Journal of Assisted Reproduction and Genetics OnlineFirst articles

24.04.2024 | Reproductive physiology and disease

Follicular fluid-derived exosomal LncRNA LIPE-AS1 modulates steroid metabolism and survival of granulosa cells leading to oocyte maturation arrest in polycystic ovary syndrome

Women of reproductive age who have polycystic ovary syndrome (PCOS) are affected by the endocrine conditions that are characterized by hyperandrogenism, polycystic ovarian morphology, and chronic anovulation [ 1 , 2 ]. The primary cause of …

verfasst von:: Li Yu, Chen Wang, Miao Liu, Lingjin Xia, Te Liu, Qi Che, Wei Cai, Xi Dong, Baishen Pan, Beili Wang, Suying Liu, Wei Guo

Open Access 20.04.2024 | Assisted Reproduction Technologies

Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles

Leukocytospermia, defined as the presence of ≥ 1 × 10 6 white blood cells/mL of semen according to the 6th edition of the WHO Manual for the Laboratory Examination and Processing of Human Semen [ 1 ], is commonly identified in the semen analyses of …

verfasst von:: Pavan Gill, Nicolas Garrido Puchalt, Thomas Molinaro, Marie Werner, Emre Seli, James Hotaling, Philip Cheng

PDF-Version jetzt herunterladen Zum Volltext

Open Access 20.04.2024 | Genetics

Aneuploidy detection in pooled polar bodies using rapid nanopore sequencing

Increasing the live birth rate and decreasing the miscarriage rate through in vitro fertilisation (IVF) treatment is a critical focus of reproductive medicine, specifically in combination with advanced maternal age [ 1 ]. A study showed that in …

verfasst von:: Silvia Madritsch, Vivienne Arnold, Martha Haider, Julia Bosenge, Mateja Pfeifer, Beatrix Weil, Manuela Zechmeister, Markus Hengstschläger, Jürgen Neesen, Franco Laccone

PDF-Version jetzt herunterladen Zum Volltext

20.04.2024 | Assisted Reproduction Technologies

Effect of time post warming to embryo transfer on human blastocyst metabolism and pregnancy outcome

The timing of embryo transfer for patients going through an In Vitro Fertilization (IVF) treatment is of major importance to enable high success rates. To navigate and avoid the possible adverse effect following controlled ovarian stimulation …

verfasst von:: Goli Ardestani, Marion Martins, Olcay Ocali, Tim H. Sanchez, Colwyn Gulliford, C. Brent Barrett, Denny Sakkas

Open Access 18.04.2024 | Assisted Reproduction Technologies

Rescue intrauterine insemination in women failing to retrieve oocytes at ovum pick-up: report of a case series

Failure to collect oocytes at the time of oocyte pick-up, despite a presumed correct timing of the human chorionic gonadotropin (hCG) trigger, is an unfavorable outcome of in vitro fertilization (IVF) cycles [ 1 ]. This rare event is more common in …

verfasst von:: Ludovico Muzii, Giulia Galati, Ilenia La Barbiera, Antonella Linari, Oriana Capri, Daniela Pietrangeli, Edgardo Somigliana

PDF-Version jetzt herunterladen Zum Volltext

18.04.2024 | Acknowledgments

Acknowledgement to scientific referees

17.04.2024 | Review

Decision-making for congenital anomalies diagnosed during pregnancy: a narrative review

In 2–3% of pregnancies, even among those with negative early prenatal genetic screening, there will be fetal anomalies diagnosed in the second trimester of pregnancy at the time of ultrasound, evaluating fetal anatomy [ 1 ]. While some prenatally …

verfasst von:: Jillian Pecoriello, Anna- Grace Lilly, Dona Jalili, Clarisa Mendoza, Gwendolyn P. Quinn, Christina A. Penfield

Open Access 15.04.2024 | Fertility Preservation

Utilizing artificial intelligence in academic writing: an in-depth evaluation of a scientific review on fertility preservation written by ChatGPT-4

Millions of people now use artificial intelligence (AI)–based language models, such as ChatGPT, capable of mimicking human communication and generating coherent texts in seconds [ 1 ]. In response to specific prompts, ChatGPT can produce …

verfasst von:: Myriam Safrai, Kyle E. Orwig

PDF-Version jetzt herunterladen Zum Volltext

13.04.2024 | Assisted Reproduction Technologies

Oocyte cryopreservation on TikTok and Instagram: Who is teaching whom?

Social media platforms, such as Instagram, Twitter, TikTok, Facebook and YouTube, serve as popular channels to spread information. In 2021, it was estimated that 4.26 billion people were using social media worldwide, including more than 1 billion …

verfasst von:: Alexandra M. Herweck, Paris Chey, Heather S. Hipp, Jennifer F. Kawwass

13.04.2024 | Embryo Biology

Evaluating the developmental potential of 2.1PN-derived embryos and associated chromosomal analysis

Normal fertilization is defined as the presence of zygotes with two pronuclei (2PN) and two polar bodies (PBs) at 16–18 h following insemination. Oocytes with an abnormal number of PN are defined as abnormally fertilized oocytes (AFOs). In in …

verfasst von:: Jiang Wang, Shun Xiong, Xiangwei Hao, Yang Gao, Fei Xia, Haiyuan Liao, Jiayi Zou, Guoning Huang, Wei Han

Open Access 13.04.2024 | Embryo Biology

The utility of human two plus one small pronucleated zygotes (2.1PN) based on clinical outcomes and the focused ploidy analysis

Human in vitro fertilization (IVF), either conventional IVF or intracytoplasmic sperm injection (ICSI), is performed after oocyte retrieval, followed by confirmation of fertilization by checking the number and shape of pronuclei (PN) and the …

verfasst von:: Hiromitsu Hattori, Noriyuki Okuyama, Kyota Ashikawa, Yoshiyuki Sakuraba, Hideki Igarashi, Koichi Kyono

PDF-Version jetzt herunterladen Zum Volltext

11.04.2024 | Assisted Reproduction Technologies

High estradiol levels in fresh embryo transfer cycles are not associated with detrimental impact on birth outcomes

Fresh embryo transfer (ET) versus a freeze-all approach during in vitro fertilization (IVF) remains disputed within our field [ 1 , 2 ]. A freeze-all approach appears to benefit select patient populations, such as patients at risk for ovarian …

verfasst von:: Ivy L. Lersten, Laura Grau, Samad Jahandideh, Kate Devine, Laura Zalles, Shayne M. Plosker, Anthony N. Imudia, Luis R. Hoyos, Meike L. Uhler, Michael Homer, Cassandra Roeca, Mary D. Sammel, Alex J. Polotsky

05.04.2024 | Genetics

PGT-M for spinocerebellar ataxia type 1: development of a STR panel and a report of two clinical cases

Spinocerebellar ataxia type 1 (SCA1) (OMIM 164400) is a late-onset autosomal dominant disease that belongs to a heterogeneous group of neurodegenerative hereditary diseases caused by the trinucleotide repeats expansion. SCA1 is caused by mutations …

verfasst von:: Elena V. Soloveva, Maria M. Skleimova, Larisa I. Minaycheva, Anna F. Garaeva, Daria I. Zhigalina, Egor O. Churkin, Yulia V. Okkel, Oksana S. Timofeeva, Ilya A. Petrov, Gulnara N. Seitova, Igor N. Lebedev, Vadim A. Stepanov

Open Access 04.04.2024 | Assisted Reproduction Technologies

Exploring gonadotropin dosing effects on MII oocyte retrieval in ovarian stimulation

Controlled ovarian stimulation (COS) by exogenous gonadotropins stimulates the development of follicles to obtain mature oocytes with a preserved reproductive potential for in vitro fertilization (IVF). The stimulation protocol is preceded by …

verfasst von:: Krystian Zieliński, Anna Kloska, Piotr Wygocki, Marcin Zieleń, Michał Kunicki

PDF-Version jetzt herunterladen Zum Volltext

03.04.2024 | Fertility Preservation

Thymoquinone effects on autophagy, apoptosis, and oxidative stress in cisplatin-induced testicular damage in mice

Cisplatin (CP) is effective against many malignancies, such as sarcoma, lymphoma, and breast cancers. However, CP has toxic impacts on the reproductive system and induces azoospermia in patients undergoing chemotherapy [ 1 , 2 ].

verfasst von:: Mina Shojaedini, Masoud Hemadi, Ghasem Saki, Fereshtehsadat Fakhredini, Mohammad Javad Khodayar, Layasadat Khorsandi

Open Access 03.04.2024 | Assisted Reproduction Technologies

Can serum progesterone concentration direct a fresh or freeze-all transfer strategy in the first in vitro fertilisation cycle?

Historically, most fertility clinics worldwide have practiced fresh embryo transfer, with frozen transfer of surplus embryos. Fresh embryo transfer is associated with increased chances ovarian hyperstimulation and studies suggest that there are …

verfasst von:: Sarah Hunt, Jing Liu, Pulin Luo, Ying Zhong, Ben W. Mol, Ling Chi, Rui Wang

PDF-Version jetzt herunterladen Zum Volltext

03.04.2024 | Genetics

Novel SPEF2 variants cause male infertility and likely primary ciliary dyskinesia

Infertility refers to the failure to achieve pregnancy after 12 months of regular, unprotected sexual intercourse [ 1 ] and has become a significant global health issue, affecting approximately 15% of couples worldwide [ 2 ]. Male-related factors …

verfasst von:: Wenqing Lu, Yong Li, Lanlan Meng, Chen Tan, Hongchuan Nie, Qianjun Zhang, Yuying Song, Huan Zhang, Yue-Qiu Tan, Chaofeng Tu, Haichun Guo, Longxiang Wu, Juan Du

02.04.2024 | Commentary

Redefining human reproductive physiology as revealed by inefficiencies of contemporary ARTs

verfasst von:: David F. Albertini

01.04.2024 | Assisted Reproduction Technologies

The impact of a second embryo biopsy for preimplantation genetic testing for monogenic diseases (PGT-M) with inconclusive results on pregnancy potential: results from a matched case–control study

Preimplantation genetic testing for monogenic diseases (PGT-M) allows for genetic profiling of embryos prior to implantation in couples with hereditary genetic disorders, as part of the in vitro fertilization (IVF) process. According to the ESHRE …

verfasst von:: Cristina Guarneri, Marco Reschini, Monica Pinna, Lucia Perego, Elena Sanzani, Edgardo Somigliana, Ugo Sorrentino, Matteo Cassina, Daniela Zuccarello, Marta Ciaffaglione

01.04.2024 | Embryo Biology

Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos

The development of the CRISPR/Cas9 genome editing tool, an acronym for ‘clustered regularly interspaced short palindromic repeats’ (CRISPR)/ ‘CRISPR-associated protein 9’ (Cas9), has revolutionised our ability to introduce specific changes inside …

verfasst von:: B. Bekaert, A. Boel, A. Rybouchkin, G. Cosemans, S. Declercq, S. M. Chuva de Sousa Lopes, J. Parrington, D. Stoop, P. Coucke, B. Menten, B. Heindryckx

Springer Medizin