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Journal of Natural Medicines

Erschienen in:

31.01.2019 | Note

Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

verfasst von: Kazumi Sagayama, Naonobu Tanaka, Takatoshi Fukumoto, Yoshiki Kashiwada

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2019

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Abstract

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1–5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

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Titel: Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells
verfasst von: Kazumi Sagayama
Naonobu Tanaka
Takatoshi Fukumoto
Yoshiki Kashiwada
Publikationsdatum: 31.01.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01280-0

Springer Medizin

Abstract

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