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23.03.2019 | Original Paper

Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium

verfasst von: Albina N. Minlikeeva, Rikki Cannioto, Allan Jensen, Susanne K. Kjaer, Susan J. Jordan, Brenda Diergaarde, J. Brian Szender, Kunle Odunsi, Hani Almohanna, Paul Mayor, Kirsten Starbuck, Emese Zsiros, Elisa V. Bandera, Daniel W. Cramer, Jennifer A. Doherty, Anna DeFazio, Robert Edwards, Ellen L. Goode, Marc T. Goodman, Estrid Høgdall, Keitary Matsuo, Mika Mizuno, Christina M. Nagle, Roberta B. Ness, Lisa E. Paddock, Celeste L. Pearce, Harvey A. Risch, Mary Anne Rossing, Kathryn L. Terry, Anna H. Wu, Francesmary Modugno, Penelope M. Webb, Kirsten B. Moysich, the Australian Ovarian Cancer Study Group, the Ovarian Cancer Association Consortium

Erschienen in: Cancer Causes & Control | Ausgabe 5/2019

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Abstract

Purpose

Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated.

Methods

Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, overweight/obesity weight, and physical inactivity and overall survival (OS) as well as progression-free survival (PFS) among women diagnosed with invasive epithelial ovarian carcinoma (n = 7,022). Using age- and stage-adjusted Cox proportional hazards regression models, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs) associated with joint exposure to these factors.

Results

Combined exposure to current smoking, overweight/obesity, and physical inactivity prior to diagnosis was associated with a significantly increased risk of mortality compared to women who never smoked, had normal body mass index (BMI), and were physically active (HR = 1.37; 95% CI 1.10–1.70). The association for a joint exposure to these factors exceeded that of each exposure individually. In fact, exposure to both current smoking and overweight/obesity, and current smoking and physical inactivity was also associated with increased risk of death (HR = 1.28; 95% CI 1.08–1.52, and HR = 1.26; 95% CI 1.04–1.54, respectively). The associations were of a similar magnitude when former smoking was assessed in combination with the other exposures and when excessive weight was limited to obesity only. No significant associations were observed between joint exposure to any of these factors and PFS.

Conclusions

Joint exposure to smoking, excessive weight, and physical inactivity may negatively impact survival of ovarian cancer patients. These results suggest the importance of examining the combined effect of lifestyle factors on ovarian cancer patients’ survival.

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Titel: Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium
verfasst von: Albina N. Minlikeeva
Rikki Cannioto
Allan Jensen
Susanne K. Kjaer
Susan J. Jordan
Brenda Diergaarde
J. Brian Szender
Kunle Odunsi
Hani Almohanna
Paul Mayor
Kirsten Starbuck
Emese Zsiros
Elisa V. Bandera
Daniel W. Cramer
Jennifer A. Doherty
Anna DeFazio
Robert Edwards
Ellen L. Goode
Marc T. Goodman
Estrid Høgdall
Keitary Matsuo
Mika Mizuno
Christina M. Nagle
Roberta B. Ness
Lisa E. Paddock
Celeste L. Pearce
Harvey A. Risch
Mary Anne Rossing
Kathryn L. Terry
Anna H. Wu
Francesmary Modugno
Penelope M. Webb
Kirsten B. Moysich
the Australian Ovarian Cancer Study Group
the Ovarian Cancer Association Consortium
Publikationsdatum: 23.03.2019
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 5/2019
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-019-01157-3

Springer Medizin

Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium