rationale

Current Perspectives on Inflammation in Cardiovascular Disease; from Biomarker to Therapy

The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

Role of Heat Shock Protein 27 in Modulating Atherosclerotic Inflammation

Diagnostic and Prognostic Value of Coronary Computed Tomography Angiography in Patients with Severe Calcification

Requirements for Proper Immunosuppressive Regimens to Limit Translational Failure of Cardiac Cell Therapy in Preclinical Large Animal Models

Neu im Fachgebiet Kardiologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adipositas-Medikament auch gegen Schlafapnoe wirksam

Komplette Revaskularisation bei Infarkt: Neue Studie setzt ein Fragezeichen

Update Kardiologie