Erschienen in:
01.08.2009 | Review
Depression and low bone mineral density: a meta-analysis of epidemiologic studies
verfasst von:
Q. Wu, J. H. Magnus, J. Liu, A. F. Bencaz, J. G. Hentz
Erschienen in:
Osteoporosis International
|
Ausgabe 8/2009
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Abstract
Summary
The association between depression and loss of bone mineral density (BMD) has been reported inconsistently. This meta-analysis, which pooled results from 14 qualifying individual studies, found that depression was associated with a significantly decreased BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression.
Introduction
The reported association between depression and loss of BMD has been controversial. This meta-analysis was conducted to determine whether depression and BMD are associated and to identify the variation in some subgroups.
Methods
English-language articles published before October 2008 were used as the data source. A total of six case-controlled and eight cross-sectional studies met prestated inclusion criteria (N = 10,523). Information on study design, participant characteristics, measurements of BMD and depression, and control for potential confounders was abstracted independently by two investigators using a standardized protocol.
Results
Overall, depression was associated with a significant decrease in mean BMD of spine (−0.053 g/cm2 [95% confidence interval {CI} −0.087 to −0.018 g/cm2]) and hip (−0.052 g/cm2 [95% CI −0.083 to −0.022 g/cm2]). A substantially greater BMD decrease was observed in depressed women (−0.076 g/cm2 in spine; −0.059 g/cm2 in hip) and in cases of clinical depression (−0.074 g/cm2 in spine; −0.080 g/cm2 in hip).
Conclusion
Depression is associated with low BMD, with a substantially greater BMD decrease in depressed women and in cases of clinical depression. Depression should be considered as an important risk factor for osteoporosis.