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Diabetologia

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01.10.2008 | Commentary

A genetic link between type 2 diabetes and prostate cancer

verfasst von: T. M. Frayling, H. Colhoun, J. C. Florez

Erschienen in: Diabetologia | Ausgabe 10/2008

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Abstract

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

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Titel: A genetic link between type 2 diabetes and prostate cancer
verfasst von: T. M. Frayling
H. Colhoun
J. C. Florez
Publikationsdatum: 01.10.2008
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 10/2008
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-008-1114-9

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