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22.09.2017 | Nephrology - Review

Iron in kidney and heart failure: from theory to practice

verfasst von: Aslihan Yerlikaya, Mustafa C. Bulbul, Baris Afsar, Tuncay Dagel, Gamze Aslan, Luminita Voroneanu, Dimitire Siriopol, Adrian Covic, Mehmet Kanbay

Erschienen in: International Urology and Nephrology | Ausgabe 3/2018

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Abstract

There is evidence that serum iron levels, regardless of the presence of anemia, directly impact outcomes in congestive heart failure (CHF) including quality of life, hospitalization rate and overall survival. Despite modern medical treatments, the prognosis of CHF remains grim. Ironically, simple iron replenishment may serve as a powerful tool in the armamentarium. This review will start from fundamental concepts of iron in oxygen delivery and analyze evidence-based outcomes in CHF iron-directed therapeutic trials. Imaging rationale that dovetails with this pathophysiology will also be detailed in a clinician-directed fashion.

Bui AL, Horwich TB, Fonarow GC (2011) Epidemiology and risk profile of heart failure. Nat Rev Cardiol 8(1):30–41CrossRefPubMed

Cook C, Cole G, Asaria P, Jabbour R, Francis DP (2014) The annual global economic burden of heart failure. Int J Cardiol 171(3):368–376CrossRefPubMed

Fitzsimons S, Doughty RN (2015) Iron deficiency in patients with heart failure. Eur Heart J Cardiovasc Pharmacother 1(1):58–64CrossRefPubMed

Anker SD, von Haehling S (2004) Inflammatory mediators in chronic heart failure: an overview. Heart 90(4):464–470CrossRefPubMedPubMedCentral

Dickstein K, Authors/Task Force M, Cohen-Solal A, Filippatos G, McMurray JJV, Ponikowski P et al (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008‡. Eur J Heart Fail 10(10):933–989CrossRefPubMed

Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S (1994) Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J 72(6):561–566CrossRefPubMedPubMedCentral

Tsutamoto T, Hisanaga T, Wada A, Maeda K, Ohnishi M, Fukai D et al (1998) Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J Am Coll Cardiol 31(2):391–398CrossRefPubMed

Niebauer J, Volk H-D, Kemp M, Dominguez M, Schumann RR, Rauchhaus M et al (1999) Endotoxin and immune activation in chronic heart failure: a prospective cohort study. Lancet 353(9167):1838–1842CrossRefPubMed

Grabellus F, Levkau B, Sokoll A, Welp H, Schmid C, Deng MC et al (2002) Reversible activation of nuclear factor-κB in human end-stage heart failure after left ventricular mechanical support. Cardiovasc Res 53(1):124–130CrossRefPubMed

10.

Mann DL (2002) Inflammatory mediators and the failing heart. Circ Res 91(11):988–998CrossRefPubMed

11.

Drexler H, Hornig B (1999) Endothelial dysfunction in human disease. J Mol Cell Cardiol 31(1):51–60CrossRefPubMed

12.

Attanasio P, Katz SD, Anker SD (2010) Treatment with iron of patients with heart failure with and without anemia. Heart Fail Clin 6(3):305–312CrossRefPubMed

13.

Jankowska EA, Von Haehling S, Anker SD, Macdougall IC, Ponikowski P (2013) Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J 34(11):816–829CrossRefPubMed

14.

Silverberg D, Iaina A, Wexler D, Schwartz D (2011) Iron repletion in heart failure patients. Hypertension 57(3):381–382CrossRefPubMed

15.

Ponka P (1999) Cellular iron metabolism. Kidney Int 55:S2–S11CrossRef

16.

Silverberg DS, Iaina A, Schwartz D, Wexler D (2011) Intravenous iron in heart failure: beyond targeting anemia. Curr Heart Fail Rep 8(1):14–21CrossRefPubMed

17.

Okonko DO, Mandal AK, Missouris CG, Poole-Wilson PA (2011) Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J Am Coll Cardiol 58(12):1241–1251CrossRefPubMed

18.

Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B et al (2010) Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur Heart J 31(15):1872–1880CrossRefPubMed

19.

Hughes C, Woodside J, McGartland C, Roberts M, Nicholls D, McKeown P (2012) Nutritional intake and oxidative stress in chronic heart failure. Nutr Metabol Cardiovasc Dis 22(4):376–382CrossRef

20.

Lourenço BH, Vieira LP, Macedo A, Nakasato M, Marucci MDFN, Bocchi EA (2009) Nutritional status and adequacy of energy and nutrient intakes among heart failure patients. Arq Bras Cardiol 93(5):541–548CrossRefPubMed

21.

Dong F, Zhang X, Culver B, Chew HG, Kelley RO, Ren J (2005) Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Clin Sci 109(3):277–286CrossRefPubMed

22.

Stugiewicz M, Tkaczyszyn M, Kasztura M, Banasiak W, Ponikowski P, Jankowska EA (2016) The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications. Eur J Heart Fail 18(7):762–773CrossRefPubMed

23.

Goldstein D, Felzen B, Youdim M, Lotan R, Binah O (1996) Experimental iron deficiency in rats: mechanical and electrophysiological alterations in the cardiac muscle. Clin Sci 91(2):233–239CrossRefPubMed

24.

Zhu YI, Haas JD (1998) Altered metabolic response of iron-depleted nonanemic women during a 15-km time trial. J Appl Physiol 84(5):1768–1775CrossRefPubMed

25.

Haas JD, Brownlie T (2001) Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 131(2):676S–690SCrossRefPubMed

26.

Finch C, Miller L, Inamdar A, Person R, Seiler K, Mackler B (1976) Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. J Clin Investig 58(2):447CrossRefPubMedPubMedCentral

27.

Carson JL, Adamson JW (2010) Iron deficiency and heart disease: ironclad evidence? ASH Educ Program Book 2010(1):348–350

28.

Maeder MT, Khammy O, dos Remedios C, Kaye DM (2011) Myocardial and systemic iron depletion in heart failure: implications for anemia accompanying heart failure. J Am Coll Cardiol 58(5):474–480CrossRefPubMed

29.

McMurray J, Ponikowski P (2011) Heart failure. J Am Coll Cardiol 58(5):481–482CrossRefPubMed

30.

Varma A, Appleton D, Nusca A, Lipinski M, Goudreau E, Cowley M et al (2010) Iron deficiency anemia and cardiac mortality in patients with left ventricular systolic dysfunction undergoing coronary stenting. Minerva Cardioangiol 58(1):1–10PubMed

31.

Murphy C, Fitzsimons E, Jardine A, Sattar N, Mcmurray J (2007) 103 Routine assessment of iron status in all patients with heart failure may identify those at risk of developing anaemia. Eur J Heart Fail 6(S1):24

32.

Rangel I, Gonçalves A, De Sousa C, Leite S, Campelo M, Martins E et al (2014) Iron deficiency status irrespective of anemia: a predictor of unfavorable outcome in chronic heart failure patients. Cardiology 128(4):320–326CrossRefPubMed

33.

de Silva R, Rigby AS, Witte KK, Nikitin NP, Tin L, Goode K et al (2006) Anemia, renal dysfunction, and their interaction in patients with chronic heart failure. Am Cardiol 98(3):391–398CrossRef

34.

Nanas JN, Matsouka C, Karageorgopoulos D, Leonti A, Tsolakis E, Drakos SG et al (2006) Etiology of anemia in patients with advanced heart failure. J Am Coll Cardiol 48(12):2485–2489CrossRefPubMed

35.

Klip IT, Comin-Colet J, Voors AA, Ponikowski P, Enjuanes C, Banasiak W et al (2013) Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 165(4):575–582.e3CrossRefPubMed

36.

Yeo TJ, Yeo PSD, Ching-Chiew Wong R, Ong HY, Leong KTG, Jaufeerally F et al (2014) Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis. Eur J Heart Fail 16(10):1125–1132CrossRefPubMed

37.

Cohen-Solal A, Damy T, Hanon O, Terbah M, Laperche T, Kerebel S et al (2014) High prevalence of iron deficiency in patients admitted for acute decompensated heart failure: a French study (Cardiofer). J Am Coll Cardiol 12(63):A779CrossRef

38.

Toblli JE, Lombraña A, Duarte P, Di Gennaro F (2007) Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. J Am Coll Cardiol 50(17):1657–1665CrossRefPubMed

39.

Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H et al (2009) Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med 361(25):2436–2448CrossRefPubMed

40.

Filippatos G, Farmakis D, Colet JC, Dickstein K, Lüscher TF, Willenheimer R et al (2013) Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. Eur J Heart Fail 15(11):1267–1276CrossRefPubMedPubMedCentral

41.

Ponikowski P, Van Veldhuisen DJ, Comin-Colet J, Ertl G, Komajda M, Mareev V et al (2015) Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J 36(11):657–668CrossRefPubMed

42.

Usmanov RI, Zueva EB, Silverberg DS, Shaked M (2008) Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. J Nephrol 21(2):236–242PubMed

43.

Gaber R, Kotb NA, Ghazy M, Nagy HM, Salama M, Elhendy A (2012) Tissue Doppler and strain rate imaging detect improvement of myocardial function in iron deficient patients with congestive heart failure after iron replacement therapy. Echocardiography. 29(1):13–18CrossRefPubMed

44.

Alexandrakis MG, Tsirakis G (2012) Anemia in heart failure patients. ISRN Hematol 2012:246915CrossRefPubMedPubMedCentral

45.

Palazzuoli A, Ruocco G, Pellegrini M, De Gori C, Del Castillo G, Giordano N et al (2014) The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions. Ther Clin Risk Manag 10:641–650CrossRefPubMedPubMedCentral

46.

Ghali JK, Anand IS, Abraham WT, Fonarow GC, Greenberg B, Krum H et al (2008) Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia. Circulation 117(4):526–535CrossRefPubMed

47.

Kaldara-Papatheodorou EE, Terrovitis JV, Nanas JN (2010) Anemia in heart failure. Polskie Archiwum Medycyny Wewnętrznej 120(9):354–360PubMed

48.

McCullough PA (2011) Micronutrients and cardiorenal disease: insights into novel assessments and treatment. Blood Purif 31(1–3):177–185CrossRefPubMed

49.

Silverberg DS (2011) The role of erythropoiesis stimulating agents and intravenous (IV) iron in the cardio renal anemia syndrome. Heart Fail Rev 16(6):609–614CrossRefPubMed

50.

Silverberg DS, Wexler D, Iaina A, Schwartz D (2011) Correction of iron deficiency in the cardiorenal syndrome. Int J Nephrol 2011:365301CrossRefPubMedPubMedCentral

51.

Palazzuoli A, Antonelli G, Nuti R (2011) Anemia in cardio-renal syndrome: clinical impact and pathophysiologic mechanisms. Heart Fail Rev 16(6):603–607CrossRefPubMed

52.

Macdougall IC, Canaud B, de Francisco AL, Filippatos G, Ponikowski P, Silverberg D et al (2012) Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency. Eur J Heart Fail 14(8):882–886CrossRefPubMedPubMedCentral

53.

Klip IT, Jankowska EA, Enjuanes C, Voors AA, Banasiak W, Bruguera J et al (2014) The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur J Heart Fail 16(6):655–662CrossRefPubMed

54.

Ponikowski P, Filippatos G, Colet JC, Willenheimer R, Dickstein K, Luscher T et al (2015) The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study. Eur J Heart Fail 17(3):329–339CrossRefPubMedPubMedCentral

55.

Toblli JE, Di Gennaro F, Rivas C (2015) Changes in echocardiographic parameters in iron deficiency patients with heart failure and chronic kidney disease treated with intravenous iron. Heart Lung Circ 24(7):686–695CrossRefPubMed

56.

Van Buren P, Velez RL, Vaziri ND, Zhou XJ (2012) Iron overdose: a contributor to adverse outcomes in randomized trials of anemia correction in CKD. Int Urol Nephrol 44(2):499–507CrossRefPubMed

57.

Agarwal R, Vasavada N, Sachs NG, Chase S (2004) Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease. Kidney Int 65(6):2279–2289CrossRefPubMed

58.

Vaziri ND (2013) Understanding iron: promoting its safe use in patients with chronic kidney failure treated by hemodialysis. Am J Kidney Dis 61(6):992–1000CrossRefPubMed

59.

Ishida JH, Johansen KL (2014) Iron and infection in hemodialysis patients. Semin Dial 27(1):26–36CrossRefPubMed

60.

Anderson LJ (2011) Assessment of iron overload with T2* magnetic resonance imaging. Prog Cardiovasc Dis 54(3):287–294CrossRefPubMed

61.

Nagao M, Matsuo Y, Kamitani T, Yonezawa M, Yamasaki Y, Kawanami S et al (2014) Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac T2* magnetic resonance imaging. Am J Cardiol 113(6):1024–1030CrossRefPubMed

62.

Nagao M, Baba S, Yonezawa M, Yamasaki Y, Kamitani T, Isoda T et al (2015) Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy. Int J Cardiovasc Imaging 31(2):399–407CrossRefPubMed

63.

Ezekowitz JA, McAlister FA, Armstrong PW (2003) Anemia is common in heart failure and is associated with poor outcomes. Circulation 107(2):223–225CrossRefPubMed

64.

Opasich C, Cazzola M, Scelsi L, De Feo S, Bosimini E, Lagioia R et al (2005) Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure. Eur Heart J 26(21):2232–2237CrossRefPubMed

65.

Adlbrecht C, Kommata S, Hülsmann M, Szekeres T, Bieglmayer C, Strunk G et al (2008) Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body’s red cell volume. Eur Heart J 29(19):2343–2350CrossRefPubMed

66.

Bolger AP, Bartlett FR, Penston HS, O’Leary J, Pollock N, Kaprielian R et al (2006) Intravenous iron alone for the treatment of anemia in patients with chronic heart failure. J Am Coll Cardiol 48(6):1225–1227CrossRefPubMed

67.

Palazzuoli A, Silverberg D, Iovine F, Capobianco S, Giannotti G, Calabrò A et al (2006) Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 152(6):1096.e9–1096.e15

Titel: Iron in kidney and heart failure: from theory to practice
verfasst von: Aslihan Yerlikaya
Mustafa C. Bulbul
Baris Afsar
Tuncay Dagel
Gamze Aslan
Luminita Voroneanu
Dimitire Siriopol
Adrian Covic
Mehmet Kanbay
Publikationsdatum: 22.09.2017
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 3/2018
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-017-1708-6

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Iron in kidney and heart failure: from theory to practice

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