The past two decades have seen significant advances in the treatment of pediatric patients with cancer, though a number of challenges and uncertainties remain. These include diagnostic and therapeutic obstacles, as well as negative …
verfasst von:
Eran Ben-Arye, Noah Samuels, Georg Seifert, Orit Gressel, Raviv Peleg, Miek Jong
Cyclin-dependent kinases (CDKs) are a group of serine/threonine kinases that have important roles in controlling cell cycle progression. The CDK4 and 6 (CDK4/6) and related retinoblastoma (Rb) pathways are commonly dysregulated in human cancers …
verfasst von:
Tara Magge, Sneha Rajendran, Adam M. Brufsky, Julia Foldi
Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder affecting 1 in 3000 individuals caused by germline mutation of the NF1 gene. The NF1 gene product neurofibromin is a Ras GTPase-activating protein (RAS-GAP) that converts …
More than 17 million people in the United States are living with cancer, with the population of cancer survivors expected to reach 26 million by 2040 [ 1 ]. Extraordinary advancements in the diagnosis and treatment of malignancy has resulted in a …
verfasst von:
Reema Sabeeha Martini, Terrell Brown, Vinita Singh, Anna Woodbury
Minimal (Measurable) Residual Disease (MRD) in multiple myeloma (MM) refers to the disease burden that remains following therapeutic intervention that may be detectable by highly sensitive assays. It has emerged as one of the strongest prognostic …
verfasst von:
Mina Meseha, James Hoffman, Dickran Kazandjian, Ola Landgren, Benjamin Diamond
With the age of monoclonal antibodies (mabs) ushered in by Köhler and Milstein’s 1975 breakthrough in hybridoma technology, there came potential for developing specific, targeted cancer therapeutics. One of the most significant has been …
verfasst von:
Aruni Ghose, Patricia Lapitan, Vedika Apte, Adheesh Ghosh, Abhinav Kandala, Sreejana Basu, Jo Parkes, Sayali D. Shinde, Stergios Boussios, Anand Sharma, Prantik Das, Nikhil Vasdev, Sara E. Rebuzzi, Yüksel Ürün, Ravindran Kanesvaran, Akash Maniam, Giuseppe L. Banna
Breast cancer remains the most prevalent malignancy affecting women in the USA [ 1 ]. Despite improvements in survival and quality-of-life, a subset of patients develop metastatic disease, which continues to be a leading cause of cancer-related …
As the number of new cancer diagnoses and available treatment modalities continues to grow, a corresponding call for improvement in the delivery of care for patients with cancer has emerged [ 1 ]. “Digital health” is an evolving field that can be …
verfasst von:
Robert Haemmerle, Jonas Paludo, Tufia C. Haddad, Joshua C. Pritchett
The surgical landscape for advanced laryngeal cancer (LC) has undergone significant transformations since the first total laryngectomy, carried out in 1873, marking over 150 years of evolution toward strategies aiming to the preservation of the …
verfasst von:
Erika Crosetti, Marco Fantini, Ilaria Bertotto, Andy Bertolin, Giulia Arrigoni, Andrea Lorenzi, Giovanni Succo
Percutaneous thermal ablation is an important component of the multidisciplinary management of both primary and metastatic sarcomas, providing a minimally invasive alternative or adjunct to surgery and radiation therapy. Although the literature …
verfasst von:
Ahmad Parvinian, Scott M. Thompson, John J. Schmitz, Brian T. Welch, Rebecca Hibbert, Daniel A. Adamo, A. Nicholas Kurup
There are nearly 1 million women under the age of 50 years living with cancer in the USA in 2022 [ 1 ]. With a cancer diagnosis comes countless diagnostic and treatment decisions to be made, some of which are not necessarily limited to the cancer …
verfasst von:
Mary Kathryn Abel, Ange Wang, Joseph M. Letourneau, Michelle E. Melisko, Marcelle I. Cedars, Mitchell P. Rosen
