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Erschienen in: Journal of Neurology 12/2018

26.04.2018 | Review

Link between overweight/obese in children and youngsters and occurrence of multiple sclerosis

verfasst von: Thamina Rasul, Jette Lautrup Frederiksen

Erschienen in: Journal of Neurology | Ausgabe 12/2018

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Abstract

Background/aims

The prevalence of overweight/obesity is a major problem in the world, and the number of MS cases is increasing. This literature study examines the relationship between overweight/obesity in children and adolescents and later occurrence of MS.

Method

This is a complete literature survey. The search database is primarily Pubmed using MeSH terms “multiple sclerosis”, “obesity”, and “overweight”, and text words not to restrict searches.

Results

All included studies show a link between being overweight/obese and the presence of MS among people below 20 years of age. The relation is especially true for young girls. The same relation in boys is not significant.

Conclusion

The literature survey convincingly revealed a link between young overweight/obese and occurrence of MS, in particular for girls. There is a need for more and larger studies to investigate the molecular mechanisms that link obesity and MS.
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Literatur
2.
Zurück zum Zitat Harpsøe MC, Basit S, Andersson M, Nielsen NM, Frisch M, Wohlfahrt J, Nohr EA, Linneberg A, Jess T (2014) Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort. Int J Epidemiol 43(3):843–855CrossRef Harpsøe MC, Basit S, Andersson M, Nielsen NM, Frisch M, Wohlfahrt J, Nohr EA, Linneberg A, Jess T (2014) Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort. Int J Epidemiol 43(3):843–855CrossRef
3.
Zurück zum Zitat Trapp BD, Nave KA (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31:247–269CrossRef Trapp BD, Nave KA (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31:247–269CrossRef
4.
Zurück zum Zitat Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, Thompson AJ (2014) Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology 83(11):1022–1024CrossRef Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, Thompson AJ (2014) Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology 83(11):1022–1024CrossRef
5.
Zurück zum Zitat Feldt-Rasmussen U, Baslund Bo, Sørensen PS, Soelberg P, Søren F, Kastrup J. Lærebog i medicin FADL’s forlag 1, Udgave Feldt-Rasmussen U, Baslund Bo, Sørensen PS, Soelberg P, Søren F, Kastrup J. Lærebog i medicin FADL’s forlag 1, Udgave
6.
Zurück zum Zitat Paulson Olaf B, Flemming G, Sørensen P. Klinisk neurologi og neurokirurgi FADL’s forlag 4, Udgave Paulson Olaf B, Flemming G, Sørensen P. Klinisk neurologi og neurokirurgi FADL’s forlag 4, Udgave
7.
Zurück zum Zitat Weissert R (2013) The immune pathogenesis of multiple sclerosis. J Neuroimmune Pharmacol 8(4):857–866CrossRef Weissert R (2013) The immune pathogenesis of multiple sclerosis. J Neuroimmune Pharmacol 8(4):857–866CrossRef
8.
Zurück zum Zitat Miller DH1, Chard DT, Ciccarelli O (2012) Clinically isolated syndromes. Lancet Neurol 11(2):157–169CrossRef Miller DH1, Chard DT, Ciccarelli O (2012) Clinically isolated syndromes. Lancet Neurol 11(2):157–169CrossRef
9.
Zurück zum Zitat Corey-Bloom J, David RB. Clinical adult neurology, 3rd edn Corey-Bloom J, David RB. Clinical adult neurology, 3rd edn
10.
Zurück zum Zitat Munger KL, Chitnis T, Ascherio A (2009) Body size and risk of MS in two cohorts of US women. Neurology 73(19):1543–1550CrossRef Munger KL, Chitnis T, Ascherio A (2009) Body size and risk of MS in two cohorts of US women. Neurology 73(19):1543–1550CrossRef
11.
Zurück zum Zitat Hedström AK, Olsson T, Alfredsson L (2012) High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 18(9):1334–1336CrossRef Hedström AK, Olsson T, Alfredsson L (2012) High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 18(9):1334–1336CrossRef
12.
Zurück zum Zitat Munger KL, Bentzen J, Laursen B, Stenager E, Koch-Henriksen N, Sørensen TI, Baker JL (2013) Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler 19(10):1323–1329CrossRef Munger KL, Bentzen J, Laursen B, Stenager E, Koch-Henriksen N, Sørensen TI, Baker JL (2013) Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler 19(10):1323–1329CrossRef
13.
Zurück zum Zitat Langer-Gould A, Brara SM, Beaber BE, Koebnick C (2013) Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology 80(6):548–552CrossRef Langer-Gould A, Brara SM, Beaber BE, Koebnick C (2013) Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology 80(6):548–552CrossRef
14.
Zurück zum Zitat Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L (2014) Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology 82(10):865–872CrossRef Hedström AK, Lima Bomfim I, Barcellos L, Gianfrancesco M, Schaefer C, Kockum I, Olsson T, Alfredsson L (2014) Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology 82(10):865–872CrossRef
15.
Zurück zum Zitat Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF (2014) Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract 8(5):e435–e447CrossRef Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, Bellesis KH, Bernstein A, Hedstrom AK, Kockum I, Alfredsson L, Olsson T, Schaefer C, Barcellos LF (2014) Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract 8(5):e435–e447CrossRef
16.
Zurück zum Zitat Wesnes K, Riise T, Casetta I, Drulovic J, Granieri E, Holmøy T, Kampman MT, Landtblom AM, Lauer K, Lossius A, Magalhaes S, Pekmezovic T, Bjørnevik K, Wolfson C, Pugliatti M, Myhr KM (2015) Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Mult Scler 21(4):388–395CrossRef Wesnes K, Riise T, Casetta I, Drulovic J, Granieri E, Holmøy T, Kampman MT, Landtblom AM, Lauer K, Lossius A, Magalhaes S, Pekmezovic T, Bjørnevik K, Wolfson C, Pugliatti M, Myhr KM (2015) Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Mult Scler 21(4):388–395CrossRef
17.
Zurück zum Zitat Kavak KS, Teter BE, Hagemeier J, Zakalik K, Weinstock-Guttman B, New York State Multiple Sclerosis Consortium (2015) Higher weight in adolescence and young adulthood is associated with an earlier age at multiple sclerosis onset. Mult Scler 21(7):858–865CrossRef Kavak KS, Teter BE, Hagemeier J, Zakalik K, Weinstock-Guttman B, New York State Multiple Sclerosis Consortium (2015) Higher weight in adolescence and young adulthood is associated with an earlier age at multiple sclerosis onset. Mult Scler 21(7):858–865CrossRef
18.
Zurück zum Zitat Hedström AK, Olsson T, Alfredsson L (2016) Body mass index during adolescence, rather than childhood, is critical in determining MS risk. Mult Scler 22(7):878–883CrossRef Hedström AK, Olsson T, Alfredsson L (2016) Body mass index during adolescence, rather than childhood, is critical in determining MS risk. Mult Scler 22(7):878–883CrossRef
19.
Zurück zum Zitat Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296(23):2832–2838CrossRef Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296(23):2832–2838CrossRef
20.
Zurück zum Zitat Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72(3):690–693CrossRef Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72(3):690–693CrossRef
21.
Zurück zum Zitat Mai XM, Chen Y, Camargo CA Jr et al (2012) Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. Am J Epidemiol 175:1029–1036CrossRef Mai XM, Chen Y, Camargo CA Jr et al (2012) Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. Am J Epidemiol 175:1029–1036CrossRef
22.
Zurück zum Zitat Bäärnhielm M, Hedström AK, Kockum I, Sundqvist E, Gustafsson SA, Hillert J, Olsson T, Alfredsson L (2012) Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1* 15. Eur J Neurol 19(7):955–962CrossRef Bäärnhielm M, Hedström AK, Kockum I, Sundqvist E, Gustafsson SA, Hillert J, Olsson T, Alfredsson L (2012) Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1* 15. Eur J Neurol 19(7):955–962CrossRef
23.
Zurück zum Zitat Aleksandrova K, Nimptsch K, Pischon T (2013) Influence of obesity and related metabolic alterations on colorectal cancer risk. Curr Nutr Rep 2:1–9CrossRef Aleksandrova K, Nimptsch K, Pischon T (2013) Influence of obesity and related metabolic alterations on colorectal cancer risk. Curr Nutr Rep 2:1–9CrossRef
24.
Zurück zum Zitat Nishimura S, Manabe I, Nagasaki M et al (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation on obesity. Nat Med 15:914–920 Nishimura S, Manabe I, Nagasaki M et al (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation on obesity. Nat Med 15:914–920
25.
Zurück zum Zitat Kasper LH, Shoemaker J (2010) Multiple sclerosis immunology: the healthy immune system vs. the MS immune system. Neurology 74(Suppl 1):S2–S8CrossRef Kasper LH, Shoemaker J (2010) Multiple sclerosis immunology: the healthy immune system vs. the MS immune system. Neurology 74(Suppl 1):S2–S8CrossRef
26.
Zurück zum Zitat Gøbel RJ, Jensen SM, Frøkiaer H et al (2012) Obesity, inflammation and metabolic syndrome in Danish adolescents. Acta Paedatr 101:192–200CrossRef Gøbel RJ, Jensen SM, Frøkiaer H et al (2012) Obesity, inflammation and metabolic syndrome in Danish adolescents. Acta Paedatr 101:192–200CrossRef
27.
Zurück zum Zitat Emamgholipour SI, Sm E, Hossein-nezhad A, Mirzaei K, Maghbooli Z, Sahraian MA (2013) Adipocytokine profile, cytokine levels and foxp3 expression in multiple sclerosis: a possible link to susceptibility and clinical course of disease. PLoS One 8(10):e76555CrossRef Emamgholipour SI, Sm E, Hossein-nezhad A, Mirzaei K, Maghbooli Z, Sahraian MA (2013) Adipocytokine profile, cytokine levels and foxp3 expression in multiple sclerosis: a possible link to susceptibility and clinical course of disease. PLoS One 8(10):e76555CrossRef
28.
Zurück zum Zitat De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G (2007) A key role of leptin in the control of regulatory T cell proliferation. Immunity 26(2):241–255CrossRef De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G (2007) A key role of leptin in the control of regulatory T cell proliferation. Immunity 26(2):241–255CrossRef
29.
Zurück zum Zitat Kraszula L, Jasińska A, Eusebio M, Kuna P, Głąbiński A, Pietruczuk M (2012) Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurol Neurochir Pol 46(1):22–28 Kraszula L, Jasińska A, Eusebio M, Kuna P, Głąbiński A, Pietruczuk M (2012) Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurol Neurochir Pol 46(1):22–28
30.
Zurück zum Zitat Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897–901CrossRef Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897–901CrossRef
31.
Zurück zum Zitat Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S (2005) Leptin increase in multiple sclerosis associates with reduced number of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci USA 102(14):5150–5155CrossRef Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S (2005) Leptin increase in multiple sclerosis associates with reduced number of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci USA 102(14):5150–5155CrossRef
32.
Zurück zum Zitat Evangelopoulos ME, Koutsis G, Markianos M (2014) Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis. Autoimmune Dis 2014:486282PubMedPubMedCentral Evangelopoulos ME, Koutsis G, Markianos M (2014) Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis. Autoimmune Dis 2014:486282PubMedPubMedCentral
33.
Zurück zum Zitat Messina S, Vargas-Lowy D, Musallam A, Healy BC, Kivisakk P, Gandhi R, Bove R, Gholipour T, Khoury S, Weiner HL, Chitnis T (2013) Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol 13:172CrossRef Messina S, Vargas-Lowy D, Musallam A, Healy BC, Kivisakk P, Gandhi R, Bove R, Gholipour T, Khoury S, Weiner HL, Chitnis T (2013) Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol 13:172CrossRef
34.
Zurück zum Zitat Matarese G, Procaccini C, De Rosa V (2008) The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J Leukoc Biol 84(4):893–899CrossRef Matarese G, Procaccini C, De Rosa V (2008) The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J Leukoc Biol 84(4):893–899CrossRef
35.
Zurück zum Zitat Hietaharju A, Kuusisto H, Nieminen R, Vuolteenaho K, Elovaara I, Moilanen E (2010) Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: a Finnish co-twin study. Eur J Neurol 17(2):332–334CrossRef Hietaharju A, Kuusisto H, Nieminen R, Vuolteenaho K, Elovaara I, Moilanen E (2010) Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: a Finnish co-twin study. Eur J Neurol 17(2):332–334CrossRef
36.
Zurück zum Zitat Natarajan R, Hagman S, Hämälainen M, Leppänen T, Dastidar P, Moilanen E, Elovaara I (2015) Adipsin is associated with multiple sclerosis: a follow-up study of adipokines. Mult Scler Int 2015:371734PubMedPubMedCentral Natarajan R, Hagman S, Hämälainen M, Leppänen T, Dastidar P, Moilanen E, Elovaara I (2015) Adipsin is associated with multiple sclerosis: a follow-up study of adipokines. Mult Scler Int 2015:371734PubMedPubMedCentral
Metadaten
Titel
Link between overweight/obese in children and youngsters and occurrence of multiple sclerosis
verfasst von
Thamina Rasul
Jette Lautrup Frederiksen
Publikationsdatum
26.04.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 12/2018
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-8869-9

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