Inflammopharmacology OnlineFirst articles

27.09.2023 | Original Article

Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer’s disease activity in Wister rat model

Lately, interest surrounding the utilization of plant-derived compounds as a viable beneficial approach for treating Alzheimer’s disease (AD) has significantly increased. This study aimed to assess the defensive properties of rosavin against …

verfasst von:: Meiyi Huang, Rubo Sui, Lei Zhang, Yue Zhu, Xueling Yuan, Hongxin Jiang, Xin Mao

27.09.2023 | Review Article

Salsalate: a pleotropic anti-inflammatory drug in the treatment of diabetes, obesity, and metabolic diseases

Type two Diabetes Mellitus (T2DM) is a rising epidemic. Available therapeutic strategies have provided glycaemic control via HbA1c reduction but fail to provide clinically meaningful reduction in microvascular and macrovascular (cardiac, renal …

verfasst von:: I. Hasan, K. D. Rainsford, Joel S. Ross

27.09.2023 | Original Article

Topical application of a TRPA1 antagonist reduced nociception and inflammation in a model of traumatic muscle injury in rats

Musculoskeletal pain is a widely experienced public healthcare issue, especially after traumatic muscle injury. Besides, it is a common cause of disability, but this pain remains poorly managed. However, the pathophysiology of traumatic muscle …

verfasst von:: Sabrina Qader Kudsi, Caren Tatiane de David Antoniazzi, Camila Camponogara, Graziela Moro Meira, Marcella de Amorim Ferreira, Ana Merian da Silva, Diéssica Padilha Dalenogare, Rubya Zaccaron, Carolina dos Santos Stein, Paulo Cesar Lock Silveira, Rafael Noal Moresco, Sara Marchesan Oliveira, Juliano Ferreira, Gabriela Trevisan

23.09.2023 | Review

Attention-deficit/hyperactivity disorder and inflammation: natural product-derived treatments—a review of the last ten years

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by symptoms of inattention, hyperactivity, and impulsivity (APA 2013 ). Epidemiological data indicate that the global prevalence of ADHD is …

verfasst von:: Alexandre Martins, Magali Conte, Márcia Inês Goettert, Verônica Contini

Open Access 20.09.2023 | Original Article

Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane

Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain without serious adverse effects. The aim of this study was to investigate the antinociceptive and anti-inflammatory activities …

verfasst von:: Omar Guadarrama-Enríquez, Gabriel Fernando Moreno-Pérez, María Eva González-Trujano, Guadalupe Esther Ángeles-López, Rosa Ventura-Martínez, Irene Díaz-Reval, Agustina Cano-Martínez, Francisco Pellicer, Nieves Baenas, Diego A. Moreno, Cristina García-Viguera

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Open Access 19.09.2023 | Original Article

Hyaluronic acid/diminazene aceturate combination ameliorates osteoarthritic anomalies in a rodent model: a role of the ACE2/Ang1-7/MasR axis

The implication of the tissue-localized renin-angiotensin system (RAS) in the pathogenesis of osteoarthritis (OA) has been documented in the last decades. A combination of intraarticular (IA) corticosteroid and hyaluronic acid (HYAL) is approved …

verfasst von:: Yasser H. Habib, Eman Sheta, Mahmoud Khattab, Mennatallah A. Gowayed

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08.09.2023 | Original Article

John Alexander Mullin (1835–1899): The Canadian Physician who first described Osler’s Nodes

Sir William Osler (1849–1919), who became Regius Professor of Medicine at Oxford in 1905, first drew attention in 1909 to the painful nodes in subacute bacterial endocarditis, which now carry his eponym, and he published an account in the …

verfasst von:: W. Watson Buchanan, K. D. Rainsford, Colin A. Kean, Walter F. Kean

07.09.2023 | Original Article

The illness of William Soutar (1898–1943)

William Soutar (1898–1943) was a Scottish poet, but many are unaware of his scholarly work which includes his famous “brain-rhymes”. He was born in Perth Scotland in 1898. He was educated at Perth Primary School and Perth Academy and proved to be …

verfasst von:: W. Watson Buchanan, K. D. Rainsford, Colin A. Kean, Walter F. Kean

07.09.2023 | Original Article

Spondyloarthropathies and arthritis post-infection: a historical perspective

The spondyloarthropathies are a group of conditions characterised by spinal joint pain and have related clinical, epidemiological and genetic-related features. Ankylosing spondylitis, reactive arthritis, the spinal form of psoriatic arthritis and …

verfasst von:: W. Watson Buchanan, Colin A. Kean, K. D. Rainsford, Walter F. Kean

07.09.2023 | Original Article

Medical aspects of the tour by Martin Martin (c 1660–1719) of the Western and Northern Islands of Scotland, Circa 1695

This review is based investigations on the Western Isles, Scotland, by Martin Martin, a notable Scottish Highlander, academic and medical doctor, of the 17th–18th century. His extensive observations of the geography and peoples of these Isles were …

verfasst von:: W. Watson Buchanan, K. D. Rainsford, Colin A. Kean, Walter F. Kean

26.08.2023 | Review

Treatment of rheumatic musculoskeletal disorders

Non-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centuries and continue to be of benefit for some people with musculoskeletal disorders. Historical texts refer to the two …

verfasst von:: W. Watson Buchanan, K. D. Rainsford, Colin A. Kean, Walter F. Kean

24.08.2023 | Original Article

High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis

Sepsis is a complex, multifactorial syndrome characterized by a dysregulated host response to infection, leading to severe organ dysfunction and high mortality rates among critically ill patients. Hypovitaminosis C and vitamin C deficiency are …

verfasst von:: Xiaoting Zhang, Wentao Ji, Xiaoming Deng, Lulong Bo

23.08.2023 | Original Article

Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide

Folic acid (FA) plays an important role in the maintenance of normal neurological functions such as memory and learning function. Neuroinflammation contributes to the progression of cognitive disorders and Alzheimer’s disease. Thus, this study …

verfasst von:: Zahra Kioumarsi Darbandi, Sabiheh Amirahmadi, Iran Goudarzi, Mahmoud Hosseini, Arezoo Rajabian

14.08.2023 | Original Article

Sesquiterpene from Artemisia argyi seed extracts: A new anti-acute peritonitis agent that suppresses the MAPK pathway and promotes autophagy

To find novel anti-inflammatory drugs, we screened anti-inflammatory compounds from 18 different types of Artemisia argyi seed extracts. The in vitro and in vivo anti-inflammatory activities of the screened compounds and their mechanisms were …

verfasst von:: Yinchao Li, Yuanhui Wang, Tianxin Li, Zhenzhen Li, Tao Guo, Guimin Xue, Yongtao Duan, Yongfang Yao

14.08.2023 | Original Article

Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury

Spinal cord injury (SCI) is usually accompanied by sensory, motor, and autonomic nerve dysfunction, which leads to lifelong disability and brings a heavy economic burden to society (Anjum et al. 2020 ). However, there is currently no cure. SCI is …

verfasst von:: Wenshan Shan, Jiawei Wang, Rui Cheng, Yong Xuan, Zongsheng Yin

Open Access 12.08.2023 | Original Article

LC-QToF chemical profiling of Euphorbia grantii Oliv. and its potential to inhibit LPS-induced lung inflammation in rats via the NF-κB, CY450P2E1, and P38 MAPK14 pathways

Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. The aerial parts of Euphorbia grantii Oliv. were extracted with methanol to give a total methanolic extract (TME), which was further …

verfasst von:: Mai Hussin Radi, Riham A. El-Shiekh, Amany Mohammed Hegab, Shirley Ragae Henry, Bharathi Avula, Kumar Katragunta, Ikhlas A. Khan, Ali M. El-Halawany, Essam Abdel-Sattar

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09.08.2023 | Commentary

A need for clinical trial: re-purposing the Monoamine Oxidase Inhibitors (MAO-I) for rheumatoid arthritis (RA)

There is a group of enzymes called monoamine oxidase(s) (MAOs) that help with the oxidation of amines found in both our diet and our bodies. Currently, monoamine oxidase inhibitors (MAO-Is) are utilized to manage conditions like depression …

verfasst von:: Asis Bala

06.08.2023 | Original Article

Appraisal of anti-inflammatory and immunomodulatory potential of ramipril against Freund’s adjuvant-provoked arthritic rat model

Because of evident role of renin–angiotensin system in the etiology of rheumatoid arthritis, the current study’s objective was to assess the anti-arthritic efficacy of ramipril through CFA-instigated arthritic model. The drug has been shown to …

verfasst von:: Sumera Qasim, Yusra Habib Khan, Ambreen Malik Uttra, Nasser Hadal Alotaibi, Abdullah Salah Alanazi, Abdulaziz I. Alzarea, Ahmed D. Alatawi, Tauqeer Hussain Mallhi

05.08.2023 | Original Article

Acyclic monoterpenoid-rich essential oil of Cymbopogon distans mitigates skin inflammation: a chemico-pharmacological study

The topical application of essential oils is considered an effective treatment for skin diseases. Cymbopogon distans (Nees ex Steud.) Wats (Poaceae) is a promising aromatic grass widespread in the Himalayan temperate zone. Therefore, using …

verfasst von:: Divya Bhatt, Swati Singh, Munmun Kumar Singh, Anil Kumar Maurya, Amit Chauhan, Rajendra Chandra Padalia, Ram Swaroop Verma, Dnyaneshwar U. Bawankule

Open Access 04.08.2023 | Original Article

PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson’s disease in rats

Parkinson’s disease (PD) is the second most common progressive age-related neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT signaling activation in the treatment of neurodegenerative disorders. PI3K/AKT signaling …

verfasst von:: Heba A. Farid, Rabab H. Sayed, Marwa El-Sayed El-Shamarka, Omar M. E. Abdel-Salam, Nesrine S. El Sayed

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