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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Pulmonary Medicine 1/2018

Is daily physical activity affected by dynamic hyperinflation in adults with cystic fibrosis?

BMC Pulmonary Medicine > Ausgabe 1/2018
Daniela Savi, Marcello Di Paolo, Nicholas J. Simmonds, Chiara Pascucci, Serena Quattrucci, Paolo Palange
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12890-018-0623-7) contains supplementary material, which is available to authorized users.



The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).


Thirty-four clinically stable CF were studied. All patients undertook incremental cardiopulmonary exercise testing (CPET). CPET-related measurements included: oxygen uptake (V’O2), carbon dioxide production (V’CO2), ventilatory profile, work rate (W), inspiratory capacity (IC), end-expiratory lung volume (EELV). PA was assessed using the accelerometer SenseWear Pro3 Armband.


Exercise tolerance was reduced in most of patients and the mean V’O2,peak value was 75.2% of predicted (28.5 ± 4.8 ml/min/kg). Seventy % of patients responded to CPET with dynamic hyperinflation. Higher incidence of dynamic hyperinflation was found in CF males compared to CF females (p = 0.026). Patients who developed dynamic hyperinflation during CPET had higher vigorous PA (p = 0.01) and more total energy expenditure (p = 0.006) than patients who did not. EELVΔ was related to activities requiring vigorous intensity and total energy expenditure (R = 0.46, p = 0.001; R = 0.57, p <  0.001).


In adults with CF and mild to moderate lung impairment, DPA might not be limited by dynamic hyperinflation.
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