European Journal of Nuclear Medicine and Molecular Imaging OnlineFirst articles

24.04.2024 | Letter to the Editor

Letter to the editor concerning “Cardiac [99mTc]Tc-hydroxydiphosphonate uptake on bone scintigraphy in patients with hereditary transthyretin amyloidosis: an early follow-up marker?”

verfasst von:: An-Li Yu, Cheng-Hsuan Tsai, Mei-Fang Cheng, Yen-Hung Lin

23.04.2024 | Editorial

How nuclear imaging changed parathyroid surgical strategies through time

In 1986, John Doppman made the statement that “the only localization study indicated in a patient with untreated hyperparathyroidism (HPT) is the localization of an experienced parathyroid surgeon” [ 1 ]. Nowadays, preoperative localization with …

verfasst von:: H. M. Schouw, M. E. Noltes, A. H. Brouwers, I.-L. Nilsson, J. Zedenius, S. Kruijff

22.04.2024 | Original Article

Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging

The rising incidence of prostate cancer (PCa) globally, particularly in Western countries, positions it as the fourth most common cancer and a leading cause of cancer-related death in men [ 1 – 3 ]. Despite radical prostatectomy being the primary …

verfasst von:: Yaqi Tian, Hongliang Shen, Lingbing Li, Xiaohua Jia, Jin Liu, Zhenhua Hu, Liang Wang, Jie Tian

Open Access 22.04.2024 | Original Article

Synthesis and preclinical evaluation of novel 18F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography

Bacterial infections are a major problem in medicine, and they impose an enormous economic burden on society. It is estimated that, in Europe alone, 4.1 million patients suffer from 8.9 million healthcare-associated infections (HAIs) each year [ 1 …

verfasst von:: G. B. Spoelstra, S. N. Blok, L. Reali Nazario, L. Noord, Y. Fu, N. A. Simeth, F. F. A. IJpma, M. van Oosten, J. M. van Dijl, B. L. Feringa, W. Szymanski, P. H. Elsinga

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20.04.2024 | Original Article

Combined, yet separate: cocktails of carriers (not drugs) for actinium-225 α-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers

Radionuclide-antibody conjugates are among the leading approaches in targeted alpha-particle (α-particle) therapies including the treatment of vascularized, soft-tissue, solid tumors overexpressing the antibody-targeted cell markers [ 1 ].

verfasst von:: Rajiv Ranjit Nair, Aprameya Prasad, Omkar Bhatavdekar, Aira Sarkar, Kathleen L. Gabrielson, Stavroula Sofou

19.04.2024 | Original Article

The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions

Magnetic resonance imaging (MRI) is currently the gold standard for characterizing brain lesions, planning treatment and monitoring brain tumors [ 1 , 2 ]. Amino acid PET is nevertheless strongly recommended by the Response Assessment in …

verfasst von:: Adeline Zinsz, Celso Pouget, Fabien Rech, Luc Taillandier, Marie Blonski, Samir Amlal, Laetitia Imbert, Timothée Zaragori, Antoine Verger

18.04.2024 | Original Article

Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer

PSMA (prostate specific membrane antigen) radioligand therapy (RLT) with Lutetium-177 [ 177 Lu]Lu-PSMA-617 (vipivotide tetraxetan) is effective in prolonging radiographic progression free survival (rPFS) and overall survival (OS) in metastatic …

verfasst von:: Hong Song, Maria Isabel Leonio, Valentina Ferri, Heying Duan, Carina Mari Aparici, Guido Davidzon, Benjamin L. Franc, Farshad Moradi, Jagruti Shah, Colin P. Bergstrom, Alice C. Fan, Sumit Shah, Ali Raza Khaki, Sandy Srinivas, Andrei Iagaru

18.04.2024 | Original Article

B-Glycine as a marker for β cell imaging and β cell mass evaluation

Islet is highly involved in BS (blood sugar) control, accounting for the unique recourse of insulin [ 1 ]. Hyperfunction of islets leads to neurogenic hypoglycemia. The damage of islets can lead to acute diseases, such as T1D [ 2 – 4 ]. For …

verfasst von:: Yuxiang Han, Hui Liu, Yimin Li, Zhibo Liu

Open Access 16.04.2024 | Original Article

Cadherin-17 as a target for the immunoPET of adenocarcinoma

Cadherins are a superfamily of calcium-dependent proteins that mediate cell adhesion [ 1 – 3 ]. One member of this family — cadherin-17 (CDH17; liver intestine cadherin or LI-cadherin) — is typically expressed by intestinal epithelial cells [ 4 , 5 …]. However, several types of adenocarcinoma cells overexpress CDH17, fueled by phosphorylation cascades within the ⍺

verfasst von:: Samantha Delaney, Outi Keinänen, Dennis Lam, Andrew L. Wolfe, Takao Hamakubo, Brian M. Zeglis

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12.04.2024 | Review Article

Intraoperative image-guidance during robotic surgery: is there clinical evidence of enhanced patient outcomes?

Currently, robot-assisted systems allow the performance of the majority of complex surgeries, traditionally conducted with either an open or a laparoscopic approach. Surgical experience is maximally enhanced by utmost movement precision, excellent …

verfasst von:: Stefano Tappero, Giuseppe Fallara, Francesco Chierigo, Andrea Micalef, Francesca Ambrosini, Raquel Diaz, Andrea Dorotei, Edoardo Pompeo, Alessia Limena, Carlo Andrea Bravi, Mattia Longoni, Mattia Luca Piccinelli, Francesco Barletta, Luigi Albano, Elio Mazzone, Paolo Dell’Oglio

09.04.2024 | Review Article

Visual extended reality tools in image-guided surgery in urology: a systematic review

Over the past few decades, urologic surgery has undergone a profound transformation. The emergence of laparoscopic and robotic techniques has completely changed the landscape of minimally invasive surgery, gaining increasing favor among surgeons …

verfasst von:: Enrico Checcucci, Alberto Piana, Gabriele Volpi, Alberto Quarà, Sabrina De Cillis, Federico Piramide, Mariano Burgio, Juliette Meziere, Edoardo Cisero, Marco Colombo, Gabriele Bignante, Michele Sica, Stefano Granato, Paolo Verri, Cecilia Gatti, Paolo Alessio, Michele Di Dio, Stefano Alba, Cristian Fiori, Daniele Amparore, Francesco Porpiglia

Open Access 08.04.2024 | Original Article

Clinicopathological and molecular predictors of [18F]FDG-PET disease detection in HER2-positive early breast cancer: RESPONSE, a substudy of the randomized PHERGain trial

Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) is a clinically and biologically heterogeneous disease [ 1 ] characterized by the amplification of the ERBB2/HER2 gene and/or overexpression of its related kinase receptor …

verfasst von:: Antonio Llombart-Cussac, Aleix Prat, José Manuel Pérez-García, José Mateos, Tomás Pascual, Santiago Escrivà-de-Romani, Agostina Stradella, Manuel Ruiz-Borrego, Begoña Bermejo de las Heras, Marleen Keyaerts, Patricia Galvan, Fara Brasó-Maristany, Juan José García-Mosquera, Thomas Guiot, María Gion, Miguel Sampayo-Cordero, Serena Di Cosimo, Jhudit Pérez-Escuredo, Manuel Atienza de Frutos, Javier Cortés, Geraldine Gebhart

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08.04.2024 | Original Article

PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans

The World Health Organization (WHO) reports that the current global incidence of depression is about 3.8%, meaning there are over 300 million people with depression worldwide [ 1 ]. Given the high incidence, high suicide, high recurrence and high …

verfasst von:: Zhiwei Huang, Junhao Wu, Yihui Guan, Yumei Wei, Fang Xie, Yifeng Shen

Open Access 08.04.2024 | Original Article

Targeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer

Patients with triple-negative breast cancer (TNBC) suffer from poor prognosis due to limited therapeutic options, low response rate, and high relapse rate [ 1 ]. One possible mechanism for this refractory disease lies in the coordinated interplay …

verfasst von:: Guangfa Bao, Ziqiang Wang, Luoxia Liu, Buchuan Zhang, Shuang Song, Dongdong Wang, Siyuan Cheng, Eu-Song Moon, Frank Roesch, Jun Zhao, Bo Yu, Xiaohua Zhu

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08.04.2024 | Editorial

Artificial intelligence-based application in multiple myeloma

verfasst von:: Leandra Piscopo, Mariano Scaglione, Michele Klain

06.04.2024 | Original Article

An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes

Fluorescence-guided surgery (FGS) has revolutionized the field of cancer surgery by allowing surgeons to identify tumor margins and tumor-adjacent lymph nodes (LNs) using fluorescent fluorophores in real time [ 1 ]. The introduction of …

verfasst von:: Yajun Wang, Ding Zhou, Huilong Ma, Dahai Liu, Yongye Liang, Shoujun Zhu

Open Access 04.04.2024 | Editorial

Highlights of the 36th EANM Annual Congress 2023, from hometown Vienna, Austria: “A SYMPHONY OF SCIENCE”

Between the 9th and 13th of September 2023, the international nuclear medicine community gathered in Vienna, hometown to the headquarters of the European Association of Nuclear Medicine (EANM), for its 36th Annual Congress. EANM encompasses 40 …

verfasst von:: David Kersting, Silvia Morbelli, Sophie E. M. Veldhuijzen van Zanten, Hein J. Verberne

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Open Access 04.04.2024 | Original Article

Optimizing the pharmacokinetics of an 211At-labeled RGD peptide with an albumin-binding moiety via the administration of an albumin-binding inhibitor

Radiotheranostics combines nuclear medicine imaging and radionuclide therapy [ 1 – 4 ]. Radionuclide therapy with α-emitters known as targeted alpha therapy (TAT) has attracted much attention due to its stellar therapeutic effects [ 5 , 6 ]. Among …

verfasst von:: Hiroaki Echigo, Masayuki Munekane, Takeshi Fuchigami, Kohshin Washiyama, Kenji Mishiro, Hiroshi Wakabayashi, Kazuhiro Takahashi, Seigo Kinuya, Kazuma Ogawa

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03.04.2024 | Image of the Month

Latent phosphaturic mesenchymal tumor in left planta detected by [18F]F-AlF-NOTA-octreotide PET/CT

verfasst von:: Congcong Yu, Lin Chen, Rui Zhou, Hong Zhang

02.04.2024 | Short Communication

Initial [18F]DCFPyL PET/CT in treatment-naïve prostate cancer: correlation with post-ADT PSA outcomes and recurrence

Prostate cancer (PCa) remains an area of intense medical concern, being documented as the second most prevalent cancer in males globally [ 1 ]. Positron emission tomography (PET) has emerged as an indispensable tool in the diagnostic arsenal …

verfasst von:: Yuekai Li, Shiwei Wang, Shimin Zhao, Pengfei Zhao, Shuai Huang, Kaiyue Li, Shaoli Han, Caixia Tian, Xin Li, Benkang Shi, Xiang Li

Springer Medizin