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Osteoporosis International

Erschienen in:

01.12.2005 | Original Article

Relationship between bone mineral density and myocardial infarction in US adults

verfasst von: Jeanette H. Magnus, Danielle L. Broussard

Erschienen in: Osteoporosis International | Ausgabe 12/2005

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Abstract

Cardiovascular disease and osteoporosis have several common risk factors, and quite a few studies suggest a relationship between them. The objective of the present study was to explore the relationship between cardiovascular disease risk factors and bone mineral density in association with having had a previous myocardial infarction in a general population. This cross-sectional study was conducted using data for 5,050 women and men aged 50–79 years who participated in the Third National Health and Nutrition Examination Survey (NHANES III). Race/ethnic and gender-specific mean BMD values for young adults were used to determine race/ethnic and gender-specific T -scores to define osteoporosis and low BMD. Multiple logistic regression analysis revealed that subjects self-reporting a previous myocardial infarction had significantly higher odds (odds ratio 1.28, [95% confidence interval (CI), 1.01 to 1.63] p =0.04) of having low bone mineral density, when adjusting for cardiovascular disease and osteoporosis risk factors. Self-reported myocardial infarction was not significantly associated with low bone mineral density in women, (odds ratio 1.22, [95% CI, 0.80 to 1.86] p =0.37), but was significant in men, (odds ratio 1.39, [95% CI, 1.03 to 1.87] p =0.03). These findings demonstrate that male survivors of myocardial infarction have low bone mineral density. The pathophysiologic connection between the atherosclerotic and the osteoporotic processes needs further elucidation. It is also of importance to study the processes in both men and women.

Johansson C, Black D, Johnell O, Oden A, Mellstrom D (1998) Bone mineral density is a predictor of survival. Calcif Tissue Int 63:190–196CrossRefPubMed

von der Recke P, Hansen MA, Hassager C (1999) The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 106:273–278CrossRefPubMed

Mussolino ME, Madans JH, Gillum RF (2003) Bone mineral density and mortality in women and men: the NHANES I Epidemiologic Follow-up Study. Ann Epidemiol 13:692–697CrossRefPubMed

Trivedi DP, Khaw KT (2001) Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int 12:259–265CrossRefPubMed

Van Der Klift M, Pols HA, Geleijnse JM, Van Der Kuip DA, Hofman A, De Laet CE (2002) Bone mineral density and mortality in elderly men and women: the Rotterdam Study. Bone 30:643–648CrossRefPubMed

Mosca L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E (1997) Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Writing Group. Circulation 96:2468–2482PubMed

McFarlane SI, Muniyappa R, Shin JJ, Bahtiyar G, Sowers JR (2004) Osteoporosis and cardiovascular disease: brittle bones and boned arteries. Is there a link? Endocrine 23:1–10CrossRefPubMed

Alagiakrishnan K, Juby A, Hanley D, Tymchak W, Sclater A (2003) Role of vascular factors in osteoporosis. J Gerontol A Biol Sci Med Sci 58:362–366PubMed

Tanko LB, Bagger YZ, Christiansen C (2003) Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women. Calcif Tissue Int 73:15–20CrossRefPubMed

10.

Jorgensen L, Engstad T, Jacobsen BK (2001) Bone mineral density in acute stroke patients: low bone mineral density may predict first stroke in women. Stroke 32:47–51PubMed

11.

National Center for Health Statistics (1994) Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–1994. Vital Health Stat 1(32). DHHS publication No. (PHS) 94-1308. NCHS, Hyattsville, MD, USA

12.

Chen Z, Kooperberg C, Pettinger MB, Bassford T, Cauley JA, LaCroix AZ et al (2004) Validity of self-report for fractures among a multiethnic cohort of postmenopausal women: results from the Women’s Health Initiative observational study and clinical trials. Menopause 11:264–274CrossRefPubMed

13.

Bergmann MM, Byers T, Freedman DS, Mokdad A (1998) Validity of self-reported diagnoses leading to hospitalization: a comparison of self-reports with hospital records in a prospective study of American adults. Am J Epidemiol 147:969–977PubMed

14.

O’Mahony PG, Dobson R, Rodgers H, James OF, Thomson RG (1995) Validation of a population screening questionnaire to assess prevalence of stroke. Stroke 26:1334–1337PubMed

15.

Caraballo RS, Giovino GA, Pechacek TF, Mowery PD (2001) Factors associated with discrepancies between self-reports on cigarette smoking and measured serum cotinine levels among persons aged 17 years or older: Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol 153:807–814CrossRefPubMed

16.

National Center for Health Statistics (1996) NHANES III reference manuals and reports (CD-ROM). Centers for Disease Control and Prevention, Hyattsville, MD, USA

17.

Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8:468–489CrossRefPubMed

18.

Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141PubMed

19.

de Laet CE, van der Klift M, Hofman A, Pols HA (2002) Osteoporosis in men and women: A story about bone mineral density thresholds and hip fracture risk. J Bone Miner Res 17:2231–2236PubMed

20.

Broussard DL, Magnus JH (2004) Risk assessment and screening for low bone mineral density in a multi-ethnic population of women and men: Does one approach fit all? Osteoporos Int 15:349–360CrossRefPubMed

21.

Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J et al (2004) Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int 74:136–142CrossRefPubMed

22.

Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA (1999) High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet 354:971–975CrossRefPubMed

23.

Jankowska EA, Susanne C, Rogucka E, Medras M (2002) The inverse relationship between bone status and blood pressure among Polish men. Ann Hum Biol 29:63–73CrossRefPubMed

24.

Browner WS, Seeley DG, Vogt TM, Cummings SR (1991) Non-trauma mortality in elderly women with low bone mineral density. Study of Osteoporotic Fractures Research Group. Lancet 338:355–358CrossRefPubMed

25.

Browner WS, Pressman AR, Nevitt MC, Cauley JA, Cummings SR (1993) Association between low bone density and stroke in elderly women. The study of osteoporotic fractures. Stroke 24:940–946PubMed

26.

Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 15:1974–1980PubMed

27.

National Osteoporosis Foundation (1999) Physician’s guide to prevention and treatment of osteoporosis. Excerpta Medica, New Jersey, USA

28.

Nelson HD, Helfand M, Woolf SH, Allan JD (2002) Screening for postmenopausal osteoporosis: a review of the evidence for the US Preventive Services Task Force. Ann Intern Med 137:529–541PubMed

29.

Guerci AD, Spadaro LA, Goodman KJ, Lledo-Perez A, Newstein D, Lerner G et al (1998) Comparison of electron beam computed tomography scanning and conventional risk factor assessment for the prediction of angiographic coronary artery disease. J Am Coll Cardiol 32:673–679CrossRefPubMed

30.

Demer LL (2002) Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int J Epidemiol 31:737–741CrossRefPubMed

31.

Bostrom K (2001) Insights into the mechanism of vascular calcification. Am J Cardiol 88:20E–22ECrossRefPubMed

32.

Parhami F, Garfinkel A, Demer LL (2000) Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol 20:2346–2348PubMed

33.

Wilson PW, Kauppila LI, O’Donnell CJ, Kiel DP, Hannan M, Polak JM et al (2001) Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 103:1529–1534PubMed

34.

Iribarren C, Sidney S, Sternfeld B, Browner WS (2000) Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA 283:2810–2815CrossRefPubMed

35.

Keelan PC, Bielak LF, Ashai K, Jamjoum LS, Denktas AE, Rumberger JA et al (2001) Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiography. Circulation 104:412–417PubMed

36.

Banks LM, Lees B, MacSweeney JE, Stevenson JC (1994) Effect of degenerative spinal and aortic calcification on bone density measurements in post-menopausal women: links between osteoporosis and cardiovascular disease? Eur J Clin Invest 24:813–817PubMed

37.

Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, Chomka EV (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 62:209–213CrossRefPubMed

38.

Hak AE, Pols HA, van Hemert AM, Hofman A, Witteman JC (2000) Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 20:1926–1931PubMed

39.

Jie KG, Bots ML, Vermeer C, Witteman JC, Grobbee DE (1996) Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59:352–356CrossRefPubMed

40.

Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O’Donnell CJ, Wilson PW (2001) Bone loss and the progression of abdominal aortic calcification over a 25-year period: the Framingham Heart Study. Calcif Tissue Int 68:271–276PubMed

41.

Sugihara N, Matsuzaki M (1993) The influence of severe bone loss on mitral annular calcification in postmenopausal osteoporosis of elderly Japanese women. Jpn Circ J 57:14–26PubMed

42.

Aoyagi K, Ross PD, Orloff J, Davis JW, Katagiri H, Wasnich RD (2001) Low bone density is not associated with aortic calcification. Calcif Tissue Int 69:20–24CrossRefPubMed

43.

Drinka PJ, Bauwens SF, DeSmet AA (1992) Lack of correlation between aortic calcification and bone density. Wis Med J 91:299–301PubMed

44.

Frye MA, Melton LJ 3rd, Bryant SC, Fitzpatrick LA, Wahner HW, Schwartz RS et al (1992) Osteoporosis and calcification of the aorta. Bone Miner 19:185–194CrossRefPubMed

45.

Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V (2004) Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89:4246–4253CrossRefPubMed

46.

Uyama O, Yoshimoto Y, Yamamoto Y, Kawai A (1997) Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 28:1730–1732PubMed

47.

van der Klift M, Pols HA, Hak AE, Witteman JC, Hofman A, de Laet CE (2002) Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study. Calcif Tissue Int 70:443–449CrossRefPubMed

48.

Pennisi P, Signorelli SS, Riccobene S, Celotta G, Di Pino L, La Malfa T et al (2004) Low bone density and abnormal bone turnover in patients with atherosclerosis of peripheral vessels. Osteoporos Int 15:389–395CrossRefPubMed

49.

Qureshi AI, Suri MF, Kirmani JF, Divani AA (2004) The relative impact of inadequate primary and secondary prevention on cardiovascular mortality in the United States. Stroke 35:2346–2350CrossRefPubMed

Titel: Relationship between bone mineral density and myocardial infarction in US adults
verfasst von: Jeanette H. Magnus
Danielle L. Broussard
Publikationsdatum: 01.12.2005
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 12/2005
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-005-1999-9

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