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Diabetologia

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01.07.2003 | Article

Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies

verfasst von: Dr. A. Jellema, M. P. A. Zeegers, E. J. M. Feskens, P. C. Dagnelie, R. P. Mensink

Erschienen in: Diabetologia | Ausgabe 7/2003

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Abstract

Aims/hypothesis

Several case-control studies have examined the association between the Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and results could therefore be conflicting.

Methods

We systematically reviewed the literature by means of a meta-analysis and investigated sources of heterogeneity in results of different studies.

Results

The summary risk ratio, based on 3408 cases and 5419 control cases from 27 studies, was 1.25 (95% CI 1.05–1.48). The results, however, differed according to the type of study, method of verifying non-diabetic status of the control subjects, and age of the case subjects. Population-based studies reported lower odds ratios than hospital-based studies (OR 0.98, 95% CI 0.74–1.30 vs OR 1.43, 95% CI 1.17–1.74). Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03). Finally, the odds ratio reduced with increasing age (p=0.03).

Conclusion/interpretation

Overall, carriers of the 972Arg variant of the IRS-1 gene are at a 25% increased risk of having Type 2 diabetes compared with non-carriers. The odds ratios are generally higher in hospital-based studies, including relatively young, symptomatic, cases.

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Titel: Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies
verfasst von: Dr. A. Jellema
M. P. A. Zeegers
E. J. M. Feskens
P. C. Dagnelie
R. P. Mensink
Publikationsdatum: 01.07.2003
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 7/2003
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-003-1126-4

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Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies

Abstract

Aims/hypothesis

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Conclusion/interpretation

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