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European Journal of Nuclear Medicine and Molecular Imaging

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01.11.2004 | Original Article

Incremental predictive value of myocardial scintigraphy with¹²³I-BMIPP in patients with acute myocardial infarction treated with primary percutaneous coronary intervention

verfasst von: Mamoru Nanasato, Haruo Hirayama, Akitada Ando, Satoshi Isobe, Makoto Nonokawa, Yoshimi Kinoshita, Ichiro Nanbu, Mitsuhiro Yokota, Toyoaki Murohara

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2004

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Abstract

Purpose

It is unclear whether¹²³I-labelled β-methyl iodophenyl pentadecanoic acid (¹²³I-BMIPP) myocardial scintigraphy adds further predictive value for future cardiac events compared with the variables obtained during cardiac catheterisation in patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). We therefore investigated whether ¹²³I-BMIPP imaging in patients with AMI treated by primary PCI was useful in predicting future cardiac events.

Methods

One hundred and fifty-nine patients with AMI who were treated with primary PCI and underwent left ventriculography (LVG) on admission underwent ²⁰¹Tl and ¹²³I-BMIPP myocardial scintigraphy. Scintigrams were visually classified, and the total defect score (TDS) was calculated. Major adverse cardiac events (MACE) were defined as cardiac death including sudden death, congestive heart failure and recurrence of acute coronary syndrome. Patients were followed up for a mean of 34.5 months (12–63 months).

Results

Twenty-six patients had MACE. Kaplan-Meier analysis indicated that patients with the top 50% of ¹²³I-BMIPP TDSs had a significantly higher rate of MACE (P=0.007). Patients with mismatch between ²⁰¹Tl and ¹²³I-BMIPP images also had significantly more MACE (P=0.02). In the prediction of MACE, the global chi-square value was 5.2 (P=0.001) based on LVEF (<45%) and the number of diseased vessels (two or three). Adding ¹²³I-BMIPP TDS and the mismatch improved the global chi-square value (χ ²=7.2)

Conclusion

Myocardial scintigraphy using ²⁰¹Tl and ¹²³I-BMIPP predicts future cardiac events in patients with AMI treated with primary PCI, and provides additional predictive value compared with the variables obtained with cardiac catheterisation alone.

Zaret BL, Wacker FJT, Terrin ML, Forman SA, Williams DO, Knatterud GL, Braunwald E. Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: results of thrombolysis in myocardial infarction (TIMI) phase II study. J Am Coll Cardiol 1995;26:73–9CrossRefPubMed

Anderson JL, Platia EV, Hallstrom A, Henthorn RW, Buckingham TA, Carlson MD, Carson PE. Interaction of baseline characteristics with the hazard of encainide, flecainide, and moricizine therapy in patients with myocardial infarction: a possible explanation for increased mortality in the cardiac arrhythmia suppression trial (CAST). Circulation 1994;90:2843–52PubMed

Tamaki N, Kawamoto M, Takahashi N, Yonekura Y, Magata Y, Nohara R, Kambara H, Sasayama S, Hirata K, Ban T. Prognostic value of an increase in fluorine-18 deoxyglucose uptake in patients with myocardial infarction: comparison with stress thallium imaging. J Am Coll Cardiol 1993;15:1621–7

Huitink JM, Visser FC, Bax JJ, van Lingen A, Groenveld AB, Teule GJ, Visser CA. Predictive value of planar¹⁸F-fluorodeoxyglucose imaging for cardiac events in patients after acute myocardial infarction. Am J Cardiol 1998;81:1072–7CrossRefPubMed

Di Carli MF, Davidson M, Little R, Khanna S, Mody FV, Brunken RC, Czernin J, Rokhsar S, Stevenson LW, Laks H. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol 1994;73:527–33CrossRefPubMed

Tamaki N, Tadamura E, Kudoh T, Hattori N, Yonekura Y, Nohara R, Sasayama S, Ikebukuro K, Kato H, Konishi J. Prognostic value of iodine-123 labeled BMIPP fatty acid analogue imaging in patients with myocardial infarction. Eur J Nucl Med 1996;23:272–9PubMed

Nakata T, Kobayashi T, Tamaki N, Kobayashi T, Wakabayashi S, Shimoshige K, Oh-hori K, Hamabe K, Hirasawa T, Matsuki T, Shogase M, Furudate M, Shimanoto K. Prognostic value of impaired myocardial fatty acid uptake in patients with acute myocardial infarction. Nucl Med Commun 2000;21:897–906CrossRefPubMed

Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol 2002;9:240–5CrossRefPubMed

Wynne J, Green JH, Mann T, Levin D, Grossman W. Estimation of left ventricular volumes in man from biplane cineangiograms filmed in oblique projections. Am J Cardiol 1978;41:726–32CrossRefPubMed

10.

Gibson RS, Watson DD, Craddock GB, Crampton RS, Kaiser DL, Denny MJ, Beller GA. Prediction of cardiac events after uncomplicated myocardial infarction: a prospective study comparing predischarge exercise thallium-201 scintigraphy and coronary angiography. Circulation 1983;68:321–36PubMed

11.

Brown KA, Weiss RM, Clements JP, Wackers FJ. Usefulness of residual ischemic myocardium within prior infarct zone for identifying patients at high risk late after acute myocardial infarction. Am J Cardiol 1987;60:15–9CrossRefPubMed

12.

Kropp J, Eisenhur M, Ambrose KR, Knapp FF, Franke WG. Pharmacokinetics and metabolism of the methyl-branched fatty acid (BMIPP) in animals and humans. J Nucl Med 1999;40:1484–91PubMed

13.

Hosokawa R, Nohara R, Fujibayashi Y, Okuda K, Ogino M, Hata T, Fujita M, Tamaki N, Konishi J, Sasayama S. Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion: implications for clinical SPECT. J Nucl Med 1997;38:1857–63PubMed

14.

Fujiwara S, Takeishi Y, Atsumi H, Yamaki M, Takahashi N, Yamaoka M, Tojo T, Tomoike H. Prediction of functional recovery in acute myocardial infarction: comparison between sestamibi reverse redistribution and sestamibi/BMIPP mismatch. J Nucl Cardiol 1998;5:119–27CrossRefPubMed

15.

Marwick TH, Maclntyre WJ, Lafont A, Nemec JJ, Scalcedo EE. Metabolic response of hibernating and infarcted myocardium to revascularization. A follow-up study of regional perfusion, function and metabolism. Circulation 1992;85:1347–53PubMed

16.

Tanaka R, Nakamuta T. Time course evaluation of myocardial perfusion after reperfusion therapy by ^99mTc-tetrofosmin SPECT in patients with acute myocardial infarction. J Nucl Med 2001;42:1351–8PubMed

17.

Mochizuki T, Murase K, Higashino H, Miyagawa M, Sugawara Y, Kikuchi T, Ikezoe J. Ischemic “memory image” in acute myocardial infarction of ¹²³I-BMIPP after reperfusion therapy: a comparison with ^99mTc-pyrophosphate and ²⁰¹Tl dual-isotope SPECT. Ann Nucl Med 2002;16:563–8PubMed

18.

Nohara R, Okuda K, Ogino M, Hosokawa R, Tamaki N, Konishi J, Fujibayashi Y, Yonekura Y, Fujita M, Sasayama S. Evaluation of myocardial viability with iodine-123-BMIPP in a canine model. J Nucl Med 1996;37:1403–7PubMed

19.

Hashimoto A, Nakata T, Tsuchihashi K, Tanaka S, Fujimori K, Iimura O. Post ischemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. Am J Cardiol 1996;77:25–30CrossRefPubMed

20.

Hambye AS, Vervaet A, Dobbeleir A, Dendale P, Franken P. Prediction of functional outcome by quantification of sestamibi and BMIPP after acute myocardial infarction. Eur J Nucl Med 2000;27:1494–500CrossRefPubMed

21.

Nakajima K, Shimizu K, Taki J, Uetani Y, Konishi S, Tonami N, Hisada K. Utility of iodine-123-BMIPP in the diagnosis and follow-up of vasospastic angina. J Nucl Med 1995;36:1934–40PubMed

22.

Takeishi Y, Sukekawa H, Saito H, Nisihmura S, Shibu T, Sasaki Y, Tomoike H. Clinical significance of decreased myocardial uptake of¹²³I-BMIPP in patients with stable angina pectoris. Nucl Med Commun 1995;16:1002–8PubMed

23.

Kudoh E, Tadamura E, Tamaki N, Hattori N, Inubushi M, Kubo S, Magata Y, Nishimura K, Matsuda K, Konishi J. Iodinated free fatty acid and ²⁰¹Tl uptake in chronically hypoperfused myocardium: histologic correlation study. J Nucl Med 2000;41:293–6PubMed

24.

Franken PR, Geeter FD, Dendale P, Demoor D, Block P, Bossuyt A. Abnormal fatty acid uptake in subacute myocardial infarction after coronary thrombosis: correlation with wall motion and inotropic reserve. J Nucl Med 1994;35:1758–65PubMed

25.

Dendale P, Franken PR, van der Wall EE, de Roos A. Wall thickening at rest and contractile reserve early after myocardial infarction: correlation with myocardial perfusion and metabolism. Coron Artery Dis 1997;8;259–64

26.

Tamaki N, Tadamura E, Kawamoto M, Magata Y, Yonekura Y, Fujibayashi Y, Nohara R, Sasayama S, Konishi J. Decreased uptake of iodinated branched fatty acid analog indicates metabolic alterations in ischemic myocardium. J Nucl Med 1995;36:1974–80PubMed

27.

Tamaki N, Kawamoto M, Tadamura E, Magata Y, Yonekura Y, Nohara R, Sasayama S, Nishimura K, Ban T, Konishi J. Prediction of reversible ischemia after revascularization. Perfusion and metabolic studies with positron emission tomography. Circulation 1995;91:1697–705PubMed

28.

Schöder H, Campisi R, Ohtake T, Hoh CK, Moon DH, Czernin J, Schelbert HR. Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction. J Am Coll Cardiol 1999;33:1328–37CrossRefPubMed

29.

Taniguchi J, Noma A, Irisawa H. Modification of cardiac action potential by intracellular injection of adenosine triphosphate and related substances in guinea pig single ventricular cells. Circ Res 1983;53:131–9PubMed

30.

Fujibayashi Y, Yonekura Y, Takemura Y, Wada K, Matsumoto K, Tamaki N, Yamamoto K, Konishi J, Yokoyama A. Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid (BMIPP), in relation to ATP concentration. J Nucl Med 1990;31:1818–22PubMed

31.

Grines CL, Cox DA, Stone GW, Garcia E, Mattos LA, Giambartolomei A, Brodie BR, Madonna O, Eijgelshoven M, Lansky AJ, O’Neill WW, Morice MC. Coronary angioplasty with or without stent implantation for acute myocardial infarction. N Engl J Med 1999;341:1949–56CrossRefPubMed

32.

Montalescot G, Barragan P, Wittenberg O, Ecollan P, Elhadad S, Villain P, Boulenc JM, Morice MC, Maillard L, Pansiri M, Choussat R, Pinton P. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med 2001;344:1895–903CrossRefPubMed

33.

Petronio AS, Rovai D, Musumeci G, Baglini R, Nardi C, Limbruno U, Palagi C, Volterrani D, Mariani M. Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute myocardial infarction treated by primary coronary angioplasty. Eur Heart J 2003;24:67–76CrossRefPubMed

34.

Ito H, Taniyama Y, Iwakura K, Nishikawa N, Masuyama T, Kuzuya T, Hori M, Higashino Y, Fujii K, Minamino T. Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction. J Am Coll Cardiol 1999;33:654–60CrossRefPubMed

35.

Fukuzawa S, Ozawa S, Inagaki M, Shimada K, Sugioka J, Tateno K, Ueda M. Nicorandil affords cardiac protection in patients with acute myocardial infarction treated with primary PTCA: assessment with thallium-201/iodine-123 BMIPP dual SPECT. J Nucl Cardiol 2000;7:447–53CrossRefPubMed

36.

Lenderink T, Simoons ML, Van Es G-A, Van de Werf F, Verstraete M, Arnold AE. Benefit of thrombolytic therapy is sustained throughout five years and is related to TIMI perfusion grade 3 but not grade 2 flow at discharge. Circulation 1995;92:1110–6PubMed

37.

Late Study Group. Late assessment of thrombolytic efficacy (LATE) study with alteplase 6–24 hours after onset of acute myocardial infarction. Lancet 1993;342:759–66CrossRefPubMed

38.

Mahmarian JJ, Mahmarian AC, Marks GF, Pratt CM, Verani MS. Role of adenosine thallium-201 tomography for defining long-term risk in patients after acute myocardial infarction. J Am Coll Cardiol 1995;25:1333–40CrossRefPubMed

Titel: Incremental predictive value of myocardial scintigraphy with 123I-BMIPP in patients with acute myocardial infarction treated with primary percutaneous coronary intervention
verfasst von: Mamoru Nanasato
Haruo Hirayama
Akitada Ando
Satoshi Isobe
Makoto Nonokawa
Yoshimi Kinoshita
Ichiro Nanbu
Mitsuhiro Yokota
Toyoaki Murohara
Publikationsdatum: 01.11.2004
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2004
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1556-3

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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