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Erschienen in:
01.02.2009 | Short Communication
Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors
Erschienen in: Diabetologia | Ausgabe 2/2009
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Aims/hypothesis
We previously reported that the plasma levels of the endocannabinoid, 2-arachidonoylglycerol (2-AG), in a cohort of viscerally obese men are directly correlated with visceral adipose tissue (VAT) accumulation and metabolic risk factors including low HDL-cholesterol and high triacylglycerol. It is not known, however, if such correlations persist after vigorous lifestyle interventions that reduce metabolic risk factors. We analysed the changes in endocannabinoid levels in a subsample from the same cohort following a 1 year lifestyle modification programme, and correlated them with changes in VAT and metabolic risk factors.
Methods
Forty-nine viscerally obese men (average age 49 years, BMI 30.9 kg/m2, waist 107.3 cm) underwent a 1 year lifestyle modification programme including healthy eating and physical activity. Plasma levels of 2-AG and the other most studied endocannabinoid, anandamide, were measured by liquid chromatography–mass spectrometry. Anthropometric and metabolic risk factors, including VAT, insulin resistance and glucose intolerance, HDL-cholesterol and triacylglycerol, were measured.
Results
Most risk factors were improved by the intervention, which led to a significant decrease in body weight (−6.4 kg, p < 0.0001), waist circumference (−8.0 cm, p < 0.0001) and VAT (−30%, p < 0.0001), and in plasma 2-AG (−62.3%, p < 0.0001) and anandamide (−7.1%, p = 0.005) levels. The decrease in levels of 2-AG but not those of anandamide correlated with decreases in VAT and triacylglycerol levels, and with the increase in HDL3-cholesterol levels. Multivariate analyses suggested that decreases in 2-AG and VAT were both independently associated with decreases in triacylglycerol.
Conclusions/interpretation
This study shows that a strong correlation exists between 2-AG levels and high plasma triacylglycerol and low HDL3-cholesterol in viscerally obese men.