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Osteoporosis International
Erschienen in: Osteoporosis International 8/2012

01.08.2012 | Review

The effects of smoking on bone metabolism

verfasst von: V. Yoon, N. M. Maalouf, K. Sakhaee

Erschienen in: Osteoporosis International | Ausgabe 8/2012

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Abstract

Osteoporosis is a common, morbid and costly disorder characterized by deterioration in bone strength. Cigarette smoking is associated with reduced bone mineral density (BMD) and increased fracture risk. There are basic, clinical, and observational studies that define several of the underlying pathophysiologic mechanisms that predispose smokers to bone loss. Such mechanisms include alterations in calciotropic hormone metabolism and intestinal calcium absorption, dysregulation in sex hormone production and metabolism, alterations in adrenal cortical hormone metabolism and in the receptor activator of nuclear factor kappa-B (RANK), receptor activator of nuclear factor kappa-B ligand (RANKL), and osteoprotegerin (OPG) system (RANK–RANKL–OPG system), and direct cellular effects of cigarette use on bone cells. In addition, there is evidence of reversibility in the aforementioned mechanisms with smoking cessation. In summary, cigarette smoking is a reversible risk factor for osteoporosis and osteoporotic fractures through diverse pathophysiologic mechanisms.
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Metadaten
Titel
The effects of smoking on bone metabolism
verfasst von
V. Yoon
N. M. Maalouf
K. Sakhaee
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 8/2012
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-012-1940-y

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