Multiple randomized controlled trials have demonstrated the benefit of mechanical thrombectomy (MT) over medical therapy in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Yet, AIS continues to be a global leading …
verfasst von:
Michelle A. Toruno, Omar M. Al-Janabi, Shereif Ghozy, Hassan Kobeissi, Ramanathan Kadirvel, Alejandro A. Rabinstein, David F. Kallmes
Neuropsychiatric manifestations have been reported with prior coronavirus epidemics, namely severe acute respiratory syndrome (SARS-CoV) in 2002 and Middle East respiratory syndrome (MERS-CoV) in 2012 [ 1 – 4 ]. In December 2019, patients in the …
verfasst von:
Kapil Gururangan, Veronica J. Peschansky, Grace Van Hyfte, Parul Agarwal, Leah J. Blank, Brian Mathew, Jonathan Goldstein, Churl-Su Kwon, Louise McCarthy, Ariella Cohen, Andy Ho Wing Chan, Pojen Deng, Mandip Dhamoon, Eveline Gutzwiller, Qing Hao, Celestine He, Britany Klenofsky, Hernan Nicolas Lemus, Lara Marcuse, Allison Navis, Wilson D. Heredia Nunez, Mallory N. Luckey, Emily M. Schorr, Anuradha Singh, Gabriela B. Tantillo, Claire Ufongene, James J. Young, Priti Balchandani, Joanne R. Festa, Georges Naasan, Alexander W. Charney, Girish N. Nadkarni, Nathalie Jetté, for the Sinai NeuroCOVID-19 Study Group
Parkinson's disease (PD) is a prevalent neurodegenerative disorder [ 1 ] and is characterized by motor symptoms resulting from dopamine deficiency in the basal ganglia [ 2 ] and non-motor manifestations [ 3 , 4 ], such as sleep disturbances [ 5 , 6 …], cognitive impairment [
Several new treatment options with improved side effect profiles compared to conventional chemotherapeutics for neurological autoimmune disorders, such as multiple sclerosis, but also for rare neuromuscular disorders, such as myasthenia gravis …
verfasst von:
Felix Kohle, Gilbert Wunderlich, Gereon R. Fink, Michael Schroeter, Helmar C. Lehmann, Christian Schneider
Alzheimer's disease (AD) is the most common form of dementia and also the predominant type of neurodegenerative disease [ 1 , 2 ]. The characteristics of AD include progressive cognitive impairment and behavioral disturbances, significantly …
Joana Fonte, Andrea Stabile, Marco de Curtis, Roberta Di Giacomo, Chiara Pastori, Giuseppe Didato, Francesca Andreetta, Angelo Del Sole, Fabio Doniselli, Francesco Deleo
Multiple sclerosis (MS) is the most frequent demyelinating and neurodegenerative disease of the central nervous system in young adults [ 1 ]. Due to the unpredictable nature of symptoms in MS in terms of their frequency, severity, and trajectory …
verfasst von:
Ilse M. Nauta, Maureen van Dam, Dirk Bertens, Roy P. C. Kessels, Luciano Fasotti, Bernard M. J. Uitdehaag, Anne E. M. Speckens, Brigit A. de Jong
Asymmetry of motor symptoms is characteristic for Parkinson’s disease (PD) and is particularly observed in the early disease stages. However, asymmetry of symptoms is thought to persist during the entire course of the disease, even if to a lesser …
verfasst von:
Jana Seuthe, Helen Hermanns, Femke Hulzinga, Nicholas D’Cruz, Günther Deuschl, Pieter Ginis, Alice Nieuwboer, Christian Schlenstedt
Ocrelizumab (OCR) is a humanized monoclonal antibody that selectively targets CD20+ B cells. It is approved for the treatment of relapsing multiple sclerosis (MS) and primary progressive MS [ 1 , 2 ]. In the pivotal phase 3 trials of OCR (OPERA I …
verfasst von:
Hans-Peter Hartung, Thomas Berger, Robert A. Bermel, Bruno Brochet, William M. Carroll, Trygve Holmøy, Rana Karabudak, Joep Killestein, Carlos Nos, Francesco Patti, Amy Perrin Ross, Ludo Vanopdenbosch, Timothy Vollmer, Regine Buffels, Monika Garas, Karen Kadner, Marianna Manfrini, Qing Wang, Mark S. Freedman
Amyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status and progression has led to investigations that …
verfasst von:
Elena Niccolai, Matteo Pedone, Ilaria Martinelli, Giulia Nannini, Simone Baldi, Cecilia Simonini, Leandro Di Gloria, Elisabetta Zucchi, Matteo Ramazzotti, Pietro Giorgio Spezia, Fabrizio Maggi, Gianluca Quaranta, Luca Masucci, Gianluca Bartolucci, Francesco Claudio Stingo, Jessica Mandrioli, Amedeo Amedei
The prevalence of all-cause dementia increases exponentially from ages 65 to 85, doubling every 5 years [ 1 , 2 ], and continues to increase even after the age of 90 [ 3 ]. In a recent epidemiological study conducted in the province of Modena …
Spontaneous intracranial hypotension (SIH) is an underdiagnosed disease caused by spinal CSF leaks, manifesting at any age [ 1 ]. The annual incidence rate of 4–5/100,000 is estimated [ 2 – 4 ]. Typically, clinical manifestation entails, but is not …
verfasst von:
Katharina Wolf, Florian Volz, Niklas Lützen, Hansjoerg Mast, Marco Reisert, Amir El Rahal, Christian Fung, Mukesch J. Shah, Jürgen Beck, Horst Urbach
Progressive supranuclear palsy (PSP) is a 4-repeat (4R) tauopathy that may present with a variety of cognitive, motor, and behavioral symptoms [ 39 ]. PSP can present clinically with several variants, including but not limited to the classic …
verfasst von:
Jack A. Black, Nha Trang Thu Pham, Farwa Ali, Mary M. Machulda, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and degenerative CNS disease [ 1 ]. Pathological changes are fuelled by the activation of circulating and CNS resident immune cells [ 2 ]. T, B and natural killer lymphocytes …
verfasst von:
Antonio Luca Spiezia, Giulia Scalia, Maria Petracca, Daniele Caliendo, Marcello Moccia, Antonia Fiore, Vincenza Cerbone, Roberta Lanzillo, Vincenzo Brescia Morra, Antonio Carotenuto
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated inflammatory disease of the central nervous system (CNS) that often affects the optic nerves, spinal cord, and brainstem, including the area postrema (AP) [ 1 , 2 ]. The majority …
verfasst von:
Claudia Pestchanker, Brenda Bertado Cortez, Marco A. Lana Peixoto, José Ignacio Gortari, Sheila Castro Suarez, Cesar Caparo Zamalloa, Graciana Galiana, Francisco Peñalver, Vanesa Daccach Marques, Katharina Messias, Lorna Galleguillos, Fernando García, Juan I. Rojas, Liliana Patrucco, Edgardo Cristiano, Verónica Tkachuk, Susana Liwacki, Jorge Correale, Mariano Marrodan, María C. Ysraelit, Carlos Vrech, Norma Deri, Felisa Leguizamon, Darío Tavolini, Carolina Mainella, Gisela Zanga, Marina Alonso Serena, Ethel Ciampi, Herval Ribeiro Soares Neto, Pablo Lopez, Edgar Carnero Contentti
Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder caused by mutations in the gene encoding for dystrophin, a protein expressed in the sarcolemma of the skeletal and cardiac muscles. Lack of dystrophin affects the …
verfasst von:
Lisa Wahlgren, Anna-Karin Kroksmark, Anders Lindblad, Mar Tulinius, Kalliopi Sofou
Multiple sclerosis (MS) is a chronic, degenerative, and often progressive disease of the central nervous system that can affect multiple parts of the body and result in various symptoms including mobility restrictions, fatigue, pain, depression …
verfasst von:
Julian Hirt, Kinga Dembowska, Tim Woelfle, Cathrine Axfors, Cristina Granziera, Jens Kuhle, Ludwig Kappos, Lars G. Hemkens, Perrine Janiaud
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. It is mostly sporadic, with the C9orf72 repeat expansion being the most common genetic cause. While the prevalence of C9orf72-ALS in patients from different …
A ponto-cerebello-thalamo-cortical network is the pathophysiological correlate of primary orthostatic tremor. Affected patients often do not respond satisfactorily to pharmacological treatment. Consequently, the objective of the current study was …
verfasst von:
Florian Schoeberl, James Dowsett, Cauchy Pradhan, Denis Grabova, Angelina Köhler, Paul Taylor, Andreas Zwergal
