Skip to main content
Erschienen in: Osteoporosis International 11/2013

01.11.2013 | Original Article

Secondary prevention of osteoporotic fractures—an “OPTIMAL” model of care from Singapore

verfasst von: M. Chandran, M. Z. W. Tan, M. Cheen, S. B. Tan, M. Leong, T. C. Lau

Erschienen in: Osteoporosis International | Ausgabe 11/2013

Einloggen, um Zugang zu erhalten

Abstract

Summary

A significant care gap exists in the management of osteoporotic fractures. Osteoporosis Patient Targeted and Integrated Management for Active Living (OPTIMAL) is a secondary fracture prevention program instituted in the public hospitals of Singapore. We aim to describe the operational characteristics of OPTIMAL and initial audit data of patients who were recruited into the program at Singapore General Hospital.

Introduction

Fractures often represent the first opportunity for care of osteoporosis. However, a significant care gap still exists in the management of these sentinel events and underdiagnosis and undertreatment of osteoporotic fractures are prevalent worldwide. Fracture liaison services run by care coordinators have been shown to reduce the fracture care gap. OPTIMAL is a clinician champion-driven, case manager-run secondary fracture prevention program set up in the public hospitals of Singapore in 2008.

Methods

We present the operational characteristics and initial audit data of OPTIMAL from the largest tertiary teaching hospital in Singapore.

Results

One thousand and fourteen patients have been recruited into OPTIMAL at our hospital since 2008, and 476 patients are currently in active follow-up. Two hundred and eighty-seven patients had completed a 2-year follow-up at the hospital as of August 2012 and were evaluated; 97.5 % of these patients had DXA evaluation upon enrollment into the program, and 62 % of the patients reported compliance with an exercise program over the 2-year follow-up. Compliance to osteoporosis medications as estimated by the medication possession ratio (MPR) was 72.8 ± 34.5 % at 2 years with patients maintaining good compliance (MPR ≥ 80 %) for an average of 20.2 months (95 % CI 19.3–21.1).

Conclusion

Our report provides the first compelling evidence of the potential success of a secondary fracture prevention program from an Asian country. The ultimate success of the program will be determined by fracture outcomes and cost effectiveness, but in the interim, clear evidence of enhanced assessment and treatment rates has been demonstrated.
Literatur
1.
Zurück zum Zitat Lau EM, Lee JK, Suriwongpaisal P, Saw SM, De SD, Khir A et al (2001) The incidence of hip fracture in four Asian countries the Asian Osteoporosis Study (AOS). Osteoporos Int 12(3):239–243PubMedCrossRef Lau EM, Lee JK, Suriwongpaisal P, Saw SM, De SD, Khir A et al (2001) The incidence of hip fracture in four Asian countries the Asian Osteoporosis Study (AOS). Osteoporos Int 12(3):239–243PubMedCrossRef
2.
Zurück zum Zitat Black DM, Thompson DE, Bauer DC, Ensrud K, Musliner T, Hochberg MC et al (2000) Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. J Clin Endocrinol Metab 85(11):4118–4124PubMedCrossRef Black DM, Thompson DE, Bauer DC, Ensrud K, Musliner T, Hochberg MC et al (2000) Fracture risk reduction with alendronate in women with osteoporosis: the Fracture Intervention Trial. FIT Research Group. J Clin Endocrinol Metab 85(11):4118–4124PubMedCrossRef
3.
Zurück zum Zitat Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809–1822PubMedCrossRef Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809–1822PubMedCrossRef
4.
Zurück zum Zitat Roy A, Heckman MG, O'Connor MI (2011) Optimizing screening for osteoporosis in patients with fragility hip fracture. Clin Orthop Relat Res 469(7):1925–1930PubMedCrossRef Roy A, Heckman MG, O'Connor MI (2011) Optimizing screening for osteoporosis in patients with fragility hip fracture. Clin Orthop Relat Res 469(7):1925–1930PubMedCrossRef
5.
Zurück zum Zitat Greenspan SL, Wyman A, Hooven FH, Adami S, Gehlbach S, Anderson FA et al (2012) Predictors of treatment with osteoporosis medications after recent fragility fractures in a multinational cohort of postmenopausal women. J Am Geriatr Soc 60(3):455–461PubMedCrossRef Greenspan SL, Wyman A, Hooven FH, Adami S, Gehlbach S, Anderson FA et al (2012) Predictors of treatment with osteoporosis medications after recent fragility fractures in a multinational cohort of postmenopausal women. J Am Geriatr Soc 60(3):455–461PubMedCrossRef
6.
Zurück zum Zitat Castel H, Bonneh DY, Sherf M, Liel Y (2001) Awareness of osteoporosis and compliance with management guidelines in patients with newly diagnosed low-impact fractures. Osteoporos Int 12(7):559–564PubMedCrossRef Castel H, Bonneh DY, Sherf M, Liel Y (2001) Awareness of osteoporosis and compliance with management guidelines in patients with newly diagnosed low-impact fractures. Osteoporos Int 12(7):559–564PubMedCrossRef
7.
Zurück zum Zitat Panneman MJM, Lips P, Sen SS, Herings RMC (2004) Undertreatment with anti-osteoporotic drugs after hospitalization for fracture. Osteoporos Int 15(2):120–124PubMedCrossRef Panneman MJM, Lips P, Sen SS, Herings RMC (2004) Undertreatment with anti-osteoporotic drugs after hospitalization for fracture. Osteoporos Int 15(2):120–124PubMedCrossRef
8.
Zurück zum Zitat Sugi MT, Sheridan K, Lewis L, Huang MH, Nattiv A, Kado DM et al (2012) Active referral intervention following fragility fractures leads to enhanced osteoporosis follow-up care. J Osteoporos 2012:234381PubMed Sugi MT, Sheridan K, Lewis L, Huang MH, Nattiv A, Kado DM et al (2012) Active referral intervention following fragility fractures leads to enhanced osteoporosis follow-up care. J Osteoporos 2012:234381PubMed
9.
Zurück zum Zitat Lih A, Nandapalan H, Kim M, Yap C, Lee P, Ganda K et al (2011) Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study. Osteoporos Int 22(3):849–858PubMedCrossRef Lih A, Nandapalan H, Kim M, Yap C, Lee P, Ganda K et al (2011) Targeted intervention reduces refracture rates in patients with incident non-vertebral osteoporotic fractures: a 4-year prospective controlled study. Osteoporos Int 22(3):849–858PubMedCrossRef
10.
Zurück zum Zitat Cooper MS, Palmer AJ, Seibel MJ (2012) Cost-effectiveness of the Concord Minimal Trauma Fracture Liaison service, a prospective, controlled fracture prevention study. Osteoporos Int 23(1):97–107PubMedCrossRef Cooper MS, Palmer AJ, Seibel MJ (2012) Cost-effectiveness of the Concord Minimal Trauma Fracture Liaison service, a prospective, controlled fracture prevention study. Osteoporos Int 23(1):97–107PubMedCrossRef
12.
Zurück zum Zitat Eisman JA, Bogoch ER, Dell R, Harrington JT, McKinney RE, McLellan A et al (2012) Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention. J Bone Miner Res 27(10):2039–2046PubMedCrossRef Eisman JA, Bogoch ER, Dell R, Harrington JT, McKinney RE, McLellan A et al (2012) Making the first fracture the last fracture: ASBMR task force report on secondary fracture prevention. J Bone Miner Res 27(10):2039–2046PubMedCrossRef
13.
Zurück zum Zitat Bogoch ER, Elliot-Gibson V, Beaton DE, Jamal SA, Josse RG, Murray TM et al (2006) Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopaedic environment. J Bone Joint Surg Am 88(1):25–34PubMedCrossRef Bogoch ER, Elliot-Gibson V, Beaton DE, Jamal SA, Josse RG, Murray TM et al (2006) Effective initiation of osteoporosis diagnosis and treatment for patients with a fragility fracture in an orthopaedic environment. J Bone Joint Surg Am 88(1):25–34PubMedCrossRef
14.
Zurück zum Zitat Sander B, Elliot-Gibson V, Beaton DE, Bogoch ER, Maetzel A (2008) A coordinator program in post-fracture osteoporosis management improves outcomes and saves costs. J Bone Joint Surg Am 90(6):1197–1205PubMedCrossRef Sander B, Elliot-Gibson V, Beaton DE, Bogoch ER, Maetzel A (2008) A coordinator program in post-fracture osteoporosis management improves outcomes and saves costs. J Bone Joint Surg Am 90(6):1197–1205PubMedCrossRef
15.
Zurück zum Zitat McLellan AR, Wolowacz SE, Zimovetz EA, Beard SM, Lock S, McCrink L et al (2011) Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 22(7):2083–2098PubMedCrossRef McLellan AR, Wolowacz SE, Zimovetz EA, Beard SM, Lock S, McCrink L et al (2011) Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 22(7):2083–2098PubMedCrossRef
16.
Zurück zum Zitat McLellan AR, Gallacher SJ, Fraser M, McQuillian C (2003) The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int 14(12):1028–1034PubMedCrossRef McLellan AR, Gallacher SJ, Fraser M, McQuillian C (2003) The fracture liaison service: success of a program for the evaluation and management of patients with osteoporotic fracture. Osteoporos Int 14(12):1028–1034PubMedCrossRef
17.
Zurück zum Zitat Dell R, Greene D, Schelkun SR, Williams K (2008) Osteoporosis disease management: the role of the orthopaedic surgeon. J Bone Joint Surg Am 90(Suppl 4):188–194PubMedCrossRef Dell R, Greene D, Schelkun SR, Williams K (2008) Osteoporosis disease management: the role of the orthopaedic surgeon. J Bone Joint Surg Am 90(Suppl 4):188–194PubMedCrossRef
18.
Zurück zum Zitat Gong HS, Oh WS, Chung MS, Oh JH, Lee YH, Baek GH et al (2009) Patients with wrist fractures are less likely to be evaluated and managed for osteoporosis. J Bone Joint Surg Am 91(10):2376–2380PubMedCrossRef Gong HS, Oh WS, Chung MS, Oh JH, Lee YH, Baek GH et al (2009) Patients with wrist fractures are less likely to be evaluated and managed for osteoporosis. J Bone Joint Surg Am 91(10):2376–2380PubMedCrossRef
19.
Zurück zum Zitat Hagino H, Sawaguchi T, Endo N, Ito Y, Nakano T, Watanabe Y et al (2012) The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int 90(1):14–21PubMedCrossRef Hagino H, Sawaguchi T, Endo N, Ito Y, Nakano T, Watanabe Y et al (2012) The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int 90(1):14–21PubMedCrossRef
20.
Zurück zum Zitat Bischoff HA, Stähelin HB, Monsch AU, Iversen MD, Weyh A, von Dechend M et al (2003) Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women. Age Ageing 32(3):315–320PubMedCrossRef Bischoff HA, Stähelin HB, Monsch AU, Iversen MD, Weyh A, von Dechend M et al (2003) Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women. Age Ageing 32(3):315–320PubMedCrossRef
21.
Zurück zum Zitat Thomas S, Mackintosh S, Halbert J (2010) Does the ‘Otago exercise programme’ reduce mortality and falls in older adults?: a systematic review and meta-analysis. Age Ageing 39(6):681–687PubMedCrossRef Thomas S, Mackintosh S, Halbert J (2010) Does the ‘Otago exercise programme’ reduce mortality and falls in older adults?: a systematic review and meta-analysis. Age Ageing 39(6):681–687PubMedCrossRef
22.
Zurück zum Zitat Hess LM, Raebel MA, Conner DA, Malone DC (2006) Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother 40(7–8):1280–1288PubMedCrossRef Hess LM, Raebel MA, Conner DA, Malone DC (2006) Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother 40(7–8):1280–1288PubMedCrossRef
23.
Zurück zum Zitat Bliuc D, Eisman JA, Center JR (2006) A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures. Osteoporos Int 17(9):1309–1317PubMedCrossRef Bliuc D, Eisman JA, Center JR (2006) A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures. Osteoporos Int 17(9):1309–1317PubMedCrossRef
24.
Zurück zum Zitat Jaglal SB, Hawker G, Bansod V, Salbach NM, Zwarenstein M, Carroll J et al (2009) A demonstration project of a multi-component educational intervention to improve integrated post-fracture osteoporosis care in five rural communities in Ontario, Canada. Osteoporos Int 20(2):265–274PubMedCrossRef Jaglal SB, Hawker G, Bansod V, Salbach NM, Zwarenstein M, Carroll J et al (2009) A demonstration project of a multi-component educational intervention to improve integrated post-fracture osteoporosis care in five rural communities in Ontario, Canada. Osteoporos Int 20(2):265–274PubMedCrossRef
25.
Zurück zum Zitat Ganda K, Puech M, Chen JS, Speerin R, Bleasel J, Center JR et al (2013) Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int 24(2):393–406PubMedCrossRef Ganda K, Puech M, Chen JS, Speerin R, Bleasel J, Center JR et al (2013) Models of care for the secondary prevention of osteoporotic fractures: a systematic review and meta-analysis. Osteoporos Int 24(2):393–406PubMedCrossRef
26.
Zurück zum Zitat Majumdar SR, Johnson JA, McAlister FA, Bellerose D, Russell AS, Hanley DA et al (2008) Multifaceted intervention to improve diagnosis and treatment of osteoporosis in patients with recent wrist fracture: a randomized controlled trial. CMAJ 178(5):569–575PubMedCrossRef Majumdar SR, Johnson JA, McAlister FA, Bellerose D, Russell AS, Hanley DA et al (2008) Multifaceted intervention to improve diagnosis and treatment of osteoporosis in patients with recent wrist fracture: a randomized controlled trial. CMAJ 178(5):569–575PubMedCrossRef
27.
Zurück zum Zitat Davis JC, Guy P, Ashe MC, Liu-Ambrose T, Khan K (2007) HipWatch: osteoporosis investigation and treatment after a hip fracture: a 6-month randomized controlled trial. J Gerontol A Biol Sci Med Sci 62(8):888–891PubMedCrossRef Davis JC, Guy P, Ashe MC, Liu-Ambrose T, Khan K (2007) HipWatch: osteoporosis investigation and treatment after a hip fracture: a 6-month randomized controlled trial. J Gerontol A Biol Sci Med Sci 62(8):888–891PubMedCrossRef
28.
Zurück zum Zitat Majumdar SR, Beaupre LA, Harley CH, Hanley DA, Lier DA, Juby AG et al (2007) Use of a case manager to improve osteoporosis treatment after hip fracture: results of a randomized controlled trial. Arch Intern Med 167(19):2110–2115PubMedCrossRef Majumdar SR, Beaupre LA, Harley CH, Hanley DA, Lier DA, Juby AG et al (2007) Use of a case manager to improve osteoporosis treatment after hip fracture: results of a randomized controlled trial. Arch Intern Med 167(19):2110–2115PubMedCrossRef
29.
Zurück zum Zitat Marsh D, Akesson K, Beaton DE, Bogoch ER, Boonen S, Brandi ML et al (2011) Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int 22(7):2051–2065PubMedCrossRef Marsh D, Akesson K, Beaton DE, Bogoch ER, Boonen S, Brandi ML et al (2011) Coordinator-based systems for secondary prevention in fragility fracture patients. Osteoporos Int 22(7):2051–2065PubMedCrossRef
30.
Zurück zum Zitat Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C et al (2007) Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 357(18):1799–1809PubMedCrossRef Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C et al (2007) Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 357(18):1799–1809PubMedCrossRef
31.
Zurück zum Zitat Schuit SCE, van der Klift M, Weel AEAM, de Laet CEDH, Burger H, Seeman E et al (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34(1):195–202PubMedCrossRef Schuit SCE, van der Klift M, Weel AEAM, de Laet CEDH, Burger H, Seeman E et al (2004) Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 34(1):195–202PubMedCrossRef
32.
Zurück zum Zitat Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA et al (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286(22):2815–2822PubMedCrossRef Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA et al (2001) Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 286(22):2815–2822PubMedCrossRef
33.
Zurück zum Zitat Queally JM, Kiernan C, Shaikh M, Rowan F, Bennett D (2013) Initiation of osteoporosis assessment in the fracture clinic results in improved osteoporosis management: a randomised controlled trial. Osteoporos Int 24(3):1089–1094PubMedCrossRef Queally JM, Kiernan C, Shaikh M, Rowan F, Bennett D (2013) Initiation of osteoporosis assessment in the fracture clinic results in improved osteoporosis management: a randomised controlled trial. Osteoporos Int 24(3):1089–1094PubMedCrossRef
34.
Zurück zum Zitat Blonk MC, Erdtsieck RJ, Wernekinck MGA, Schoon EJ (2007) The fracture and osteoporosis clinic: 1-year results and 3-month compliance. Bone 40(6):1643–1649PubMedCrossRef Blonk MC, Erdtsieck RJ, Wernekinck MGA, Schoon EJ (2007) The fracture and osteoporosis clinic: 1-year results and 3-month compliance. Bone 40(6):1643–1649PubMedCrossRef
35.
Zurück zum Zitat Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA et al (2006) Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc 81(8):1013–1022PubMedCrossRef Siris ES, Harris ST, Rosen CJ, Barr CE, Arvesen JN, Abbott TA et al (2006) Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc 81(8):1013–1022PubMedCrossRef
36.
Zurück zum Zitat Ojeda-Bruno S, Naranjo A, Francisco-Hernández F, Erausquin C, Rúa-Figueroa I, Quevedo JC et al (2011) Secondary prevention program for osteoporotic fractures and long-term adherence to bisphosphonates. Osteoporos Int 22(6):1821–1828PubMedCrossRef Ojeda-Bruno S, Naranjo A, Francisco-Hernández F, Erausquin C, Rúa-Figueroa I, Quevedo JC et al (2011) Secondary prevention program for osteoporotic fractures and long-term adherence to bisphosphonates. Osteoporos Int 22(6):1821–1828PubMedCrossRef
37.
Zurück zum Zitat Cheen MHH, Kong MC, Zhang RF, Tee FMH, Chandran M (2012) Adherence to osteoporosis medications amongst Singaporean patients. Osteoporos Int 23(3):1053–1060PubMedCrossRef Cheen MHH, Kong MC, Zhang RF, Tee FMH, Chandran M (2012) Adherence to osteoporosis medications amongst Singaporean patients. Osteoporos Int 23(3):1053–1060PubMedCrossRef
38.
Zurück zum Zitat Carter ND, Kannus P, Khan KM (2001) Exercise in the prevention of falls in older people: a systematic literature review examining the rationale and the evidence. Sports Med (Auckland NZ) 31(6):427–438CrossRef Carter ND, Kannus P, Khan KM (2001) Exercise in the prevention of falls in older people: a systematic literature review examining the rationale and the evidence. Sports Med (Auckland NZ) 31(6):427–438CrossRef
39.
Zurück zum Zitat Barnett A, Smith B, Lord SR, Williams M, Baumand A (2003) Community-based group exercise improves balance and reduces falls in at-risk older people: a randomised controlled trial. Age Ageing 32(4):407–414PubMedCrossRef Barnett A, Smith B, Lord SR, Williams M, Baumand A (2003) Community-based group exercise improves balance and reduces falls in at-risk older people: a randomised controlled trial. Age Ageing 32(4):407–414PubMedCrossRef
40.
Zurück zum Zitat Stineman MG, Strumpf N, Kurichi JE, Charles J, Grisso JA, Jayadevappa R et al (2011) Attempts to reach the oldest and frailest: recruitment, adherence, and retention of urban elderly persons to a falls reduction exercise program. Gerontologist 51(Suppl 1):S59–S72PubMedCrossRef Stineman MG, Strumpf N, Kurichi JE, Charles J, Grisso JA, Jayadevappa R et al (2011) Attempts to reach the oldest and frailest: recruitment, adherence, and retention of urban elderly persons to a falls reduction exercise program. Gerontologist 51(Suppl 1):S59–S72PubMedCrossRef
41.
Zurück zum Zitat Kuptniratsaikul V, Praditsuwan R, Assantachai P, Ploypetch T, Udompunturak S, Pooliam J et al (2011) Effectiveness of simple balancing training program in elderly patients with history of frequent falls. Clin Interv Aging 6:111–117PubMedCrossRef Kuptniratsaikul V, Praditsuwan R, Assantachai P, Ploypetch T, Udompunturak S, Pooliam J et al (2011) Effectiveness of simple balancing training program in elderly patients with history of frequent falls. Clin Interv Aging 6:111–117PubMedCrossRef
42.
Zurück zum Zitat Farmer KC (1999) Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 21(6):1074–90, discussion 1073PubMedCrossRef Farmer KC (1999) Methods for measuring and monitoring medication regimen adherence in clinical trials and clinical practice. Clin Ther 21(6):1074–90, discussion 1073PubMedCrossRef
43.
Zurück zum Zitat Steiner JF, Prochazka AV (1997) The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 50(1):105–116PubMedCrossRef Steiner JF, Prochazka AV (1997) The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol 50(1):105–116PubMedCrossRef
44.
Zurück zum Zitat Sikka R, Xia F, Aubert RE (2005) Estimating medication persistency using administrative claims data. Am J Manag Care 11(7):449–457PubMed Sikka R, Xia F, Aubert RE (2005) Estimating medication persistency using administrative claims data. Am J Manag Care 11(7):449–457PubMed
45.
Zurück zum Zitat Schwartz EN, Steinberg D (2005) Detection of vertebral fractures. Curr Osteoporos Rep 3(4):126–135PubMedCrossRef Schwartz EN, Steinberg D (2005) Detection of vertebral fractures. Curr Osteoporos Rep 3(4):126–135PubMedCrossRef
46.
Zurück zum Zitat Delmas PD, van de Langerijt L, Watts NB, Eastell R, Genant H, Grauer A et al (2005) Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res 20(4):557–563PubMedCrossRef Delmas PD, van de Langerijt L, Watts NB, Eastell R, Genant H, Grauer A et al (2005) Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res 20(4):557–563PubMedCrossRef
47.
Zurück zum Zitat Jager PL, Slart RH, Webber CL, Adachi JD, Papaioannou AL, Gulenchyn KY et al (2010) Combined vertebral fracture assessment and bone mineral density measurement: a patient-friendly new tool with an important impact on the Canadian Risk Fracture Classification. Can Assoc Radiol J 61(4):194–200PubMedCrossRef Jager PL, Slart RH, Webber CL, Adachi JD, Papaioannou AL, Gulenchyn KY et al (2010) Combined vertebral fracture assessment and bone mineral density measurement: a patient-friendly new tool with an important impact on the Canadian Risk Fracture Classification. Can Assoc Radiol J 61(4):194–200PubMedCrossRef
48.
Zurück zum Zitat Mitchell PJ (2013) Best practices in secondary fracture prevention: fracture liaison services. Curr Osteoporos Rep 11(1):52–60PubMedCrossRef Mitchell PJ (2013) Best practices in secondary fracture prevention: fracture liaison services. Curr Osteoporos Rep 11(1):52–60PubMedCrossRef
49.
Zurück zum Zitat Wee SL, Tan CGP, Ng HSH, Su S, Tai VUM, Flores JVPG et al (2008) Diabetes outcomes in specialist and general practitioner settings in Singapore: challenges of right-siting. Ann Acad Med Singapore 37(11):929–935PubMed Wee SL, Tan CGP, Ng HSH, Su S, Tai VUM, Flores JVPG et al (2008) Diabetes outcomes in specialist and general practitioner settings in Singapore: challenges of right-siting. Ann Acad Med Singapore 37(11):929–935PubMed
Metadaten
Titel
Secondary prevention of osteoporotic fractures—an “OPTIMAL” model of care from Singapore
verfasst von
M. Chandran
M. Z. W. Tan
M. Cheen
S. B. Tan
M. Leong
T. C. Lau
Publikationsdatum
01.11.2013
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 11/2013
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-013-2368-8

Weitere Artikel der Ausgabe 11/2013

Osteoporosis International 11/2013 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.