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Journal of Neurology OnlineFirst articles

19.04.2019 | Neurological Update

Update on narcolepsy

The last two decades have seen an explosion in our understanding of the clinical nature of narcolepsy and its pathogenesis, fuelling new approaches to potentially effective treatments. It is now recognised that the full narcoleptic syndrome has …

P. J. Reading

19.04.2019 | Original Communication

High-intensity training in patients with spinal and bulbar muscular atrophy

Patients with spinal and bulbar muscular dystrophy (SBMA) suffer from degeneration of the motor neurons leading to progressive atrophy and weakness of bulbar and extremity muscles.

Karen Heje, Grete Andersen, Astrid Buch, Henning Andersen, John Vissing

19.04.2019 | Original Communication

In search of distinct MS-related fatigue subtypes: results from a multi-cohort analysis in 1.403 MS patients

Fatigue is among the most disabling symptoms in patients with multiple sclerosis (PwMS). The common distinction between cognitive and motor fatigue is typically incorporated in self-rating instruments, such as the Chalder Fatigue Questionnaire …

Gesa E. A. Pust, Jana Pöttgen, Jennifer Randerath, Stephanie Lau, Christoph Heesen, Stefan M. Gold, Iris-Katharina Penner

19.04.2019 | Letter to the Editors

Anti-natalizumab antibodies during 8 years of natalizumab treatment: effect on natalizumab concentration and α4-integrin receptor saturation

Zoé L. E. van Kempen, Johannis A. van Rossum, Djoeke Doesburg, Iris Claessen, Annick de Vries, Anja ten Brinke, Bob W. van Oosten, Theo Rispens, Joep Killestein

17.04.2019 | Original Communication Open Access

Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson’s disease

Hyperhidrosis is one of the least studied non-motor symptoms (NMS) in Parkinson’s disease (PD). Sweating disorders in PD include mainly hyperhidrosis, but also hypohydrosis, and the prevalence is reported by some at 64% of PD patients, compared to …

Daniel J. van Wamelen, Valentina Leta, Aleksandra M. Podlewska, Yi-Min Wan, Katarina Krbot, Elina Jaakkola, Pablo Martinez-Martin, Alexandra Rizos, Miriam Parry, Vinod Metta, Kallol Ray Chaudhuri

15.04.2019 | Original Communication Open Access

Prevalence and risk factors of stroke in the elderly in Northern China: data from the National Stroke Screening Survey

Stroke is the second most frequent cause of death and a leading cause of disability worldwide [ 1 ]. Although age-standardized rates of stroke mortality have decreased worldwide in the past two decades, the absolute numbers of people who have a …

Xiaoshuang Xia, Wei Yue, Baohua Chao, Mei Li, Lei Cao, Lin Wang, Ying Shen, Xin Li

15.04.2019 | Letter to the Editors

Can verapamil be effective in controlling vertigo and headache attacks in vestibular migraine accompanied with Meniere’s disease? A preliminary study

Isa Kaya, Sevinc Eraslan, Ceyda Tarhan, Cem Bilgen, Tayfun Kirazli, Figen Gokcay, Hale Karapolat, Nese Celebisoy

15.04.2019 | Pioneers in Neurology

Vernon B. Mountcastle (1918–2015)

Marco Cambiaghi

15.04.2019 | Review

Hereditary neuropathy with liability to pressure palsies

Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve …

Shahram Attarian, Farzad Fatehi, Yusuf A. Rajabally, Davide Pareyson

15.04.2019 | Original Communication

Motor, cognitive and behavioral differences in MDS PSP phenotypes

Progressive supranuclear palsy (PSP) is a rare, rapidly progressive, neurodegenerative disease linked to abnormal tau-protein accumulation and characterized by vertical supranuclear gaze palsy as well as postural instability with falls [ 1 ]. The …

Marina Picillo, Sofia Cuoco, Maria Francesca Tepedino, Arianna Cappiello, Giampiero Volpe, Roberto Erro, Gabriella Santangelo, Maria Teresa Pellecchia, Paolo Barone, The PSP Salerno study group

13.04.2019 | Original Communication

Occurrence of cerebral small vessel disease at diagnosis of MPO-ANCA-associated vasculitis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a primary vasculitic disease pathologically characterized by inflammation of the small and medium-sized vessels of the body [ 1 ]. More than ten types of neutrophil …

Hiroki Tani, Koji Nagai, Takafumi Hosokawa, Kenichiro Hata, Takuya Kotani, Shimon Ishida, Tohru Takeuchi, Shigeki Arawaka

12.04.2019 | Review

Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?

While the pathogenesis of Parkinson’s disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The inflammatory process in Parkinson’s disease …

Malvyne Rolli-Derkinderen, Laurène Leclair-Visonneau, Arnaud Bourreille, Emmanuel Coron, Michel Neunlist, Pascal Derkinderen

11.04.2019 | Retraction Note

Retraction Note to: Juvenile-onset myasthenia gravis: autoantibody status, clinical characteristics and genetic polymorphisms

The Joint Editors-in-Chief have retracted this article [1] at the request of the University of Bergen and the Norwegian Board of Health Supervision.

Yu Hong, Geir Olve Skeie, Paraskevi Zisimopoulou, Katerina Karagiorgou, Socrates J. Tzartos, Xiang Gao, Yao-Xian Yue, Fredrik Romi, Xu Zhang, Hai-Feng Li, Nils Erik Gilhus

10.04.2019 | Original Communication Open Access

Musical hallucinations and their relation with epilepsy

Musical hallucinations are poorly understood phenomena. Their relation with epilepsy was first described over a century ago, but never systematically explored. We, therefore, reviewed the literature, and assessed all descriptions of musical …

J. A. F. Coebergh, R. F. Lauw, I. E. C. Sommer, J. D. Blom

10.04.2019 | Letter to the Editors

Balanced sex distribution in patients with Menière’s disease

Sandra Becker-Bense, Constanze Wittmann, Marianne Dieterich

09.04.2019 | Original Communication

Risk of traffic accidents after onset of vestibular disease assessed with a surrogate marker

Driving restrictions have a deep impact on the quality of life of the affected patients [ 1 ]. Dizziness may lead to spatial disorientation, to a potential limitation of the ability to drive [ 2 , 3 ], and may, therefore, possibly increase the risk …

Doreen Huppert, Andreas Straube, Lucia Albers, Rüdiger von Kries, Viola Obermeier

09.04.2019 | Original Communication Open Access

Association between sleep disturbance in Alzheimer’s disease patients and burden on and health status of their caregivers

Alzheimer’s disease (AD) is the most common cause of dementia, affecting around 50 million people worldwide [ 1 ]. In Japan, the prevalence of AD in people aged 65 years or older is approximately 2% [ 2 ]. Symptoms of AD can be divided into core …

Shoki Okuda, Jumpei Tetsuka, Kenichi Takahashi, Yasuo Toda, Takekazu Kubo, Shigeru Tokita

09.04.2019 | Correction

Correction to: A cluster of disseminated small cortical lesions in MELAS: its distinctive clinical and neuroimaging features

The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading.

Yu Hongo, Juntaro Kaneko, Hiroki Suga, Daisuke Ishima, Eiji Kitamura, Tsugio Akutsu, Yuya Onozawa, Naomi Kanazawa, Tomohide Goto, Kazutoshi Nishiyama, Takahiro Iizuka

08.04.2019 | Original Communication Open Access

A novel COL6A2 mutation causing late-onset limb-girdle muscular dystrophy

Limb-girdle muscular dystrophies (LGMD) are genetic disorders characterized by weakness of predominantly proximal limb and trunk muscles due to progressive loss of muscle tissue. Collagen VI-related muscular dystrophies usually display more …

Manu Jokela, Sara Lehtinen, Johanna Palmio, Anna-Maija Saukkonen, Sanna Huovinen, Anna Vihola, Bjarne Udd

08.04.2019 | Original Communication

Amyloid PETs are commonly negative in suspected Alzheimer’s disease with an increase in CSF phosphorylated-tau protein concentration but an Aβ42 concentration in the very high range: a prospective study

The dual criterion of a brain increase in phosphorylated-tau (P-tau) proteins, combined with the presence of an amyloid deposition in the brain, was recently proposed by the National Institute on Aging and Alzheimer’s Association (NIA-AA) for the …

Chloé Manca, Thérèse Rivasseau Jonveaux, Véronique Roch, Pierre-Yves Marie, Gilles Karcher, Zohra Lamiral, Catherine Malaplate, Antoine Verger