Erschienen in:
01.07.2003 | Original Article
Lack of association of tumor necrosis factor alpha gene polymorphism in patients with rheumatoid arthritis in central Taiwan
verfasst von:
Sui-Foo Lo, Chung-Ming Huang, Mei-Chen Wu, Jer-Yuarn Wu, Fuu-Jen Tsai
Erschienen in:
Rheumatology International
|
Ausgabe 4/2003
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Abstract.
The aim of this study was to investigate the association of tumor necrosis factor alpha (TNFα) gene promoter polymorphisms in Chinese patients with rheumatoid arthritis (RA) in central Taiwan. A total of 106 RA patients and 253 normal controls were studied. Polymerase chain reaction (PCR)-based restriction analysis was used to identify A/G polymorphism at position 308 in the promoter region of the TNFα, which is located at 6q21.3. For the genotype of TNFα-308 polymorphism, there was no statistically significant difference between RA patients and normal controls (Fisher's exact test, P=0.82). Additionally, no statistical association in the distribution of TNFα-308 polymorphism between rheumatoid factor (RF)-positive and -negative patients was noted. The lack of an association of TNFα-308 polymorphism with RA and RF in our study implies that TNFα-308 polymorphism cannot serve as a candidate gene marker for screening RA patients in Taiwan.