Background
Methods
Data sources
MG patients
Study population
Outcome variables
Co-variables
Statistical analysis
Myasthenia gravis, n = 330 | Matched references; n = 6600 | |
---|---|---|
Characteristics | ||
Age, m (sd) | 42.7 (13.0) | 42.7 (13.0) |
Male, n (%) | 130 (39.4) | 2600 (39.4) |
Profession, n (%) | ||
Employer/director | 31 (9.4) | 620 (9.4) |
Employee | 240 (72.7) | 4800 (72.7) |
Not employed | 57 (17.3) | 1140 (17.3) |
Pension/early retirement | 2 (0.6) | 40 (0.6) |
Marital status, n (%) | ||
Married/registered partnership | 197 (59.7) | 3712 (56.2) |
Not married/registered partnership | 130 (39.4) | 2885 (43.7) |
Missing | 3 (0.9) | 3 (<0.1) |
Pharmacological treatment, n (%) | ||
AChEI | 158 (47.9) | – |
AChEI+ | 172 (52.1) | – |
Prior sick leave (1 year), n (%) | ||
0 weeks | 190 (57.6) | 5851 (88.7) |
1–8 weeks | 80 (24.2) | 477 (7.2) |
9–52 weeks | 60 (18.2) | 272 (4.1) |
Time period | ||
1/1 1997–1/6 2008 | 249 (75.5) | 4980 (75.5) |
2/6 2008–31/12 2011 | 81 (24.6) | 1620 (24.6) |
Results
No LMP, n (%) | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a | |
---|---|---|---|
Comparison groups | No LMP, 1 year after diagnosis/match | ||
MG vs. matched references | 35 (10.6)/309 (4.7) | 2.42 (1.67–3.49) | 2.23 (1.46–3.38) |
MG: age 40+ vs. 18–39 | 22 (11.2)/13 (9.7) | 1.18 (0.57–2.43) | 2.02 (0.84–4.86) |
MG: male vs. female | 10 (7.7)/25 (12.5) | 0.58 (0.27–1.26) | 0.67 (0.28–1.59) |
MG: AChEI+ vs. AChEI | 21 (12.2)/14 (8.9) | 1.43 (0.70–2.92) | 1.26 (0.57–2.78) |
Comparison groups | No LMP, 2 years after diagnosis/match | ||
MG vs. matched references | 75 (22.7)/327 (5.0) | 5.64 (4.26–7.47) | 5.76 (4.13–8.04) |
MG: age 40+ vs. 18–39 | 44 (22.5)/31 (23.1) | 0.96 (0.57–1.62) | 1.21 (0.64–2.27) |
MG: male vs. female | 19 (14.6)/56 (28.0) | 0.44 (0.25–0.78) | 0.39 (0.20–0.74) |
MG: AChEI+ vs. AChEI | 49 (28.5)/26 (16.5) | 2.02 (1.18–3.45) | 1.95 (1.09–3.50) |
≥9 weeks, n (%) | Unadjusted OR (95% CI) | Adjusted OR (95% CI)a | |
---|---|---|---|
Comparison groups | ≥9 weeks sick leave, 1 year after diagnosis/match | ||
MG vs. matched references | 136 (41.2)/225 (3.4) | 19.86 (15.37–25.67) | 14.80 (10.97–19.95) |
MG: age 40+ vs. 18–39 | 84 (42.9)/52 (38.8) | 1.18 (0.76–1.85) | 1.25 (0.70–2.24) |
MG: male vs. female | 50 (38.5)/86 (43.0) | 0.83 (0.53–1.30) | 0.66 (0.38–1.15) |
MG: AChEI+ vs. AChEI | 76 (44.2)/60 (38.0) | 1.29 (0.83–2.01) | 1.17 (0.70–1.96) |
Comparison groups | ≥9 weeks sick leave, 2 years after diagnosis/match | ||
MG vs. matched references | 155 (47.0)/448 (6.8) | 12.16 (9.60–15.41) | 8.60 (6.60–11.23) |
MG: age 40+ vs. 18–39 | 94 (48.0)/61 (45.5) | 1.10 (0.71–1.71) | 1.34 (0.76–2.36) |
MG: male vs. female | 53 (40.8)/102 (51.0) | 0.66 (0.42–1.0) | 0.50 (0.29–0.86) |
MG: AChEI+ vs. AChEI | 91 (52.9)/64 (40.5) | 1.65 (1.07–2.55) | 1.61 (0.98–2.64) |