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European Journal of Nuclear Medicine and Molecular Imaging

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01.02.2003 | Review Article

Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?

verfasst von: Ingeborg Goethals, Christophe Van de Wiele, Paul Boon, Rudi Dierckx

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 2/2003

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Abstract

In the presurgical evaluation of patients with partial epilepsies, the most extensively studied functional neuro-imaging modality to define the origin of seizure onset is fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET). Generally, this technique reveals a widespread zone of interictal glucose hypometabolism in the region of the epileptogenic focus. However, the technique may miss the epileptogenic region and FDG PET abnormalities may extend beyond the seizure onset zone. Consequently, for the precise identification of epileptogenic regions more specific imaging probes than FDG are warranted. This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes.

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Titel: Is central benzodiazepine receptor imaging useful for the identification of epileptogenic foci in localization-related epilepsies?
verfasst von: Ingeborg Goethals
Christophe Van de Wiele
Paul Boon
Rudi Dierckx
Publikationsdatum: 01.02.2003
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 2/2003
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-002-1083-z

Springer Medizin

Abstract

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