Journal of Neurology OnlineFirst articles

04.05.2024 | Letter to the Editors

Cerebellar encephalitis and peripheral neuropathy with an atypical clinical and neuroimaging signature following Covid-19 vaccine: a report of two cases

verfasst von:: Marin Sicard, Natalia Shor, Vincent Davy, Jean-Jacques Rouby, Bruno Oquendo, Thierry Maisonobe, Louis Puybasset, Stephane Lehericy, Amandine Lecarpentier, Cristiano Donadio, Christel Oasi, Joël Belmin, Catherine Lubetzki, Jean-Christophe Corvol, David Grabli, Dario Saracino

03.05.2024 | Original Communication

Is there a spinal tap responder in progressive supranuclear palsy? The first prospective study

Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disease that is characterized by supranuclear gaze palsy, akinetic rigidity, gait disturbance, and dementia [ 1 ]. PSP presents with various clinical phenotypes that mimic …

verfasst von:: Masahiro Ohara, Takaaki Hattori, Qingmeng Chen, Kaoru Shimano, Kosei Hirata, Mie Matsui, Takanori Yokota

Open Access 03.05.2024 | Original Communication

Evaluation of a multimodal diagnostic algorithm for prediction of cognitive impairment in elderly patients with dizziness

Current classifications of vestibular disorders almost exclusively list peripheral neuro-otological disorders such as bilateral vestibulopathy as a cause of chronic dizziness [ 1 , 2 ], while central or higher vestibular network pathologies are …

verfasst von:: K. Felfela, N. Jooshani, K. Möhwald, D. Huppert, S. Becker-Bense, F. Schöberl, R. Schniepp, F. Filippopulos, M. Dieterich, M. Wuehr, A. Zwergal

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Open Access 02.05.2024 | Original Communication

Gait and heart rate: do they measure trait or state physical fatigue in people with multiple sclerosis?

Fatigue is a hallmark symptom of multiple sclerosis (MS) and affects a significant majority of people with MS (pwMS) [ 1 , 2 ]. About half of pwMS consider fatigue to be their most debilitating issue [ 3 ]. Fatigue in MS is associated with disease …

verfasst von:: Irina Galperin, David Buzaglo, Eran Gazit, Nathaniel Shimoni, Raz Tamir, Keren Regev, Arnon Karni, Jeffrey M. Hausdorff

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01.05.2024 | Review

Advanced neuroimaging techniques to explore the effects of motor and cognitive rehabilitation in multiple sclerosis

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) [ 1 ]. MS is a multifaceted disease arising from complex gene–environment interactions [ 1 ], affecting …

verfasst von:: Maria A. Rocca, Francesco Romanò, Nicolò Tedone, Massimo Filippi

01.05.2024 | Original Communication

Large phenotypic diversity by genotype in patients with GNE myopathy: 10 years after the establishment of a national registry in Japan

GNE myopathy is an autosomal recessive distal myopathy caused by pathogenic variants in the GNE gene, which encodes the bifunctional enzyme uridine diphosphate-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK kinase) …

verfasst von:: Wakako Yoshioka, Harumasa Nakamura, Mari Oba, Yoshihiko Saito, Ichizo Nishino, Madoka Mori-Yoshimura

Open Access 30.04.2024 | Review

Management of multiple sclerosis in older adults: review of current evidence and future perspectives

Multiple sclerosis (MS) is a chronic central nervous system (CNS) autoimmune disorder with clinical onset typically in young adults ages 20–40. As the world’s population ages and survival increases, there is an increasing number of older adults …

verfasst von:: Kimberly A. DiMauro, Carol Swetlik, Jeffrey A. Cohen

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Open Access 29.04.2024 | Original Communication

Diagnostic value of neurofilaments in differentiating motor neuron disease from multifocal motor neuropathy

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron (MN) loss in the primary motor cortex, brainstem, and spinal cord. Patients typically suffer from progressive weakness of voluntary muscles due …

verfasst von:: Camilla Wohnrade, Tabea Seeliger, Stefan Gingele, Bogdan Bjelica, Thomas Skripuletz, Susanne Petri

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27.04.2024 | Original Communication

Chronic basilar artery occlusion: a retrospective monocentric study

Basilar artery occlusions account for only 1% of all strokes [ 1 ]. Acute basilar artery occlusions regularly cause devastating strokes with a high mortality and morbidity rate [ 1 , 2 ]. Overall outcomes are very poor and can only be improved if …

verfasst von:: Christian Roth, Rosa Yavuz, Carolin Maschita, Andreas Ferbert, Johannes Matthaei

27.04.2024 | Original Communication

Traumatic brain injury incidence and mortality: a large population-based study

Traumatic brain injury (TBI) is a severe condition that represents a major global public health concern, affecting millions of individuals worldwide, and causing substantial health burdens and socioeconomic implications. In 2016 about 27 million …

verfasst von:: Claudio Barbiellini Amidei, Laura Salmaso, Ugo Fedeli, Mario Saia

Open Access 26.04.2024 | Original Communication

Association of serum glial fibrillary acidic protein with progression independent of relapse activity in multiple sclerosis

Multiple sclerosis (MS) is an immune-mediated disease in which both the adaptive and innate immune systems play an important role. The adaptive immune system is often associated with clinical relapses and the formation of focal inflammatory …

verfasst von:: Igal Rosenstein, Anna Nordin, Hemin Sabir, Clas Malmeström, Kaj Blennow, Markus Axelsson, Lenka Novakova

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24.04.2024 | Original Communication

Outcomes of mechanical thrombectomy in patients with acute ischemic stroke and thrombocytopenia: systematic review and meta-analysis

Multiple randomized controlled trials have demonstrated the benefit of mechanical thrombectomy (MT) over medical therapy in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). Yet, AIS continues to be a global leading …

verfasst von:: Michelle A. Toruno, Omar M. Al-Janabi, Shereif Ghozy, Hassan Kobeissi, Ramanathan Kadirvel, Alejandro A. Rabinstein, David F. Kallmes

24.04.2024 | Original Communication

Neuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study

Neuropsychiatric manifestations have been reported with prior coronavirus epidemics, namely severe acute respiratory syndrome (SARS-CoV) in 2002 and Middle East respiratory syndrome (MERS-CoV) in 2012 [ 1 – 4 ]. In December 2019, patients in the …

verfasst von:: Kapil Gururangan, Veronica J. Peschansky, Grace Van Hyfte, Parul Agarwal, Leah J. Blank, Brian Mathew, Jonathan Goldstein, Churl-Su Kwon, Louise McCarthy, Ariella Cohen, Andy Ho Wing Chan, Pojen Deng, Mandip Dhamoon, Eveline Gutzwiller, Qing Hao, Celestine He, Britany Klenofsky, Hernan Nicolas Lemus, Lara Marcuse, Allison Navis, Wilson D. Heredia Nunez, Mallory N. Luckey, Emily M. Schorr, Anuradha Singh, Gabriela B. Tantillo, Claire Ufongene, James J. Young, Priti Balchandani, Joanne R. Festa, Georges Naasan, Alexander W. Charney, Girish N. Nadkarni, Nathalie Jetté, for the Sinai NeuroCOVID-19 Study Group

24.04.2024 | Original Communication

GBA moderates cognitive reserve's effect on cognitive function in patients with Parkinson's disease

Parkinson's disease (PD) is a prevalent neurodegenerative disorder [ 1 ] and is characterized by motor symptoms resulting from dopamine deficiency in the basal ganglia [ 2 ] and non-motor manifestations [ 3 , 4 ], such as sleep disturbances [ 5 , 6 …], cognitive impairment [

verfasst von:: Chia-Wen Chang, Chun-Hsiang Tan, Wei-Pin Hong, Rwei-Ling Yu

24.04.2024 | Pioneers in Neurology

Rafael Lorente de Nó (1902–1990)

verfasst von:: Juan Manuel Espinosa-Sanchez, Nicolas Perez-Fernandez, Angel Batuecas-Caletrio

Open Access 24.04.2024 | Original Communication

Rituximab in non-systemic vasculitic neuropathy: a single-center experience

Several new treatment options with improved side effect profiles compared to conventional chemotherapeutics for neurological autoimmune disorders, such as multiple sclerosis, but also for rare neuromuscular disorders, such as myasthenia gravis …

verfasst von:: Felix Kohle, Gilbert Wunderlich, Gereon R. Fink, Michael Schroeter, Helmar C. Lehmann, Christian Schneider

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24.04.2024 | Review

Sleep characteristics and risk of Alzheimer’s disease: a systematic review and meta-analysis of longitudinal studies

Alzheimer's disease (AD) is the most common form of dementia and also the predominant type of neurodegenerative disease [ 1 , 2 ]. The characteristics of AD include progressive cognitive impairment and behavioral disturbances, significantly …

verfasst von:: Shichan Wang, Xiaoting Zheng, Jingxuan Huang, Jiyong Liu, Chunyu Li, Huifang Shang

24.04.2024 | Letter to the Editors

Seizures in autoimmune-associated epilepsy: a long-term video-EEG monitoring study

verfasst von:: Joana Fonte, Andrea Stabile, Marco de Curtis, Roberta Di Giacomo, Chiara Pastori, Giuseppe Didato, Francesca Andreetta, Angelo Del Sole, Fabio Doniselli, Francesco Deleo

Open Access 23.04.2024 | Original Communication

Improved quality of life and psychological symptoms following mindfulness and cognitive rehabilitation in multiple sclerosis and their mediating role for cognition: a randomized controlled trial

Multiple sclerosis (MS) is the most frequent demyelinating and neurodegenerative disease of the central nervous system in young adults [ 1 ]. Due to the unpredictable nature of symptoms in MS in terms of their frequency, severity, and trajectory …

verfasst von:: Ilse M. Nauta, Maureen van Dam, Dirk Bertens, Roy P. C. Kessels, Luciano Fasotti, Bernard M. J. Uitdehaag, Anne E. M. Speckens, Brigit A. de Jong

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Open Access 23.04.2024 | Original Communication

Gait asymmetry and symptom laterality in Parkinson’s disease: two of a kind?

Asymmetry of motor symptoms is characteristic for Parkinson’s disease (PD) and is particularly observed in the early disease stages. However, asymmetry of symptoms is thought to persist during the entire course of the disease, even if to a lesser …

verfasst von:: Jana Seuthe, Helen Hermanns, Femke Hulzinga, Nicholas D’Cruz, Günther Deuschl, Pieter Ginis, Alice Nieuwboer, Christian Schlenstedt

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Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

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