Erschienen in:
01.05.2015 | Research Commentary
Letter regarding Li JS et al. entitled “ERCC polymorphisms and prognosis of patients with osteosarcoma”
verfasst von:
Yuekui Jian, Xiaobin Tian, Bo Li, Zhuojia Zhou, Xinglin Wu
Erschienen in:
Tumor Biology
|
Ausgabe 5/2015
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Abstract
With great interest, we read the article “ERCC polymorphisms and prognosis of patients with osteosarcoma” (by Li JS et al.), which has reached important conclusions about the relationship between ERCC polymorphisms and osteosarcoma prognosis. Through quantitative analysis, the meta-analysis showed that ERCC2 Lys751Gln (OR
GG vs. AA = 0.40 (95%CI = 0.1–0.86),
P
heterogeneity = 0.502;
I
2 = 0 %) and ERCC5 His46His (OR
CC vs. TT = 0.37 (95%CI = 0.15–0.93),
P
heterogeneity = 0.569;
I
2 = 0 %) polymorphisms might influence the prognosis of patients with osteosarcoma [
1]. The meta-analysis results are encouraging. Nevertheless, some deficiencies still existed that we would like to raise.