Skip to main content
Erschienen in: Osteoporosis International 6/2005

01.06.2005 | Review

Assessment of fracture risk

verfasst von: John A. Kanis, Frederik Borgstrom, Chris De Laet, Helena Johansson, Olof Johnell, Bengt Jonsson, Anders Oden, Niklas Zethraeus, Bruce Pfleger, Nikolai Khaltaev

Erschienen in: Osteoporosis International | Ausgabe 6/2005

Einloggen, um Zugang zu erhalten

Abstract

The diagnosis of osteoporosis is based on the measurement of bone mineral density (BMD). There are a number of clinical risk factors that provide information on fracture risk over and above that given by BMD. The assessment of fracture risk thus needs to be distinguished from diagnosis to take account of the independent value of the clinical risk factors. These include age, a prior fragility fracture, a parental history of hip fracture, smoking, use of systemic corticosteroids, excess alcohol intake and rheumatoid arthritis. The independent contribution of these risk factors can be integrated by the calculation of fracture probability with or without the use of BMD. Treatment can then be offered to those identified to have a fracture probability greater than an intervention threshold.
Literatur
1.
Zurück zum Zitat Anonymous (1993) Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94:646–650CrossRefPubMed Anonymous (1993) Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 94:646–650CrossRefPubMed
2.
Zurück zum Zitat Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D, on behalf of the European Foundation for Osteoporosis and Bone Disease (1997) Guidelines for diagnosis and management of osteoporosis. Osteoporos Int 7:390–406PubMed Kanis JA, Delmas P, Burckhardt P, Cooper C, Torgerson D, on behalf of the European Foundation for Osteoporosis and Bone Disease (1997) Guidelines for diagnosis and management of osteoporosis. Osteoporos Int 7:390–406PubMed
3.
Zurück zum Zitat Royal College of Physicians (1999) Clinical guidelines for the prevention and treatment of osteoporosis. RCP, London Royal College of Physicians (1999) Clinical guidelines for the prevention and treatment of osteoporosis. RCP, London
4.
Zurück zum Zitat National Osteoporosis Foundation (1998) Analyses of the effectiveness and cost of screening and treatment strategies for osteoporosis: a basis for development of practice guidelines. Osteoporos Int 8 (suppl 4):1–88CrossRef National Osteoporosis Foundation (1998) Analyses of the effectiveness and cost of screening and treatment strategies for osteoporosis: a basis for development of practice guidelines. Osteoporos Int 8 (suppl 4):1–88CrossRef
5.
Zurück zum Zitat Kanis JA, Glüer CC for the Committee of Scientific Advisors, International Osteoporosis Foundation (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202CrossRefPubMed Kanis JA, Glüer CC for the Committee of Scientific Advisors, International Osteoporosis Foundation (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11:192–202CrossRefPubMed
6.
Zurück zum Zitat Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C et al. (2002) A new approach to the development of assessment guidelines for osteoporosis. Osteoporos Int 13:527–536CrossRefPubMed Kanis JA, Black D, Cooper C, Dargent P, Dawson-Hughes B, De Laet C et al. (2002) A new approach to the development of assessment guidelines for osteoporosis. Osteoporos Int 13:527–536CrossRefPubMed
7.
Zurück zum Zitat World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report Series 843. WHO, Geneva World Health Organisation (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Technical Report Series 843. WHO, Geneva
8.
Zurück zum Zitat Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:17–1141PubMed Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:17–1141PubMed
9.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A (2000) Risk of hip fracture according to the World Health Organization criteria for osteoporosis and osteopenia. Bone 27:585–590CrossRefPubMed Kanis JA, Johnell O, Oden A, Jonsson B, De Laet C, Dawson A (2000) Risk of hip fracture according to the World Health Organization criteria for osteoporosis and osteopenia. Bone 27:585–590CrossRefPubMed
10.
Zurück zum Zitat Committee for Proprietary Medicinal Products (CPMP) (1997) Note for guidance on involutional osteoporosis in women. European Agency for the Evaluation of Medicinal Products, London (CPMP/EWP/552/95) Committee for Proprietary Medicinal Products (CPMP) (1997) Note for guidance on involutional osteoporosis in women. European Agency for the Evaluation of Medicinal Products, London (CPMP/EWP/552/95)
11.
Zurück zum Zitat World Health Organisation (1998) Guidelines for preclinical evaluation and clinical trials in osteoporosis. WHO, Geneva World Health Organisation (1998) Guidelines for preclinical evaluation and clinical trials in osteoporosis. WHO, Geneva
12.
Zurück zum Zitat Liu, Z, Piao J, Pang L, Qing X et al. (2002) The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab 20:181–189CrossRefPubMed Liu, Z, Piao J, Pang L, Qing X et al. (2002) The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab 20:181–189CrossRefPubMed
13.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, De Laet C, Mellstrom D (2001) Diagnosis of osteoporosis and fracture threshold in men. Calcif Tissue Int 69:218–221PubMed Kanis JA, Johnell O, Oden A, De Laet C, Mellstrom D (2001) Diagnosis of osteoporosis and fracture threshold in men. Calcif Tissue Int 69:218–221PubMed
14.
Zurück zum Zitat DeLaet CEDH, Van Hout BA, Burger H, Hofman A, Weel AEAM, Pols HAP (1998) Hip fracture prediction in elderly men and women: validation in the Rotterdam Study. J Bone Miner Res 13:1587–1593PubMed DeLaet CEDH, Van Hout BA, Burger H, Hofman A, Weel AEAM, Pols HAP (1998) Hip fracture prediction in elderly men and women: validation in the Rotterdam Study. J Bone Miner Res 13:1587–1593PubMed
15.
Zurück zum Zitat Ross P, Huang C, Davis J, Imose K, Yates J, Vogel J, Wasnich R (1995) Predicting vertebral deformity using bone densitometry at various skeletal sites and calcaneous ultrasound. Bone 16:325–332CrossRefPubMed Ross P, Huang C, Davis J, Imose K, Yates J, Vogel J, Wasnich R (1995) Predicting vertebral deformity using bone densitometry at various skeletal sites and calcaneous ultrasound. Bone 16:325–332CrossRefPubMed
16.
Zurück zum Zitat Lunt M, Felsenberg D, Reeve J, Benevolenskaya L, Cannata J, Dequeker J (1997) Bone density variation and its effect on risk of vertebral deformity in men and women studied in thirteen European Centres: the EVOS Study. J Bone Miner Res 12:1883–1894PubMed Lunt M, Felsenberg D, Reeve J, Benevolenskaya L, Cannata J, Dequeker J (1997) Bone density variation and its effect on risk of vertebral deformity in men and women studied in thirteen European Centres: the EVOS Study. J Bone Miner Res 12:1883–1894PubMed
17.
Zurück zum Zitat Faulkner KG, von Stetten E, Miller P (1999) Discordance in patient classification using T-scores. J Clin Densitom 2:343–350CrossRefPubMed Faulkner KG, von Stetten E, Miller P (1999) Discordance in patient classification using T-scores. J Clin Densitom 2:343–350CrossRefPubMed
18.
Zurück zum Zitat Arlot ME, Sornay-Rendu E, Garnero P, Vey-Marty B, Delmas PD (1997) Apparent pre- and postmenopausal bone loss evaluated by DXA at different skeletal sites in women: the OFELY cohort. J Bone Miner Res 12:683–690 Arlot ME, Sornay-Rendu E, Garnero P, Vey-Marty B, Delmas PD (1997) Apparent pre- and postmenopausal bone loss evaluated by DXA at different skeletal sites in women: the OFELY cohort. J Bone Miner Res 12:683–690
19.
Zurück zum Zitat Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed Marshall D, Johnell O, Wedel H (1996) Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312:1254–1259PubMed
20.
Zurück zum Zitat Cooper C, Aihie A (1994) Osteoporosis: recent advances in pathogenesis and treatment. Q J Med 87:203–209PubMed Cooper C, Aihie A (1994) Osteoporosis: recent advances in pathogenesis and treatment. Q J Med 87:203–209PubMed
21.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, De Laet C, Jonsson B, Dawson A (2001) Ten year risk of osteoporotic fracture and the effect of risk factors on screening strategies. Bone 30:251–258CrossRef Kanis JA, Johnell O, Oden A, De Laet C, Jonsson B, Dawson A (2001) Ten year risk of osteoporotic fracture and the effect of risk factors on screening strategies. Bone 30:251–258CrossRef
22.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Jonsson B, Dawson A, Dere W (2000) Risk of hip fracture in Sweden according to relative risk: an analysis applied to the population of Sweden. Osteoporos Int 11:120–127PubMed Kanis JA, Johnell O, Oden A, Jonsson B, Dawson A, Dere W (2000) Risk of hip fracture in Sweden according to relative risk: an analysis applied to the population of Sweden. Osteoporos Int 11:120–127PubMed
23.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Jonsson B, DeLaet C, Dawson A (2000) Prediction of fracture from low bone mineral density measurements overestimates risk. Bone 26:387–391CrossRefPubMed Kanis JA, Johnell O, Oden A, Jonsson B, DeLaet C, Dawson A (2000) Prediction of fracture from low bone mineral density measurements overestimates risk. Bone 26:387–391CrossRefPubMed
24.
Zurück zum Zitat Oden A, Dawson A, Dere W, Johnell O, Jonsson B, Kanis JA (1999) Lifetime risk of hip fracture is underestimated. Osteoporos Int 8:599–603CrossRef Oden A, Dawson A, Dere W, Johnell O, Jonsson B, Kanis JA (1999) Lifetime risk of hip fracture is underestimated. Osteoporos Int 8:599–603CrossRef
25.
Zurück zum Zitat Hui SL, Slemenda CW, Johnston CC (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804–1809PubMed Hui SL, Slemenda CW, Johnston CC (1988) Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 81:1804–1809PubMed
26.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B (2001) Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 12:989–995CrossRefPubMed Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B (2001) Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 12:989–995CrossRefPubMed
27.
Zurück zum Zitat Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359:1929–1936CrossRefPubMed Kanis JA (2002) Diagnosis of osteoporosis and assessment of fracture risk. Lancet 359:1929–1936CrossRefPubMed
28.
Zurück zum Zitat Johnell O, Gullberg B, Kanis JA et al. (1995) Risk factors for hip fracture in European women: the MEDOS Study. J Bone Miner Res 10:1802–1815PubMed Johnell O, Gullberg B, Kanis JA et al. (1995) Risk factors for hip fracture in European women: the MEDOS Study. J Bone Miner Res 10:1802–1815PubMed
29.
Zurück zum Zitat Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. N Engl J Med 332:767–773CrossRefPubMed Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995) Risk factors for hip fracture in white women. N Engl J Med 332:767–773CrossRefPubMed
30.
Zurück zum Zitat Compston JE (1992) Risk factors for osteoporosis. Clin Endocrinol 36:223–224 Compston JE (1992) Risk factors for osteoporosis. Clin Endocrinol 36:223–224
31.
Zurück zum Zitat Ribot C, Pouilles JM, Bonneu M, Tremollieres F (1992) Assessment of the risk of postmenopausal osteoporosis using clinical risk factors. Clin Endocrinol 36:225–228 Ribot C, Pouilles JM, Bonneu M, Tremollieres F (1992) Assessment of the risk of postmenopausal osteoporosis using clinical risk factors. Clin Endocrinol 36:225–228
32.
Zurück zum Zitat Kanis JA, Johnell O, Gullberg B, Allander A, Elffors L, Dequeker J et al. (1999) Risk factors for hip fracture in European men. The MEDOS study. Osteoporos Int 9:45–54CrossRefPubMed Kanis JA, Johnell O, Gullberg B, Allander A, Elffors L, Dequeker J et al. (1999) Risk factors for hip fracture in European men. The MEDOS study. Osteoporos Int 9:45–54CrossRefPubMed
33.
Zurück zum Zitat Nguyen T, Sambrook SP, Kelly P, Jones G, Freund J, Eisman J (1993) Prediction of osteoporotic fractures by postural instability and bone density. BMJ 307:1111–1115PubMed Nguyen T, Sambrook SP, Kelly P, Jones G, Freund J, Eisman J (1993) Prediction of osteoporotic fractures by postural instability and bone density. BMJ 307:1111–1115PubMed
34.
Zurück zum Zitat Poor G, Atkinson EJ, O’Fallon WM, Melton LJ III (1995) Predictors of hip fractures in elderly men. J Bone Miner Res 10:1900–1907PubMed Poor G, Atkinson EJ, O’Fallon WM, Melton LJ III (1995) Predictors of hip fractures in elderly men. J Bone Miner Res 10:1900–1907PubMed
35.
Zurück zum Zitat Kanis JA, McCloskey EV (1996) Evaluation of the risk of hip fracture. Bone 18:127–132CrossRef Kanis JA, McCloskey EV (1996) Evaluation of the risk of hip fracture. Bone 18:127–132CrossRef
36.
Zurück zum Zitat Kanis JA, De Laet C, Delmas P, Garnero P, Johansson H, Johnell O, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Oden A, Pols H, Reeve J, Silman A, Tenenhouse A (2004) A meta-analysis of previous fracture and fracture risk. Bone 35:375–382CrossRef Kanis JA, De Laet C, Delmas P, Garnero P, Johansson H, Johnell O, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Oden A, Pols H, Reeve J, Silman A, Tenenhouse A (2004) A meta-analysis of previous fracture and fracture risk. Bone 35:375–382CrossRef
37.
Zurück zum Zitat Kanis JA, Johansson H, Oden A, Johnell O, De Laet C, Melton LJ, Tenenhouse A, Reeve J, Silman AJ, Pols HAP, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19:893–899PubMed Kanis JA, Johansson H, Oden A, Johnell O, De Laet C, Melton LJ, Tenenhouse A, Reeve J, Silman AJ, Pols HAP, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19:893–899PubMed
38.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA, Fujiwara S, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman AJ, Tenenhouse A (2004) Smoking and fracture risk: a meta-analysis. Osteoporos Int (in press) Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA, Fujiwara S, Kroger H, McCloskey EV, Mellstrom D, Melton LJ, Pols H, Reeve J, Silman AJ, Tenenhouse A (2004) Smoking and fracture risk: a meta-analysis. Osteoporos Int (in press)
39.
Zurück zum Zitat Kanis JA, Johansson H, Oden A, Johnell O, De Laet C, Eisman JA, McCloskey EV, Mellstrom D, Melton LJ, Pols HAP, Reeve J, Silman AJ, Tenenhouse A (2004) A family history of fracture and fracture risk: a meta-analysis. Bone (in press) Kanis JA, Johansson H, Oden A, Johnell O, De Laet C, Eisman JA, McCloskey EV, Mellstrom D, Melton LJ, Pols HAP, Reeve J, Silman AJ, Tenenhouse A (2004) A family history of fracture and fracture risk: a meta-analysis. Bone (in press)
40.
Zurück zum Zitat De Laet C, Kanis JA, Oden A, Johansson H, Johnell O, Delmas P et al. (2004) Body mass index as a predictor of fracture risk: A meta-analysis. Osteoporos Int (in press) De Laet C, Kanis JA, Oden A, Johansson H, Johnell O, Delmas P et al. (2004) Body mass index as a predictor of fracture risk: A meta-analysis. Osteoporos Int (in press)
41.
Zurück zum Zitat Kanis JA, Johansson H, Johnell O, Oden A, De Laet C, Eisman JA, Pols H, Tenenhouse A (2004) Alcohol intake as a risk factor for fracture. Osteoporos Int (in press) Kanis JA, Johansson H, Johnell O, Oden A, De Laet C, Eisman JA, Pols H, Tenenhouse A (2004) Alcohol intake as a risk factor for fracture. Osteoporos Int (in press)
42.
Zurück zum Zitat Van Staa TP, Leufkens HGM, Abenhaim L, Zhang B, Cooper C (2001) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:993–1000 Van Staa TP, Leufkens HGM, Abenhaim L, Zhang B, Cooper C (2001) Use of oral corticosteroids and risk of fractures. J Bone Miner Res 15:993–1000
43.
Zurück zum Zitat Van Staa TP, Leufkens HGM, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int 13:777–787PubMed Van Staa TP, Leufkens HGM, Cooper C (2002) The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int 13:777–787PubMed
44.
Zurück zum Zitat Klotzbuecher CM, Ross PD, Landsman PB, Abbot TA, Berger M (2000) Patients with prior fractures have increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–727PubMed Klotzbuecher CM, Ross PD, Landsman PB, Abbot TA, Berger M (2000) Patients with prior fractures have increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–727PubMed
45.
Zurück zum Zitat Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non black, osteoporotic women. Osteoporos Int 3:120–126PubMed Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non black, osteoporotic women. Osteoporos Int 3:120–126PubMed
46.
Zurück zum Zitat Delmas PD (ed) (2000) The use of biochemical markers of bone turnover in the management of post-menopausal osteoporosis. Osteoporosis Int 11:S1–S76CrossRef Delmas PD (ed) (2000) The use of biochemical markers of bone turnover in the management of post-menopausal osteoporosis. Osteoporosis Int 11:S1–S76CrossRef
47.
Zurück zum Zitat Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women. The Ofely study. J Bone Miner Res 15:1526–1536PubMed Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women. The Ofely study. J Bone Miner Res 15:1526–1536PubMed
48.
Zurück zum Zitat Garnero P, Hauser E, Chapuy MC, Marcelli C, Grandjean H, Muller C, Cormier C, Breard G, Meunier PJ, Delmas PD (1996) Markers of bone turnover predict hip fractures in elderly women. The EPIDOS prospective study. J Bone Miner Res 11:1531–1538PubMed Garnero P, Hauser E, Chapuy MC, Marcelli C, Grandjean H, Muller C, Cormier C, Breard G, Meunier PJ, Delmas PD (1996) Markers of bone turnover predict hip fractures in elderly women. The EPIDOS prospective study. J Bone Miner Res 11:1531–1538PubMed
49.
Zurück zum Zitat Hansen M, Overgaard K, Riis B, Christiansen C (1991) Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ 303:961–964PubMed Hansen M, Overgaard K, Riis B, Christiansen C (1991) Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ 303:961–964PubMed
50.
Zurück zum Zitat Johnell O, Oden A, DeLaet C, Garnero P, Delmas PD, Kanis JA (2002) Biochemical indices of bone turnover and the assessment of fracture probability. Osteoporos Int 13:523–526CrossRefPubMed Johnell O, Oden A, DeLaet C, Garnero P, Delmas PD, Kanis JA (2002) Biochemical indices of bone turnover and the assessment of fracture probability. Osteoporos Int 13:523–526CrossRefPubMed
51.
Zurück zum Zitat Dyslipidaemia Advisory Group on behalf of the Scientific Committee of the National Heart Foundation of New Zealand (1996) National Heart Foundation Clinical Guidelines for the assessment and management of dyslipidaemia. N Z Med J 109:224–232PubMed Dyslipidaemia Advisory Group on behalf of the Scientific Committee of the National Heart Foundation of New Zealand (1996) National Heart Foundation Clinical Guidelines for the assessment and management of dyslipidaemia. N Z Med J 109:224–232PubMed
52.
Zurück zum Zitat Kanis JA, Dawson A, Oden A, Johnell O, De Laet C, Jonsson B (2001) Cost-effectiveness of preventing hip fracture in the general female population. Osteoporos Int 12:356–361CrossRefPubMed Kanis JA, Dawson A, Oden A, Johnell O, De Laet C, Jonsson B (2001) Cost-effectiveness of preventing hip fracture in the general female population. Osteoporos Int 12:356–361CrossRefPubMed
53.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, Borgstrom F, Zethraeus N, De Laet C, Jonsson B (2004) The risk and burden of vertebral fractures in Sweden. Osteoporos Int 15:20–26CrossRefPubMed Kanis JA, Johnell O, Oden A, Borgstrom F, Zethraeus N, De Laet C, Jonsson B (2004) The risk and burden of vertebral fractures in Sweden. Osteoporos Int 15:20–26CrossRefPubMed
54.
Zurück zum Zitat Kanis JA, Oden A, Johnell O, Jonsson B, De Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427CrossRefPubMed Kanis JA, Oden A, Johnell O, Jonsson B, De Laet C, Dawson A (2001) The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int 12:417–427CrossRefPubMed
55.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, De Laet C, Oglesby A, Jonsson B (2002) Intervention thresholds for osteoporosis. Bone 13:26–31 Kanis JA, Johnell O, Oden A, De Laet C, Oglesby A, Jonsson B (2002) Intervention thresholds for osteoporosis. Bone 13:26–31
56.
Zurück zum Zitat Kanis JA, Barton IP, Johnell O (2004) Risedronate decreases fracture risk in patients selected solely on the basis of prior vertebral fracture. Osteoporos Int (in press) Kanis JA, Barton IP, Johnell O (2004) Risedronate decreases fracture risk in patients selected solely on the basis of prior vertebral fracture. Osteoporos Int (in press)
57.
Zurück zum Zitat Johansson H, Oden A, Johnell O, Jonsson B, De Laet C, Oglesby A, McCloskey EV, Kayan K, Jalava T, Kanis JA (2004) Optimisation of BMD measurements to identify high risk groups for treatment—a test analysis. J Bone Miner Res 19:906–913PubMed Johansson H, Oden A, Johnell O, Jonsson B, De Laet C, Oglesby A, McCloskey EV, Kayan K, Jalava T, Kanis JA (2004) Optimisation of BMD measurements to identify high risk groups for treatment—a test analysis. J Bone Miner Res 19:906–913PubMed
Metadaten
Titel
Assessment of fracture risk
verfasst von
John A. Kanis
Frederik Borgstrom
Chris De Laet
Helena Johansson
Olof Johnell
Bengt Jonsson
Anders Oden
Niklas Zethraeus
Bruce Pfleger
Nikolai Khaltaev
Publikationsdatum
01.06.2005
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 6/2005
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-004-1780-5

Weitere Artikel der Ausgabe 6/2005

Osteoporosis International 6/2005 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.