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19.11.2018 | Basic Science • Short Communication

Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus

verfasst von: Chutintorn Sriphrapradang, Sittichai Pinyopodjanard, Onnicha Suntornlohanakul, Hataikarn Nimitphong, Naricha Chirakalwasan, Sunee Saetang, Thunyarat Anothaisintawee, Nantaporn Siwasaranond, Areesa Manodpitipong, La-Or Chailurkit, Sirimon Reutrakul

Erschienen in: Sleep and Breathing | Ausgabe 3/2019

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Abstract

Purpose

Hypothyroidism is associated with a high frequency of obstructive sleep apnea (OSA). However, the prevalence of OSA in hypothyroid patients is not different from the general population in many reports. The importance of thyroid function screening in sleep-disordered breathing is still controversial. This study aimed to explore the association between thyroid dysfunction and OSA in the adults with prediabetes or diabetes mellitus type 2, who have very high prevalence of OSA.

Methods

OSA was assessed using an in-home monitoring device, WatchPAT200. OSA severity was measured using apnea-hypopnea index (AHI), oxygen desaturation index (ODI), minimum oxygen saturation (minO2), and time spent under oxygen saturation < 90% (T90). Patients with pre-existing thyroid dysfunction were excluded.

Results

Participants included 70 men and 118 women with mean age 52.8 ± 10.9 years and body mass index 28.2 ± 4.9 kg/m². One hundred forty participants (75%) had OSA, with a median AHI of 10.1 (interquartile range 4.8, 18.3). The percentage of positive thyroid autoantibody (thyroperoxidase and thyroglobulin antibody) was similar among the subjects with and without OSA. There was no correlation between the levels of thyroid function (TSH, FT3, FT4, TSH/FT3, and TSH/FT4 ratio) and the severity indices of OSA (AHI, ODI, minO2, and T90).

Conclusions

These data do not support universal screening for thyroid dysfunction in OSA patients with diabetes or prediabetes.

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Titel: Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus
verfasst von: Chutintorn Sriphrapradang
Sittichai Pinyopodjanard
Onnicha Suntornlohanakul
Hataikarn Nimitphong
Naricha Chirakalwasan
Sunee Saetang
Thunyarat Anothaisintawee
Nantaporn Siwasaranond
Areesa Manodpitipong
La-Or Chailurkit
Sirimon Reutrakul
Publikationsdatum: 19.11.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1756-x

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Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus

Abstract

Purpose

Methods

Results

Conclusions

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