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Osteoporosis International

Erschienen in:

01.03.2015 | Original Article

Length of sick leave as a risk marker of hip fracture: a nationwide cohort study from Sweden

verfasst von: S. Stenholm, J. Vahtera, L. Kjeldgård, M. Kivimäki, K. Alexanderson

Erschienen in: Osteoporosis International | Ausgabe 3/2015

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Abstract

Summary

Sickness absence is a risk marker for future health outcomes, but no previous studies have examined its association with osteoporotic fractures in old age. The results of this prospective population-based cohort study based on Swedish registers suggest that sickness absence is associated with higher risk of hip fracture.

Introduction

Number of sick leave days is a risk marker for future health outcomes, but few studies have examined its association with major public health concerns in old age, such as osteoporotic fractures. The aim of this prospective, nationwide, population-based cohort study based on Swedish registers was to investigate the association between number of sick leave days and future risk of hip fracture.

Methods

Participants included were all 983,244 individuals who were living in Sweden on 31 December 1995, aged 50 to 64 years, employed, and with no previous hip fracture. Those with sick leave days in 1995 were compared to those with no sickness absence. Incidence of hip fracture was followed from 1996 to 2010.

Results

According to Cox regression models adjusted for sociodemographic factors and morbidity, being on sick leave more than 3 months, irrespective of cause, was associated with a 2.0-fold (hazard ratio (HR) 1.96, 95 % confidence interval (CI) 1.74–2.20) and 1.4-fold (HR 1.40, 95 % CI 1.27–1.56) increased risk of hip fracture in men and women, respectively. Analyses repeated among those with previous non-hip fractures replicated the significant associations.

Conclusion

This nationwide cohort study suggests that sickness absence in working-age women and men is a risk marker of hip fracture at old ages.

Nur mit Berechtigung zugänglich

Marmot M, Feeney A, Shipley M, North F, Syme SL (1995) Sickness absence as a measure of health status and functioning: from the UK Whitehall II study. J Epidemiol Community Health 49(2):124–130CrossRefPubMedCentralPubMed

Kivimäki M, Head J, Ferrie JE, Shipley MJ, Vahtera J, Marmot MG (2003) Sickness absence as a global measure of health: evidence from mortality in the Whitehall II prospective cohort study. BMJ 327((7411):364. doi:10.1136/bmj.327.7411.364 CrossRefPubMedCentralPubMed

Alexanderson K, Norlund A (2004) Swedish Council on Technology Assessment in Health Care (SBU). Chapter 1. Aim, background, key concepts, regulations, and current statistics. . Scand J Public Health 32 (Supplement 63):12–30

Vahtera J, Westerlund H, Ferrie JE, Head J, Melchior M, Singh-Manoux A, Zins M, Goldberg M, Alexanderson K, Kivimäki M (2010) All-cause and diagnosis-specific sickness absence as a predictor of sustained suboptimal health: a 14-year follow-up in the GAZEL cohort. J Epidemiol Community Health 64(4):311–317. doi:10.1136/jech.2008.083923 CrossRefPubMedCentralPubMed

Kivimaki M, Forma P, Wikstrom J, Halmeenmaki T, Pentti J, Elovainio M, Vahtera J (2004) Sickness absence as a risk marker of future disability pension: the 10-town study. J Epidemiol Community Health 58(8):710––711. doi:10.1136/jech.2003.015842 CrossRefPubMedCentralPubMed

Lund T, Kivimaki M, Labriola M, Villadsen E, Christensen KB (2008) Using administrative sickness absence data as a marker of future disability pension: the prospective DREAM study of Danish private sector employees. Occup Environ Med 65(1):28–31CrossRefPubMed

Labriola M, Lund T (2007) Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990–2004. Int J Med Sci 4(3):153–158CrossRefPubMedCentralPubMed

Vahtera J, Pentti J, Kivimaki M (2004) Sickness absence as a predictor of mortality among male and female employees. J Epidemiol Community Health 58(4):321–326CrossRefPubMedCentralPubMed

Ferrie JE, Vahtera J, Kivimaki M, Westerlund H, Melchior M, Alexanderson K, Head J, Chevalier A, Leclerc A, Zins M, Goldberg M, Singh-Manoux A (2009) Diagnosis-specific sickness absence and all-cause mortality in the GAZEL study. J Epidemiol Community Health 63((1):50–55. doi:10.1136/jech.2008.074369 CrossRefPubMedCentralPubMed

10.

Head J, Ferrie JE, Alexanderson K, Westerlund H, Vahtera J, Kivimaki M (2008) Diagnosis-specific sickness absence as a predictor of mortality: the Whitehall II prospective cohort study. BMJ 337:a1469CrossRefPubMedCentralPubMed

11.

Jansson C, Mittendorfer-Rutz E, Alexanderson K (2012) Sickness absence because of musculoskeletal diagnoses and risk of all-cause and cause-specific mortality: a nationwide Swedish cohort study. Pain 153(5):998–1005. doi:10.1016/j.pain.2012.01.028 CrossRefPubMed

12.

Vingård E, Alexanderson K, Norlund A (2004) Swedish Council on Technology Assessment in Health Care (SBU). Chapter 9. Consequences of being on sick leave. Scandinavian Journal of Public Health 32(Supplemet 63, Review):207–215

13.

Floderus B, Goransson S, Alexanderson K, Aronsson G (2005) Self-estimated life situation in patients on long-term sick leave. J Rehabil Med 37((5):291–299. doi:10.1080/16501970510034422 CrossRefPubMed

14.

Kivimaki M, Head J, Ferrie JE, Singh-Manoux A, Westerlund H, Vahtera J, Leclerc A, Melchior M, Chevalier A, Alexanderson K, Zins M, Goldberg M (2008) Sickness absence as a prognostic marker for common chronic conditions: analysis of mortality in the GAZEL study. Occup Environ Med 65((12):820–826. doi:10.1136/oem.2007.038398 CrossRefPubMedCentralPubMed

15.

Compston J (2004) Action plan for the prevention of osteoporotic fractures in the European Community. Osteoporos Int 15(4):259–262CrossRefPubMed

16.

Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353(9156):878–882CrossRef

17.

Omsland TK, Emaus N, Tell GS, Magnus JH, Ahmed LA, Holvik K, Center J, Forsmo S, Gjesdal CG, Schei B, Vestergaard P, Eisman JA, Falch JA, Tverdal A, Sogaard AJ, Meyer HE (2014) Mortality following the first hip fracture in Norwegian women and men (1999–2008). A NOREPOS study, Bone

18.

Todd CJ, Palmer C, Camilleri-Ferrante C, Freeman CJ, Laxton CE, Parker MJ, Payne BV, Rushton N (1995) Differences in mortality after fracture of hip. BMJ 311(7011):1025CrossRefPubMedCentralPubMed

19.

Johnell O, Kanis JA, Oden A, Sernbo I, Redlund-Johnell I, Petterson C, De Laet C, Jonsson B (2004) Mortality after osteoporotic fractures. Osteoporos Int 15(1):38–42CrossRefPubMed

20.

Haentjens P, Autier P, Barette M, Boonen S (2001) The economic cost of hip fractures among elderly women. A one-year, prospective, observational cohort study with matched-pair analysis. Belgian Hip Fracture Study Group J Bone Joint Surg Am 83-A(4):493–500

21.

Haentjens P, Lamraski G, Boonen S (2005) Costs and consequences of hip fracture occurrence in old age: an economic perspective. Disabil Rehabil 27(18–19):1129–1141CrossRefPubMed

22.

Magaziner J, Fredman L, Hawkes W, Hebel JR, Zimmerman S, Orwig DL, Wehren L (2003) Changes in functional status attributable to hip fracture: a comparison of hip fracture patients to community-dwelling aged. Am J Epidemiol 157(11):1023–1031CrossRefPubMed

23.

Randell AG, Nguyen TV, Bhalerao N, Silverman SL, Sambrook PN, Eisman JA (2000) Deterioration in quality of life following hip fracture: a prospective study. Osteoporos Int 11(5):460–466CrossRefPubMed

24.

Boonen S, Autier P, Barette M, Vanderschueren D, Lips P, Haentjens P (2004) Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled study. Osteoporos Int 15(2):87–94CrossRefPubMed

25.

Ismail AA, Cockerill W, Cooper C, Finn JD, Abendroth K, Parisi G, Banzer D, Benevolenskaya LI, Bhalla AK, Armas JB, Cannata JB, Delmas PD, Dequeker J, Dilsen G, Eastell R, Ershova O, Falch JA, Felsch B, Havelka S, Hoszowski K, Jajic I, Kragl U, Johnell O, Lopez Vaz A, Lorenc R, Lyritis G, Marchand F, Masaryk P, Matthis C, Miazgowski T, Pols HA, Poor G, Rapado A, Raspe HH, Reid DM, Reisinger W, Janott J, Scheidt-Nave C, Stepan J, Todd C, Weber K, Woolf AD, Ambrecht G, Gowin W, Felsenberg D, Lunt M, Kanis JA, Reeve J, Silman AJ, O′Neill TW (2001) Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study. Osteoporos Int 12(2):85–90CrossRefPubMed

26.

Mallmin H, Ljunghall S, Persson I, Naessen T, Krusemo UB, Bergstrom R (1993) Fracture of the distal forearm as a forecaster of subsequent hip fracture: a population-based cohort study with 24 years of follow-up. Calcif Tissue Int 52(4):269–272CrossRefPubMed

27.

Haentjens P, Autier P, Collins J, Velkeniers B, Vanderschueren D, Boonen S (2003) Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women. A meta-analysis. J Bone Joint Surg Am 85-A(10):1936–1943PubMed

28.

Feeney A, North F, Head J, Canner R, Marmot M (1998) Socioeconomic and sex differentials in reason for sickness absence from the Whitehall II Study. Occup Environ Med 55(2):91–98CrossRefPubMedCentralPubMed

29.

Bekker MH, Rutte CG, van Rijswijk K (2009) Sickness absence: a gender-focused review. Psychol Health Med 14(4):405–418. doi:10.1080/13548500903012830 CrossRefPubMed

30.

Requena G, Abbing-Karahagopian V, Huerta C, De Bruin ML, Alvarez Y, Miret M, Hesse U, Gardarsdottir H, Souverein PC, Slattery J, Schneider C, Rottenkolber M, Schmiedl S, Gil M, De Groot MC, Bate A, Ruigómez A, García Rodríguez LA, Johansson S, de Vries F, Montero D, Schlienger R, Reynolds R, Klungel OH, de Abajo FJ (2014) Incidence rates and trends of hip/femur fractures in five European countries: comparison using E-Healthcare records databases. Calcif Tissue Int 94(6):580–589. doi:10.1007/s00223-014-9850-y

31.

Allolio B (1999) Risk factors for hip fracture not related to bone mass and their therapeutic implications. Osteoporos Int 9 Suppl 2(2):S9–S16CrossRef

32.

Marks R (2010) Hip fracture epidemiological trends, outcomes, and risk factors, 1970–2009. Int J Gen CXXMed 3:1–17

33.

Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332(12):767–773CrossRefPubMed

34.

Holmberg AH, Johnell O, Nilsson PM, Nilsson JA, Berglund G, Akesson K (2005) Risk factors for hip fractures in a middle-aged population: a study of 33,000 men and women. Osteoporos Int 16(12):2185–2194CrossRefPubMed

35.

Gerber Y, Melton LJ, McNallan SM, Jiang R, Weston SA, Roger VL (2013) Cardiovascular and noncardiovascular disease associations with hip fractures. Am J Med 26((2):169 e–119-126

36.

Li L, Setoguchi S, Cabral H, Jick S (2013) Opioid use for noncancer pain and risk of fracture in adults: a nested case-control study using the general practice research database. Am J Epidemiol 178(4):559–569CrossRefPubMed

37.

Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R (2012) Medication-related falls in the elderly: causative factors and preventive strategies. Drugs Aging 29(5):359–376CrossRefPubMed

38.

Causes of Death 2009 (2011). National Board of Health and Welfare Sweden, Stockholm

39.

Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, Heurgren M, Olausson PO (2011) External review and validation of the Swedish national inpatient register. BMC Public Health 11:450. doi:10.1186/1471-2458-11-450 CrossRefPubMedCentralPubMed

Titel: Length of sick leave as a risk marker of hip fracture: a nationwide cohort study from Sweden
verfasst von: S. Stenholm
J. Vahtera
L. Kjeldgård
M. Kivimäki
K. Alexanderson
Publikationsdatum: 01.03.2015
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 3/2015
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2985-x

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Abstract

Summary

Introduction

Methods

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