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European Journal of Nuclear Medicine and Molecular Imaging

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01.04.2004 | Original Article

Validation of 4D-MSPECT and QGS for quantification of left ventricular volumes and ejection fraction from gated ^99mTc-MIBI SPET: comparison with cardiac magnetic resonance imaging

verfasst von: Claudia S. A. Lipke, Harald P. Kühl, Bernd Nowak, Hans-Juergen Kaiser, Patrick Reinartz, Karl-Christian Koch, Udalrich Buell, Wolfgang M. Schaefer

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 4/2004

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Abstract

The main aim of this study was to validate the accuracy of 4D-MSPECT in the assessment of left ventricular (LV) end-diastolic/end-systolic volumes (EDV, ESV) and ejection fraction (LVEF) from gated technetium-99m methoxyisobutylisonitrile single-photon emission tomography (^99mTc-MIBI SPET), using cardiac magnetic resonance imaging (cMRI) as the reference method. By further comparing 4D-MSPECT and QGS with cMRI, the software-specific characteristics were analysed to elucidate clinical applicability. Fifty-four patients with suspected or proven coronary artery disease (CAD) were examined with gated ^99mTc-MIBI SPET (8 gates/cardiac cycle) about 60 min after tracer injection at rest. LV EDV, ESV and LVEF were calculated from gated ^99mTc-MIBI SPET using 4D-MSPECT and QGS. On the same day, cMRI (20 gates/cardiac cycle) was performed, with LV EDV, ESV and LVEF calculated using Simpson’s rule. Both algorithms worked with all data sets. Correlation between the results of gated ^99mTc-MIBI SPET and cMRI was high for EDV [R=0.89 (4D-MSPECT), R=0.92 (QGS)], ESV [R=0.96 (4D-MSPECT), R=0.96 (QGS)] and LVEF [R=0.89 (4D-MSPECT), R=0.90 (QGS)]. In contrast to ESV, EDV was significantly underestimated by 4D-MSPECT and QGS compared to cMRI [130±45 ml (4D-MSPECT), 122±41 ml (QGS), 139±36 ml (cMRI)]. For LVEF, 4D-MSPECT and cMRI revealed no significant differences, whereas QGS yielded significantly lower values than cMRI [57.5%±13.7% (4D-MSPECT), 52.2%±12.4% (QGS), 60.0%±15.8% (cMRI)]. In conclusion, agreement between gated ^99mTc-MIBI SPET and cMRI is good across a wide range of clinically relevant LV volume and LVEF values assessed by 4D-MSPECT and QGS. However, algorithm-varying underestimation of LVEF should be accounted for in the clinical context and limits interchangeable use of software.

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Titel: Validation of 4D-MSPECT and QGS for quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPET: comparison with cardiac magnetic resonance imaging
verfasst von: Claudia S. A. Lipke
Harald P. Kühl
Bernd Nowak
Hans-Juergen Kaiser
Patrick Reinartz
Karl-Christian Koch
Udalrich Buell
Wolfgang M. Schaefer
Publikationsdatum: 01.04.2004
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 4/2004
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-003-1411-y

Springer Medizin

Abstract

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